Analysis of
BMC Genetics, 2010 Background Certain mutations in the vitamin K epoxide reductase subcomponent 1 gene (vkorc1) mediate rodent resistance to warfarin and other anticoagulants. Testing for resistance often involves analysis of the vkorc1.
Borchert Jeff N +4 more
doaj +3 more sources
Association Between VKORC1 Gene Polymorphisms and Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis [PDF]
MedicinaBackground and Objectives: The vitamin K epoxide reductase complex subunit 1 (VKORC1) plays a central role in the vitamin K cycle, which is essential for γ-carboxylation of multiple bone-related proteins.
Ştefan Cristian Vesa +9 more
doaj +2 more sources
The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients [PDF]
Frontiers in PharmacologyBackgroundLimited data are available on factors that affect warfarin dose requirement in Saudi patients. Saudis are among the underrepresented ethnic groups in warfarin pharmacogenetics research.
Salha Jokhab +5 more
doaj +2 more sources
Novel associations of VKORC1 variants with higher acenocoumarol requirements. [PDF]
PLoS ONE, 2013 Algorithms combining both clinical and genetic data have been developed to improve oral anticoagulant therapy. Three polymorphisms in two genes, VKORC1 and CYP2C9, are the main coumarin dose determinants and no additional polymorphisms of any relevant ...
Ana Isabel Anton +7 more
doaj +4 more sources
Predictor Role of VKORC1 rs9923231, CYP4F2 rs2108622, and GGCX rs11676382 Polymorphisms of 5 Years Mortality of Patients with Acute Ischemic Stroke [PDF]
MedicinaBackground and Objectives: The aim of this study was to evaluate the potential predictive value of VKORC1, CYP4F2, and GGCX polymorphisms, as well as other clinical and demographic factors, for 5-year mortality in patients with acute ischemic stroke (AIS)
Silvina Iluţ +11 more
doaj +2 more sources
Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction [PDF]
Thrombosis Journal, 2008 Background Warfarin treatment has a narrow therapeutic range, requiring meticulous monitoring and dosage titration. Individual dosage requirement has recently partly been explained by genetic variation of the warfarin metabolizing enzyme CYP2C9 and the ...
Seljeflot Ingebjørg +9 more
doaj +3 more sources
A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats☆ [PDF]
Artery Research, 2008 Background: The inhibition of the vitamin K cycle by warfarin promotes arterial calcification in the rat. Conceivably, genetically determined vitamin K deficiency owing to a mutant epoxide reductase subcomponent 1 (Vkorc1) gene, a key component of the ...
Michael H. Kohn +2 more
doaj +3 more sources
Improving Genotype Imputation in High-Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches. [PDF]
Clin Pharmacol TherMultiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Asiimwe IG +6 more
europepmc +2 more sources
The VKORC1 and CYP2C9 gene variants as pharmacogenetic factors in acenocoumarol therapy in Serbian patients - consideration of hypersensitivity and resistance [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2022 Introduction/Objective. Coumarin therapy represents one of the best models for applying pharmacogenetics. The contribution of factors influencing coumarin therapy can vary significantly between ethnic groups, which justifies conducting population ...
Rakićević Ljiljana +3 more
doaj +1 more source
VKORC1 Pharmacogenomics Summary [PDF]
Pharmacogenetics and Genomics, 2010 The VKORC1 gene encodes the VKORC1 (vitamin K epoxide reductase) protein, which is a key enzyme in the vitamin K cycle [1,2]. VKORC1 is a 163 amino acid integral membrane protein associated with the endoplasmic reticulum and VKORC1 mRNA is broadly expressed in many different tissues [3].
Ryan P, Owen +4 more
openaire +2 more sources