The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]
, 2015 This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara +7 more
core +1 more source
PLoS Pathogens, 2022 As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the other hand, cells evolved multiple mechanisms of detecting and interfering with viral replication.
Seyedehmahsa Moghimi +7 more
doaj +1 more source
Low-Level HIV-I Replication and the Dynamics of the Resting CD4(+) T Cell Reservoir for HIV-I in the Setting of HAART [PDF]
, 2008 In the setting of highly active antiretroviral therapy (HAART), plasma levels of human immunodeficiency type-I (HIV-I) rapidly decay to below the limit of detection of standard clinical assays.
Sedaghat, Ahmad R. +2 more
core +1 more source
Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection [PDF]
, 2002 Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single ...
Clotet, B +4 more
core +2 more sources
Longitudinal sequencing of HIV-1 infected patients with low-level viremia for years while on ART shows no indications for genetic evolution of the virus [PDF]
, 2017 HIV-infected patients on antiretroviral therapy (ART) may present low-level viremia (LLV) above the detection level of current viral load assays.
Dauwe, Kenny +7 more
core +1 more source
Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression [PDF]
, 2015 Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic ...
Alison J. Sinclair +77 more
core +1 more source
, 1987 Viral replication is the central focus of much experimental virology and is a significant part of molecular biology. Studies with bacteriophages in their prokaryotic host cells in the 1940s and 1950s provided the first insights into the complexities of viral replication. With the development of mammalian cell culture procedures, the techniques used for
FENNER, FRANK +5 more
openaire +2 more sources
The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid [PDF]
, 2013 Respiratory Syncytial Virus (RSV) is an important human pathogen. Its nucleocapsid (NC), which comprises the negative sense RNA viral genome coated by the viral nucleoprotein N, is a critical assembly that serves as template for both mRNA synthesis and ...
Bhella +10 more
core +2 more sources
Viperin Poisons Viral Replication [PDF]
Cell Host & Microbe, 2018 Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering insights into drug design.
Julian A. Hiscox +3 more
openaire +3 more sources
Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments [PDF]
, 2009 Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV ...
Ahmed +25 more
core +2 more sources