Results 41 to 50 of about 2,241,154 (143)

Voltage-Gated Sodium Channel Dysfunction in Epilepsy: Zebrafish Models for Therapeutics

Biomedicines
Voltage-gated sodium channels (VGSCs) play pivotal roles in cellular function, particularly in the regulation of electrical signaling. Structural defects in these channels cause deleterious effects in a myriad of cell types, leading to various diseases ...
Angela Gyamfi, Priyadharshini Manikandan, William A. Cisneros, Theodore R. Cummins, James A. Marrs   +4 more
doaj   +1 more source

Ubiquitylation of voltage-gated sodium channels.

, 2014
Ion channel proteins are regulated by different types of posttranslational modifications. The focus of this review is the regulation of voltage-gated sodium channels (Navs) upon their ubiquitylation.
Cédric J. Laedermann, Hugues Abriel, Decosterd, I., Decosterd, Isabelle, Abriel, H., Laedermann, Cédric J, Isabelle Decosterd, Abriel, Hugues, Laedermann, C.J., Laedermann CJ, Decosterd I, Abriel H   +11 more
core   +1 more source

Voltage-gated sodium channels as targets for pyrethroid insecticides [PDF]

, 2017
The pyrethroid insecticides are a very successful group of compounds that have been used extensively for the control of arthropod pests of agricultural crops and vectors of animal and human disease.
Field, L.M., Williamson, M.S., Wallace, Bonnie A., Field, LM, Davies, TGE, O'Reilly, AO, Wallace, B. A., Emyr Davies, T.G., Field, L. M., Wallace, BA, Williamson, MS, O’Reilly, A.O., O'Reilly, A. O., Davies, T. G. E., Williamson, M. S., T. G. Emyr Davies, Davies, Emyr, Linda M. Field, Andrias O. O’Reilly, B. A. Wallace, Martin S. Williamson, Field, Lin, Williamson, Martin   +22 more
core   +2 more sources

Effects of Benzothiazolamines on Voltage-Gated Sodium Channels

, 2017
Benzothiazole is a versatile fused heterocycle that aroused much interest in drug discovery as anticonvulsant, neuroprotective, analgesic, anti-inflammatory, antimicrobial, and anticancer.
Desaphy, Jean-François, Alessandro Farinato, Jean-François Desaphy, Altamura, Concetta, Farinato, Alessandro, Concetta Altamura   +5 more
core   +1 more source

Ion channel gradients in the apical tuft region of CA1 pyramidal neurons. [PDF]

PLoS ONE, 2012
Dendritic ion channels play a critical role in shaping synaptic input and are fundamentally important for synaptic integration and plasticity. In the hippocampal region CA1, somato-dendritic gradients of AMPA receptors and the hyperpolarization-activated
Katie C Bittner, Bertalan K Andrasfalvy, Jeffrey C Magee   +2 more
doaj   +1 more source

The structure of a voltage gated potassium channel

, 2010
Voltage gated potassium channels (Kv channels) are tetrameric ion channels, responsible for regulating the potassium component of the membrane potential in a large range of cell types ranging from mammalian excitable cells to bacteria. Attempts have been
Rogers, Nik
core   +1 more source

Molecular Surface of JZTX-V (β-Theraphotoxin-Cj2a) Interacting with Voltage-Gated Sodium Channel Subtype NaV1.4

Toxins, 2014
Voltage-gated sodium channels (VGSCs; NaV1.1–NaV1.9) have been proven to be critical in controlling the function of excitable cells, and human genetic evidence shows that aberrant function of these channels causes channelopathies, including epilepsy ...
Ji Luo, Yiya Zhang, Mengting Gong, Shanshan Lu, Yifeng Ma, Xiongzhi Zeng, Songping Liang   +6 more
doaj   +1 more source

Voltage-gated ion channels and gating modifier toxins. [PDF]

, 2007
International audienceVoltage-gated sodium, calcium, and potassium channels generate electrical signals required for action potential generation and conduction and are the molecular targets for a broad range of potent neurotoxins.
Scheuer, Todd, Yu, Frank, Catterall, William,, Cestèle, Sandrine, Konoki, Keiichi, Catterall, William, A., Yu, Frank, H., Yarov-Yarovoy, Vladimir, Yu, Frank,   +8 more
core   +1 more source

Electrophysiological modulation of pain‑related sodium channels by cannabinoids: a systematic review

Journal of Cannabis Research
Background Voltage-gated sodium channels regulate dorsal root ganglion excitability and are critical for nociceptive transmission. Cannabidiol (CBD) and related phytocannabinoids have been proposed to modulate these channels, offering potential non ...
Samuel Gonçalves Castro, Sarah Eduarda Silva, Julio Cesar Moreira Brito, Alessandra Matavel   +3 more
doaj   +1 more source

Differential lipid dependence of the function of bacterial sodium channels.

PLoS ONE, 2013
The lipid bilayer is important for maintaining the integrity of cellular compartments and plays a vital role in providing the hydrophobic and charged interactions necessary for membrane protein structure, conformational flexibility and function.
Nazzareno D'Avanzo, Emily C McCusker, Andrew M Powl, Andrew J Miles, Colin G Nichols, B A Wallace   +5 more
doaj   +1 more source