Results 21 to 30 of about 132,798 (291)
Contribution of Axon Initial Segment Structure and Channels to Brain Pathology
Cells, 2023 Brain channelopathies are a group of neurological disorders that result from genetic mutations affecting ion channels in the brain. Ion channels are specialized proteins that play a crucial role in the electrical activity of nerve cells by controlling ...
Juan José Garrido
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Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels. [PDF]
Elife, 2016 Voltage-gated ion channels mediate electrical dynamics in excitable tissues and are an important class of drug targets. Channels can gate in sub-millisecond timescales, show complex manifolds of conformational states, and often show state-dependent ...
Zhang H, Reichert E, Cohen AE.
europepmc +2 more sources
Voltage gated inter-cation selective ion channels from graphene nanopores [PDF]
, 2019 With the ability to selectively control ionic flux, biological protein ion channels perform a fundamental role in many physiological processes. For practical applications that require the functionality of a biological ion channel, graphene provides a ...
Bedworth, Peter V. +10 more
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Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel [PDF]
, 2013 The crystal structure of the open conformation of a bacterial voltage-gated sodium channel pore from Magnetococcus sp. (NaVMs) has provided the basis for a molecular dynamics study defining the channel’s full ion translocation pathway and conductance ...
Bagneris, Claire +7 more
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Dual Regulation of Voltage-Sensitive Ion Channels by PIP2
Frontiers in Pharmacology, 2012 Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidilinositol 4,5-bisphosphate (PIP2). Among them are voltage-gated channels, which are crucial
Aldo A Rodríguez Menchaca +3 more
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Hysteretic Behavior in Voltage-Gated Channels
Frontiers in Pharmacology, 2020 An ever-growing body of evidence has shown that voltage-gated ion channels are likely molecular systems that display hysteresis in their activity. This phenomenon manifests in the form of dynamic changes in both their voltage dependence of activity and ...
Carlos A. Villalba-Galea, Alvin T. Chiem
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An Improved Method for Modeling Voltage-Gated Ion Channels at Atomic Accuracy Applied to Human Cav Channels. [PDF]
Cell Rep, 2018 Summary: Voltage-gated ion channels (VGICs) are associated with hundreds of human diseases. To date, 3D structural models of human VGICs have not been reported.
Martinez-Ortiz W, Cardozo TJ.
europepmc +2 more sources
Frontiers in Pharmacology, 2012 Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1-S6), with each S1-S4 segments forming a voltage-sensing domain (VSD) and the four S5-S6 forming both the conduction pathway and its gate.
Frank S Choveau +17 more
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Lipid ion channels and the role of proteins [PDF]
, 2013 Synthetic lipid membranes in the absence of proteins can display quantized conduction events for ions that are virtually indistinguishable from those of protein channel. By indistinguishable we mean that one cannot decide based on the current trace alone
Heimburg, Thomas, Mosgaard, Lars D.
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Voltage sensing in ion channels: Mesoscale simulations of biological devices [PDF]
, 2012 Electrical signaling via voltage-gated ion channels depends upon the function of a voltage sensor (VS), identified with the S1-S4 domain in voltage-gated K+ channels.
A. Hodgkin +4 more
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