Results 21 to 30 of about 7,461 (205)

VKORC1: molecular target of coumarins [PDF]

Journal of Thrombosis and Haemostasis, 2007
The genetic diagnosis of a single family with combined vitamin K-dependent clotting factor deficiency (VKCFD2, OMIM #607473) finally led to the identification and molecular characterization of vitamin K epoxide reductase (VKORC1). VKORC1 is the key enzyme of the vitamin K cycle and the molecular target of coumarins, which represent the most commonly ...
J, Oldenburg, M, Watzka, S, Rost, C R, Müller   +3 more
openaire   +2 more sources

Variation in VKORC1 Is Associated with Vascular Dementia [PDF]

Journal of Alzheimer’s Disease, 2020
Background: The genetic variant rs9923231 ( VKORC1) is associated with differences in the coagulation of blood and consequentially with sensitivity to the drug warfarin. Variation in VKORC1 has been linked in a gene-based test to dementia/Alzheimer’s disease in the parents of participants,
Jure Mur, Daniel L. McCartney, Daniel I. Chasman, Peter M. Visscher, Graciela Muniz-Terrera, Simon R. Cox, Tom C. Russ, Riccardo E. Marioni   +7 more
openaire   +4 more sources

Lack of Association of Clinical Factors (SAMe-TTR) with / Genotype and Anticoagulation Control Quality [PDF]

Journal of Stroke, 2015
Background and PurposeAdvantages of new oral anticoagulations may be greater in atrial fibrillation (AF) patients of poor anticoagulation control with warfarin.
Yun Kyung Park, Mi ji Lee, Jae Ha Kim, Suk Jae Kim, June Soo Kim, Soo-Youn Lee, Oh Young Bang   +6 more
doaj   +1 more source

Pharmacogenomic testing and its future in community pharmacy [PDF]

, 2020
Although it is common to see pharmacogenomic testing used North America and Australia, it is not yet part of practice in the UK. With the promise of genomic screening becoming part of the NHS, pharmacists must equip themselves with a knowledge of how the
Wright, David, Youssef, Essra
core   +1 more source

Economic evaluations of pharmacogenetic and pharmacogenomic screening tests : a systematic review : second update of the literature [PDF]

, 2016
Objective : Due to extended application of pharmacogenetic and pharmacogenomic screening (PGx) tests it is important to assess whether they provide good value for money. This review provides an update of the literature. Methods : A literature search was
Annemans, Lieven, Berm, Elizabeth JJ, Boersma, Cornelis, de Looff, Margot, Postma, Maarten J, van Boven, Job FM, Vegter, Stefan, Wilffert, Bob   +7 more
core   +9 more sources

Sodium dehydroacetate-induced disorder of coagulation function in broiler chickens and the protective effect afforded by vitamin K

Poultry Science, 2023
: Sodium dehydroacetate (S-DHA) is used widely as a preservative in several products, including poultry feed. The anticoagulation effect of 200 mg/kg S-DHA in rats has been reported to accompany a reduction in hepatic expression of vitamin K epoxide ...
Jinge Xu, Fuxing Hao, Cunkai Wang, Zeting Zhao, Meng Zhang, Xin Chen, Yumei Zhang   +6 more
doaj   +1 more source

GGCX and VKORC1 inhibit osteocalcin endocrine functions [PDF]

Journal of Cell Biology, 2015
Osteocalcin (OCN) is an osteoblast-derived hormone favoring glucose homeostasis, energy expenditure, male fertility, brain development, and cognition. Before being secreted by osteoblasts in the bone extracellular matrix, OCN is γ-carboxylated by the γ-carboxylase (GGCX) on three glutamic acid residues, a cellular process requiring reduction of vitamin
Ferron, Mathieu, Lacombe, Julie, Germain, Amélie, Oury, Franck, Karsenty, Gérard   +4 more
openaire   +2 more sources

Structural Modeling Insights into Human VKORC1 Phenotypes [PDF]

Nutrients, 2015
Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) catalyses the reduction of vitamin K and its 2,3-epoxide essential to sustain γ-carboxylation of vitamin K-dependent proteins. Two different phenotypes are associated with mutations in human VKORC1.
Czogalla, Katrin J., Watzka, Matthias, Oldenburg, Johannes   +2 more
openaire   +2 more sources

VKORC1 single nucleotide polymorphisms in rodents in Spain

Chemosphere, 2022
Rodents are considered one of the animal pests with the greatest impact on agricultural production and public health. Anticoagulant rodenticides (ARs), used as one of the most effective ways to control rodent populations worldwide, inhibit the vitamin K 2,3-epoxide reductase (VKORC1) enzyme involved in blood coagulation.
Azucena Bermejo-Nogales, José A. Rodríguez Martín, Julio Coll, José M. Navas   +3 more
openaire   +3 more sources

Genetic Warfarin-Resistance Resulting in Surgery to Change a Prosthetic Valve

European Journal of Case Reports in Internal Medicine, 2020
Warfarin is a readily available anticoagulant used worldwide in a variety of clinical scenarios. Patients who need more than 15 mg/day are considered to be warfarin resistant.
Jahanzeb Malik, Uzma Ishaq, Nismat Javed, Mirza Adnan Baig, Muhammad Javaid   +4 more
doaj   +1 more source