Results 61 to 70 of about 2,241,154 (143)

Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold

Channels
Ion channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and ...
Phuong Tran Nguyen, Brandon John Harris, Diego Lopez Mateos, Adriana Hernández González, Adam Michael Murray, Vladimir Yarov-Yarovoy   +5 more
doaj   +1 more source

Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

eLife, 2014
Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for cation/proton antiporters ...
Paul G DeCaen, Yuka Takahashi, Terry A Krulwich, Masahiro Ito, David E Clapham   +4 more
doaj   +1 more source

Predictive 3D modelling of the interactions of pyrethroids with the voltage-gated sodium channels of ticks and mites

, 2014
Background: The pyrethroid insecticides are a very successful group of compounds that target invertebrate voltage-gated sodium channels and are widely used in the control of insects, ticks and mites.
Field, L.M., Williamson, M.S., González-Cabrera, J., Wallace, Bonnie A., Gozalez-Cabrera, J., Wallace, B. A., Turberg, A., Emyr Davies, T.G., Field, L. M., O'Reilly, A.O., O'Reilly, A. O., Davies, T. G. E., Williamson, M. S., Davies, Emyr, Williamson, Martin, Field, Lin   +15 more
core   +1 more source

Voltage-Dependent Ion Channels in Vascular Endothelial Cells: An Unexpected Signaling Pathway in Non-Excitable Cells

Biomedicines
Voltage-gated ion channels (VGICs) are traditionally associated with electrically excitable cells; however, increasing evidence indicates that they are also expressed in non-excitable cells, including vascular endothelial cells.
Francesco Moccia, Teresa Soda
doaj   +1 more source

The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

Frontiers in Cellular Neuroscience, 2017
Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of ...
Jeffrey Lopez-Rojas, Maël Duménieu, Marie Oulé, Michael R. Kreutz, Michael R. Kreutz   +4 more
doaj   +1 more source

Expression of voltage-gated sodium and calcium channels in T4/T5 neurons.

, 2016
RPKM values of the identified structural and modulatory subunits of voltage-gated sodium and calcium channels are plotted on a color scale ranging from 0 to 100 RPKM.
Katarina Pankova (3185907), Alexander Borst (32619)   +1 more
core   +1 more source

Voltage-gated sodium channels mutations and their role in epilepsy

, 2022
International audienceVoltage-gated ion channels play a pivotal role in cell signaling. They are responsible for generating action potential and repolarization.
Witkowski, Grzegorz, Patyra, Andrzej
core   +1 more source

VKCDB: Voltage-gated potassium channel database [PDF]

, 2004
Background: The family of voltage-gated potassium channels comprises a functionally diverse group of membrane proteins. They help maintain and regulate the potassium ion-based component of the membrane potential and are thus central to many critical ...
Li, B., Gallin, W.J.
core   +1 more source

Voltage-gated sodium channels assemble and gate as dimers

Nature Communications, 2017
Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this ...
Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes   +9 more
doaj   +1 more source

Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

Marine Drugs, 2006
Ciguatoxins are cyclic polyether toxins, derived from marine dinoflagellates, which are responsible for the symptoms of ciguatera poisoning. Ingestion of tropical and subtropical fin fish contaminated by ciguatoxins results in an illness characterised by
Richard J. Lewis, Graham M. Nicholson
doaj   +1 more source