Pharmacogenomics in children: advantages and challenges of next generation sequencing applications [PDF]
, 2013 Pharmacogenetics is considered as a prime example of how personalized medicine nowadays can be put into practice. However, genotyping to guide pharmacological treatment is relatively uncommon in the routine clinical practice. Several reasons can be found
De Paepe, Anne, Vanakker, Olivier
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Correction: GGCX and VKORC1 inhibit osteocalcin endocrine functions [PDF]
Journal of Cell Biology, 2019 Vol. 208, No. 6, March 16, 2015. [10.1083/jcb.201409111][1]. The authors noticed a mistake in the labeling of the genotyping primers in Fig. S1 A and Table S1. In Fig. S1 A, the primers P1 and P2 are actually flanking the 5′loxP site region.
Ferron, Mathieu +4 more
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The Effect of CYP2C9 and VKORC1 Genetic Polymorphism on Warfarin Dose Requirements in a Sample of Iraqi Patients [PDF]
Journal of Kerman University of Medical Sciences, 2021 Background: Warfarin is the most widely used oral anticoagulant for the prevention and treatment of thromboembolic disorders. Because of narrow therapeutic index and various genetic and non-genetic factors that influence the disposition of the drug, its ...
Maha Ali Saleh +4 more
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The c.-1639g>A polymorphism of the VKORC1 gene and his influence on the therapeutic response during oral anticoagulants use [PDF]
, 2009 Background/Aim. A single nucleotide polymorphism c.- 1639G>A in the promoter region of vitamin K-epoxide reductase (VKORC1) gene has been found to account for most of the variability in response to oral anticoagulants (OA). The aim of the study was to
Kovač Mirjana +3 more
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A New Nested Allele-Specific Multiplex Polymerase Chain Reaction Method for Haplotyping of VKORC1 Gene to Predict Warfarin Sensitivity [PDF]
, 2014 The vitamin K epoxide reductase complex 1 gene (VKORC1) is commonly assessed to predict warfarin sensitivity. In this study, a new nested allele-specific multiplex polymerase chain reaction (PCR) method that can simultaneously identify single ...
Abdullah, Wan Zaidah +3 more
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PLoS ONE, 2010 Osteoporosis, defined by low bone mineral density (BMD), is common among postmenopausal women. The distribution of BMD varies across populations and is shaped by both environmental and genetic factors.
Dana C Crawford +2 more
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Vitamin K epoxide reductase complex subunit 1 (
BMC Research Notes, 2008 Background Polymorphisms in the vitamin K-epoxide reductase complex subunit 1 gene, Vkorc1, could affect blood coagulation and other vitamin K-dependent proteins, such as osteocalcin (bone Gla protein, BGP).
Kohn Michael H, Vera Nicole, Song Ying
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The influence of genotype on warfarin maintenance dose predictions produced using a Bayesian dose individualization tool [PDF]
, 2016 Background A previously established Bayesian dosing tool for warfarin was found to produce biased maintenance dose predictions. In the following study, we aimed to (1) determine if the biased warfarin dose predictions previously observed could be ...
Anderson +37 more
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VKORC1 and CYP2C9 polymorphisms related to adverse events in case-control cohort of anticoagulated patients [PDF]
, 2016 Vitamin K antagonists (VKAs) are highly effective but have a narrow therapeutic index and require routine monitoring of the INR. The primary aim of pharmacogenetics (PGx) is to optimize patient care, achieving drug treatments that are personalized ...
Caimi, Luigi +8 more
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Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin [PDF]
Genetics in Medicine, 2008 American College of Medical Genetics statements and guidelines are designed primarily as an educational resource for medical geneticists and other health care professionals to help them provide quality medical genetic services. Adherence to these standards and guidelines does not necessarily ensure a successful medical outcome.
David A, Flockhart +14 more
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