A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]
, 2017 Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel +1 more
core +2 more sources
Sequence Instability in the Proviral Long Terminal Repeat and gag Regions from Peripheral Blood and Tissue-Derived Leukocytes of FIV-Infected Cats during the Late Asymptomatic Phase. [PDF]
, 2016 Feline immunodeficiency virus (FIV) infection results in viral persistence, a prolonged asymptomatic phase, and progressive immunopathology. During the asymptomatic phase, a cohort of experimentally FIV-infected cats exhibits features of viral latency in
Eckstrand, Christina D +2 more
core +3 more sources
, 1987 Viral replication is the central focus of much experimental virology and is a significant part of molecular biology. Studies with bacteriophages in their prokaryotic host cells in the 1940s and 1950s provided the first insights into the complexities of viral replication. With the development of mammalian cell culture procedures, the techniques used for
FENNER, FRANK +5 more
openaire +2 more sources
Science, 2019 RNA modification meets immune metabolism N6-methyladenosine (m6A) RNA modification regulates various cellular functions. Liu et al. found that host cells impair RNA m6A demethylase activity after viral infection, leading to increased m6A and reduced ...
Yang Liu +8 more
semanticscholar +1 more source
Antiviral and antioxidant activity of a hydroalcoholic extract from Humulus lupulus L. [PDF]
, 2018 A hydroalcoholic extract from female inflorescences of Humulus lupulus L. (HOP extract) was evaluated for its anti-influenza activity. The ability of the extract to interfere with different phases of viral replication was assessed, as well as its effect ...
Carissimi, Stefania +12 more
core +1 more source
Viperin Poisons Viral Replication [PDF]
Cell Host & Microbe, 2018 Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering insights into drug design.
Julian A. Hiscox +3 more
openaire +3 more sources
HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection. [PDF]
, 2017 Antiviral innate host defenses against acute viral infections include suppression of host protein synthesis to restrict viral protein production.
Clarissa Santos Rocha +9 more
core +2 more sources
Dynamic models of viral replication and latency [PDF]
Current Opinion in HIV and AIDS, 2015 Current Opinion in HIV and AIDS, 10 (2)
Mohammadi Pejman +2 more
openaire +5 more sources
Neural Replicator Analysis of the genus Flavivirus [PDF]
arXiv, 2023 The results of applying neural replicator analysis (NRA) to the genomes of viruses belonging to the genus Flavivirus are presented. It is shown that the viral genomes considered in this study can be placed in five different cells of the viral genome table.
arxiv
The evolution of virulence in RNA viruses under a competition-colonization trade-off [PDF]
Bull Math Biol, 2010, 2010 RNA viruses exist in large intra-host populations which display great genotypic and phenotypic diversity. We analyze a model of viral competition between two different viral strains infecting a constantly replenished cell pool, in which we assume a trade-off between the virus' colonization skills (cell killing ability or virulence) and its local ...
arxiv +1 more source