Results 51 to 60 of about 2,261,873 (405)

Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection [PDF]

, 2002
Although antiviral agents which block human immunodeficiency virus (HIV) replication can result in long-term suppression of viral loads to undetectable levels in plasma, long-term therapy fails to eradicate virus, which generally rebounds after a single ...
Clotet, B, Frost, SDW, Leigh Brown, AJ, Martinez-Picado, J, Ruiz, L   +4 more
core   +2 more sources

Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression [PDF]

, 2015
Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic ...
Alison J. Sinclair, Anja Godfrey, Bailey, Bark-Jones, Beatty, Ben-Bassat, Bergbauer, Bhende, Bhende, Broderick, Carey, Chang, Chi, Farnham, Feederle, Feng, Flemington, Flower, Gentleman, Gordon Peters, Grabherr, Gupta, Gustems, Halder, Harshil Patel, Heather, Hollyoake, Hsu, Huang da, Huang da, Ijiel B. Naranjo Perez-Fernandez, Inman, Israel, Jiang, Jianmin Zuo, Kalla, Kalla, Kay Osborn, Kenney, Kenney, Klug, Krig, Kuppers, Li, Lieberman, Lieberman, Lieberman, Longnecker, Ma, Machanick, Martin Rowe, McClellan, Miller, Molyneux, Nicolae Balan, Pruitt, Rajaei Al-Mohammad, Ramasubramanyan, Ramasubramanyan, Richard G. Jenner, Rickinson, Rowe, Rowe, Scacheri, Shannon-Lowe, Sharada Ramasubramanyan, Takada, Thorvaldsdottir, Tsai, Tsang, Vetsika, Whyte, Yang, Young, Young, Yuan, Zuo, Zuo   +77 more
core   +1 more source

N6-methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication

Science, 2019
RNA modification meets immune metabolism N6-methyladenosine (m6A) RNA modification regulates various cellular functions. Liu et al. found that host cells impair RNA m6A demethylase activity after viral infection, leading to increased m6A and reduced ...
Yang Liu, Yuling You, Zhike Lu, Jiang Yang, Panpan Li, Lun Liu, Henan Xu, Ya-Zhou Niu, Xuetao Cao   +8 more
semanticscholar   +1 more source

The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid [PDF]

, 2013
Respiratory Syncytial Virus (RSV) is an important human pathogen. Its nucleocapsid (NC), which comprises the negative sense RNA viral genome coated by the viral nucleoprotein N, is a critical assembly that serves as template for both mRNA synthesis and ...
Bhella, Colin Loney, David Bhella, Edward Conner, Egelman, Fix, Félix A. Rey, Jean-François Eléouët, Marie Galloux, Saskia E. Bakker, Stéphane Duquerroy   +10 more
core   +3 more sources

Elements in the 5′ Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging

Viruses
During retrovirus assembly, Gag packages unspliced viral RNA as the virion genome. Genome packaging is usually specific with occasional exceptions of cross-packaging RNA from distantly related retroviruses.
Zetao Cheng, Olga A. Nikolaitchik, Alice Duchon, Jonathan M. O. Rawson, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

Cellular IP₆ Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP₆ Are Attenuated for Infection and Replication [PDF]

, 2019
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Böcking, Till, Faysal, K. M.Rifat, Fletcher, Adam J., Freed, Eric O., James, Leo C., Kleinpeter, Alex, Mallery, Donna L., Novikova, Mariia, Saiardi, Adolfo, Vaysburd, Marina, Wilson, Miranda S.C.   +10 more
core   +3 more sources

Epitranscriptomic regulation of viral replication

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2017
RNA plays central roles in biology and novel functions and regulation mechanisms are constantly emerging. To accomplish some of their functions within the cell, RNA molecules undergo hundreds of chemical modifications from which N6-methyladenosine (m6A), inosine (I), pseudouridine (ψ) and 5-methylcytosine (5mC) have been described in eukaryotic mRNA ...
Pereira-Montecinos, Camila, Valiente-Echeverría, Fernando, Soto Rifo, Ricardo   +2 more
openaire   +3 more sources

Noise cancellation: viral fine tuning of the cellular environment for its own genome replication. [PDF]

PLoS Pathogens, 2010
Productive replication of DNA viruses elicits host cell DNA damage responses, which cause both beneficial and detrimental effects on viral replication.
Yoshitaka Sato, Tatsuya Tsurumi
doaj   +1 more source

Identification of Epstein-Barr virus replication proteins in Burkitt’s lymphoma cells [PDF]

, 2015
The working model to describe the mechanisms used to replicate the cancer-associated virus Epstein-Barr virus (EBV) is partly derived from comparisons with other members of the Herpes virus family.
Almohammad, Rajei, Heesom, Kate, Matthews, David, Ramasubramanyan, Sharada, Rowe, Martin, Sinclair, Alison J, Sweet, Steve M M, Traylen, Chris, Zuo, Jianmin   +8 more
core   +2 more sources

Dengue virus-induced ER stress is required for autophagy activation, viral replication, and pathogenesis both in vitro and in vivo

Scientific Reports, 2018
Dengue virus (DENV) utilizes the endoplasmic reticulum (ER) for replication and assembling. Accumulation of unfolded proteins in the ER lumen leads to ER stress and unfolded protein response (UPR).
Ying-Ray Lee, Szu-Han Kuo, Ching-Yen Lin, Po-Jung Fu, Yee‐Shin Lin, T. Yeh, H-S Liu   +6 more
semanticscholar   +1 more source