Results 51 to 60 of about 7,461 (205)

Implications of Polymorphisms in the BCKDK and GATA‐4 Gene Regions on Stable Warfarin Dose in African Americans

Clinical and Translational Science, 2021
VKORC1 and CYP2C9 genotypes explain less variability in warfarin dose requirements in African Americans compared with Europeans. Variants in BCKDK and GATA‐4 gene regions, purported to regulate VKORC1 and CYP2C9 expression, have been shown to play an ...
Salma A. Bargal, Jennifer N. Kight, Felipe Augusto de Oliveira, Mohamed H. Shahin, Taimour Langaee, Yan Gong, Issam S. Hamadeh, Rhonda M. Cooper-DeHoff, Larisa H. Cavallari   +8 more
doaj   +1 more source

A multi-factorial analysis of response to warfarin in a UK prospective cohort [PDF]

, 2016
Background Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response.
A Holbrook, A Rouaud, AE Rettie, AH Maitland-van der Zee, AK Hamberg, AL Jorgensen, AL Jorgensen, Andrea Jorgensen, Anita Hanson, Ann K. Daly, AR Tabrizi, BN Howie, BS Finkelman, C Barnes, Cheng Hock Toh, DR Plowchalk, Eunice J. Zhang, F Takeuchi, F Xu, Farhad Kamali, G D’Andrea, GP Aithal, H Furuya, HY Yuan, J Marchini, JB Saunders, L Poller, M Connock, M Ohara, M Pirmohamed, M Pirmohamed, M Wadelius, M Wadelius, M Wadelius, M Wadelius, MA Crowther, Matthew S. Gillman, MD Caldwell, MI Aguilar, MJ Rieder, MT Lee, Munir Pirmohamed, NA Limdi, P Lenzini, Panos Deloukas, Paula Williamson, PJ Avery, R Loebstein, S Purcell, SE Kimmel, SK Ganesh, Stephane Bourgeois, Suzannah Bumpstead, VC Oliveira Almeida de, WE Nostrand Van, YY Teo   +55 more
core   +3 more sources

Common VKORC1 and GGCX polymorphisms associated with warfarin dose [PDF]

The Pharmacogenomics Journal, 2005
We report a novel combination of factors that explains almost 60% of variable response to warfarin. Warfarin is a widely used anticoagulant, which acts through interference with vitamin K epoxide reductase that is encoded by VKORC1. In the next step of the vitamin K cycle, gamma-glutamyl carboxylase encoded by GGCX uses reduced vitamin K to activate ...
M, Wadelius, L Y, Chen, K, Downes, J, Ghori, S, Hunt, N, Eriksson, O, Wallerman, H, Melhus, C, Wadelius, D, Bentley, P, Deloukas   +10 more
openaire   +2 more sources

The prevalence of VKORC1 alleles in the population of the Republic of Srpska, Bosnia and Herzegovina [PDF]

Scripta Medica, 2023
Background/Aim: Warfarin is one of the most common orally prescribed anticoagulant in patients with deep venous thrombosis, myocardial or cerebral infarctions. The main side effects of non-adequate dose of these drugs are prolonged peripheral or internal
Vidović Vanja, Bećarević Jelena, Radić-Savić Žana, Marić Aljoša, Vidović Stojko, Milovac Irina, Maksimović Nela   +6 more
doaj  

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update [PDF]

, 2017
This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing.
Anderson, JL, Caudle, KE, Cavallari, LH, Gage, BF, Gong, L, Johnson, JA, Kimmel, SE, Klein, TE, Lee, MT, Limdi, NA, Perera, MA, Pirmohamed, M, Scott, SA, Stein, CM, Wadelius, M, Whirl-Carrillo, M   +15 more
core   +1 more source

VKORC1 ER mislocalization causes rare disease

Blood, 2014
In this issue of Blood , Czogalla et al identify that the rare heritable hemorrhaging disease, vitamin K–dependent clotting factor deficiency type 2 (VKCFD2), is caused by mislocalization of vitamin K epoxide reductase (VKORC1) in the endoplasmic reticulum (ER).[1][1] ![Figure][2 ...
openaire   +3 more sources

APPLICATIONS OF PHARMACOGENETIC TESTING FOR PERSONALIZATION OF THERAPY WITH ORAL ANTICOAGULANTS IN RUSSIA

Рациональная фармакотерапия в кардиологии, 2015
The clinical significance of the patient genetic characteristics in the individual pharmacological response to oral anticoagulants is considered. Possible tactics of warfarin dosing and new oral anticoagulants choice on the basis of pharmacogenetic ...
D. A. Sychev, R. E. Kazakov, V. A. Otdelenov, A. B. Prokofiev   +3 more
doaj   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 953-963, April 2026.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Adaptive introgressive hybridization with the Algerian mouse (Mus spretus) promoted the evolution of anticoagulant rodenticide resistance in European house mice (M. musculus domesticus)

Julius-Kühn-Archiv, 2011
Adaptive introgressive hybridization refers to the natural transfer of genes after interspecific mating between species, and subsequent expression of these genes in the recipient species as a new trait that confers selective advantages. Conceptually, the
Song, Y., Endepols, S., Klemann, N., Richter, D., Matuschka, F.-R., Shih, C.-H., Nachman, M. W., Kohn, M. H.   +7 more
doaj   +1 more source