Results 31 to 40 of about 7,461 (205)

Vitamin K suppression of ferroptosis in neuronal model systems [PDF]

Alzheimers Dement
Abstract Background Ferroptosis (iron‐mediated phospholipid peroxidation) has been implicated in neuronal loss associated with Alzheimer's disease (AD). Glutathione Peroxidase‐4 (GPX4) mitigates ferroptosis in healthy neurons, but the activity of this pathway declines with age.
Narvaez C, Welsh J.
europepmc   +2 more sources

Pharmacogenomic Calling From Whole-Exome Sequencing in the Taiwanese Population-A Real-World Experience. [PDF]

Mol Genet Genomic Med
This study evaluated pharmacogenomic (PGx) calling from whole‐exome sequencing (WES) in 3562 Taiwanese individuals. Fourteen pharmacogenes were reliably identified, with each person carrying an average of ~2.4 actionable phenotypes. The high actionable frequencies of G6PD deficiency and HLA‐B*58:01 highlight ethnic differences and support WES as a ...
Lin HH, Tsai MM, Chen HA, Hsu RH, Lin YS, Lin YL, Hsu C, Chien YH, Hwu WL, Lee NC.   +9 more
europepmc   +2 more sources

VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites

Blood Advances, 2018
: Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo, VKORC1 reduces vitamin K to sustain γ-carboxylation of vitamin K-dependent proteins,
Katrin J. Czogalla, Kerstin Liphardt, Klara Höning, Veit Hornung, Arijit Biswas, Matthias Watzka, Johannes Oldenburg   +6 more
doaj   +1 more source

Large-scale structure of brown rat (Rattus norvegicus) populations in England: effects on rodenticide resistance [PDF]

, 2015
The brown rat (Rattus norvegicus) is a relatively recent (
Adams, Sally, Haniza, Mohd Z.H., Jones, Eleanor P., Lambert, Mark S., MacNicoll, Alan, Mallon, Eamonn B., Smith, Robert H.   +6 more
core   +2 more sources

Effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness during the stabilization phase of therapy

Saudi Pharmaceutical Journal, 2019
The main objective of this study is to assess the effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness in a Jordanian population during the stabilization phase of treatment.
Laith N. AL-Eitan, Ayah Y. Almasri, Rame H. Khasawneh   +2 more
doaj   +1 more source

The efficacy of low-dose warfarin initiation (3 mg versus 5 mg) in newly diagnosed venous thromboembolism patients among a population with a high prevalence of warfarin-sensitive haplotype of the VKORC1 gene: a randomized controlled trial

Hematology, 2022
Objectives The fact that a lower warfarin maintenance dose is required by Asian populations is well-known. Currently, the American College of Chest Physicians recommends commencing warfarin at a dose between 5 and 10 mg for venous thromboembolism (VTE ...
Bundarika Suwanawiboon, Wannaphorn Rotchanapanya, Komkrit Mahaprom, Wanna Thongnoppakhun, Yupaporn Lalerd, Chanin Limwongse, Nuttawut Sermsathanasawadi, Weerapat Owattanapanich   +7 more
doaj   +1 more source

بررسی فارماکوژنتیک وارفارین با ژنوتیپ پلی‌مورفیسم ژن‌های CYP2C9 و VKORC1 و تعیین حساسیت و مقاومت به وارفارین در جمعیت جنوب ایران [PDF]

مجله دانشکده پزشکی اصفهان, 2023
مقاله پژوهشیمقدمه: از سال ۱۹۵۰، وارفارین به‌عنوان ضد انعقاد برای درمان و پیشگیری از شرایط ترومبوآمبولی استفاده می‌شود. عوامل مختلفی همچون سن، وزن، رژیم غذایی و عوامل ژنتیکی مثل ژن  CYP2C9وVKORC1 در تعیین دوز وارفارین مؤثر هستند.
جواد جهانگیری, بابک شیرازی یگانه, اردشیر بهمنی   +2 more
doaj   +1 more source

An HMM-based Comparative Genomic Framework for Detecting Introgression in Eukaryotes [PDF]

, 2013
One outcome of interspecific hybridization and subsequent effects of evolutionary forces is introgression, which is the integration of genetic material from one species into the genome of an individual in another species.
Dai, Jingxuan, Kohn, Michael H., Liu, Kevin J., Nakhleh, Luay, Song, Ying, Truong, Kathy   +5 more
core   +2 more sources

The influence of clinical and genetic factors on the stability of warfarin’s anticoagulant effect in patients with atrial fibrillation

Patologìâ, 2022
The aim. To investigate the influence of clinical and genetic factors on the stability of warfarin’s anticoagulant effect in patients with atrial fibrillation (AF) during the year. Materials and methods.
Ya. M. Mykhailovskyi
doaj   +1 more source

Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]

, 2011
Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core   +1 more source