MODULATION OF NOCICEPTION BY VOLTAGE GATED SODIUM ION CHANNELS IN THE TORTOISE (Kinixys spekii)
, 2020 The project is about investigating the involvement of several voltage gated sodium ion channels on nociception in the speke hinged tortoise.
Christopher Musembi Makau
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Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies
Frontiers in Pharmacology, 2012 Voltage-gated sodium channels (VGSC) are multi-molecular protein complexes expressed in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi-spanning integral membrane glycoprotein (α-subunit) that can be associated ...
Eleonora eSavio Galimberti +2 more
doaj +1 more source
Voltage-gated sodium channels dysfunction in depression: the hypothesis
Psychiatry and Behavioral Sciences, 2016 Voltage-gated sodium (Na+) channels (VGSCs) are responsible for action potential initiation and propagation in most electrically excitable cells which are implicated in a wide range physiological functions including neuronal signalling, muscle ...
Osman Ozdemir
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Alzheimer's secretases regulate voltage-gated sodium channels
, 2010 BACE1 and presenilin (PS)/γ-secretase are primary proteolytic enzymes responsible for the generation of pathogenic amyloid β-peptides (Aβ) in Alzheimer's disease. We and others have found that β-subunits of the voltage-gated sodium channel (Na(v)βs) also
Gersbacher, M T +5 more
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MODULATION OF NOCICEPTION BY VOLTAGE GATED SODIUM ION CHANNELS IN THE TORTOISE (Kinixys spekii)
, 2021 The project is about investigating the involvement of several voltage gated sodium ion channels (Nav1.3, Nav1.7 and Nav1.8) on nociception in the speke hinged tortoise.
Christopher Musembi Makau
core +1 more source
Potential roles of voltage-gated ion channel disruption in Tuberous Sclerosis Complex
Frontiers in Molecular NeuroscienceTuberous Sclerosis Complex (TSC) is a lynchpin disorder, as it results in overactive mammalian target of rapamycin (mTOR) signaling, which has been implicated in a multitude of disease states.
Hailey X. Egido-Betancourt +2 more
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Sodium channels and mammalian sensory mechanotransduction
Molecular Pain, 2012 Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin +7 more
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KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition [PDF]
, 2011 Voltage-gated potassium (Kv) currents generated by N-type α-subunit homotetramers inactivate rapidly because an N-terminal ball domain blocks the channel pore after activation.
Abbott, G. +10 more
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Microbial Voltage-gated Ion Channels
, 2021 Voltage-gated ion channels (VIC) form a superfamily that is well known for transporting potassium, sodium and calcium ions in excitable tissues. Ancestral members of this superfamily were thought to transport only potassium ions, unlike modern homologs ...
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Propranolol blocks cardiac and neuronal voltage-gated sodium channels
Frontiers in Pharmacology, 2010 Propranolol is a widely-used, nonselective ß-adrenergic receptor antagonist with proven efficacy in treating cardiovascular disorders and in the prevention of migraine headaches.
Dao W Wang +7 more
doaj +1 more source