Results 1 to 10 of about 7,461 (205)

Stroke genetics: prospects for personalized medicine. [PDF]

, 2012
Epidemiologic evidence supports a genetic predisposition to stroke. Recent advances, primarily using the genome-wide association study approach, are transforming what we know about the genetics of multifactorial stroke, and are identifying novel stroke ...
A Gschwendtner, A Hassan, A Helgadottir, A Helgadottir, A Joutel, A Viswanathan, AB Singleton, AJ Bowes, AV Shirodkar, B Rohrer, C Bellenguez, CAPRIE Steering Committee, CS Ku, D Sibbing, DF Gudbjartsson, DJ Klionsky, DK Wysowski, DL Bhatt, DR Holmes Jr, DS Budnitz, E Flossmann, G Paré, HC Diener, HS Markus, HS Markus, Hugh S Markus, J Hardy, JA Johnson, JB Olesen, JF Meschia, JL Mega, JN Hirschhorn, JT O'Brien, L Wang, M Dichgans, M Kubo, M Serizawa, MA Ikram, MV Holmes, P Jerrard-Dunne, P Kraft, P Polychronopoulos, PC Ng, RL Sacco, RS Epstein, S Bevan, S Gretarsdottir, S Gretarsdottir, S Lanfranconi, S Olsson, S Seshadri, S Seshadri, SE Nissen, The International Warfarin Pharmacogenetics Consortium, VG Manolopoulos, VL Roger   +55 more
core   +2 more sources

One Rare Warfarin Resistance Case and Possible Mechanism Exploration

Pharmacogenomics and Personalized Medicine, 2023
Li Zhao,1 Zhenguo Zhai,2 Pengmei Li1 1Pharmacy Department, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, People’s Republic of ...
Zhao L, Zhai Z, Li P
doaj  

Field trials to assess resistance to warfarin and difenacoum of house mice in relation to the occurrence of variants in the vkorc1-gene before and after the treatments

Julius-Kühn-Archiv, 2011
House mice (Mus musculus domesticus) vary considerably in their susceptibility to anticoagulants, and several non-synonymous sequence variants in the coding region of the vitamin K epoxide reductase subcomponent 1 gene (vkorc1) were found in Germany ...
Endepols, S., Klemann, N., Song, Y., Kohn, M. H.   +3 more
doaj   +1 more source

Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study

Clinics, 2019
OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with ...
Merih Ozgen, Didem Turgut Cosan, Fulya Doganer, Ahu Soyocak, Onur Armagan, Selen Kuzgun, Ayse Merve Aydogan, Hasan Veysi Gunes, Irfan Degirmenci, Fezan Mutlu   +9 more
doaj   +1 more source

A Simulation Platform to Examine Heterogeneity Influence on Treatment [PDF]

, 2013
Although a protocol aims to guide treatment management and optimize overall outcomes, the benefits and harms for each individual vary due to heterogeneity. Some protocols integrate clinical and genetic variation to provide treatment recommendation; it is
Chi, Chih-Lin, Content, Charles F., Crawford, Matthew A., Fusaro, Vincent Alfred, Patil, Prasad, Tonellato, Peter J.   +5 more
core  

Warfarin anticoagulant therapy: a Southern Italy pharmacogenetics-based dosing model.

PLoS ONE, 2013
Background and aimWarfarin is the most frequently prescribed anticoagulant worldwide. However, warfarin therapy is associated with a high risk of bleeding and thromboembolic events because of a large interindividual dose-response variability.
Cristina Mazzaccara, Valeria Conti, Rosario Liguori, Vittorio Simeon, Mario Toriello, Angelo Severini, Corrado Perricone, Alfonso Meccariello, Pasquale Meccariello, Dino Franco Vitale, Amelia Filippelli, Lucia Sacchetti   +11 more
doaj   +1 more source

Gender differences in the association of vitamin k epoxide reductase complex subunit 1 gene promoter polymorphism with ischemic atherothrombotic stroke [PDF]

, 2016
Метою представленої роботи було встановлення можливого зв’язку поліморфізму G-1639A промотора гена VKORC1 з ризиком розвитку ішемічного атеротромботичного інсульту (ІАТІ) в осіб різної статі. Матеріали і методи.
Ataman, Oleksandr Vasylovych, Dubovyk, Yevhen Ivanovych, Harbuzova, Yelizaveta Antonivna, Атаман, Александр Васильевич, Атаман, Олександр Васильович, Гарбузова, Елизавета Антоновна, Гарбузова, Єлізавета Антонівна, Дубовик, Евгений Иванович, Дубовик, Євген Іванович   +8 more
core  

Real warfarin resistance or medication noncompliance? [PDF]

, 2010
The word noncompliance comes too many times in the physicians' notes, particularly when the out-come is not in sync with the standard of care these days.
Devkota, Bishnu, Sharma, Ajay
core  

Pharmacogenetics of warfarin - is testing clinically indicated? [PDF]

, 2009
Pharmacogenetics is genetic testing to optimise prescribing for individual patients. Warfarin is a potential candidate for pharmacogenetic testing as it is commonly used, has a narrow therapeutic window and its mechanism of action and elimination ...
Martin, JH
core   +1 more source

АНАЛИЗ ВЗАИМОСВЯЗИ МЕЖДУ НОСИТЕЛЬСТВОМ АЛЛЕЛЕЙ ПОЛИМОРФИЗМА CYP2C9*2 ГЕНА CYP2C9 И G(-1639)A ПОЛИМОРФНОГО МАРКЕРА ГЕНА VKORC1 С РАЗВИТИЕМ ЭПИЗОДОВ ЧРЕЗМЕРНОЙ ГИПОКОАГУЛЯЦИИ НА ФОНЕ АНТИКОАГУЛЯНТНОЙ ТЕРАПИИ ВАРФАРИНОМ

Евразийский Кардиологический Журнал, 2019
Анализ взаимосвязи между носительством определенных аллелей полиморфизмов CYP2C9*2 гена CYP2C9 и полиморфного маркера VKORC1 G(-1639)A гена VKORC1 с развитием ЧГ у пациентов узбекской национальности на фоне терапии варфарином (Вф).

doaj