vsgseq2: an updated pipeline for analysis of the diversity and abundance of population-wide Trypanosoma brucei VSG expression [version 1; peer review: 2 approved] [PDF]
Wellcome Open ResearchTrypanosoma brucei is an extracellular eukaryotic parasite that causes sleeping sickness in humans and Nagana, Surra and Dourine in livestock, game animals and horses.
Stephen Larcombe +4 more
doaj +2 more sources
Gut microbiome shifts in adolescents after sleeve gastrectomy with increased oral-associated taxa and pro-inflammatory potential [PDF]
Gut MicrobesBariatric surgery is highly effective in achieving weight loss in children and adolescents with severe obesity, however the underlying mechanisms are incompletely understood, and gut microbiome changes are unknown.
Cynthia O. Akagbosu +22 more
doaj +2 more sources
Frequency control of voltage sourced converter-based multi-terminal direct current interconnected system based on virtual synchronous generator [PDF]
Archives of Electrical Engineering, 2023 In response to the inability of the flexible DC transmission system connected to the AC grid under conventional control strategies to provide inertia to the system as well as to participate in frequency regulation, a virtual synchronous generator (VSG ...
Congshan Li +4 more
doaj +1 more source
Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies. [PDF]
PLoS Pathogens, 2016 The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at ...
Jackie L Y Cheung +5 more
doaj +1 more source
Turnover of Variant Surface Glycoprotein in
mBio, 2021 African trypanosomes utilize glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) to evade the host immune system. VSG turnover is thought to be mediated via cleavage of the GPI anchor by endogenous GPI-specific phospholipase C (
Paige Garrison +9 more
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Vertical sleeve gastrectomy induces distinctive transcriptomic responses in liver, fat and muscle
Scientific Reports, 2021 Vertical sleeve gastrectomy (VSG) is the most commonly performed bariatric/metabolic surgery, exhibiting a high rate of diabetes remission in humans. To elucidate the molecular mechanisms of VSG, we performed transcriptomic analysis of the liver, fat ...
Chang Ho Ahn +5 more
doaj +1 more source
VSG mRNA levels are regulated by the production of functional VSG protein
Molecular and Biochemical Parasitology, 2021 The bloodstream form of Trypanosoma brucei persists in mammalian hosts through a population survival strategy depending on antigenic variation of a cell surface coat composed of the variant surface glycoprotein (VSG). The integrity of the VSG coat is essential and blocking its synthesis results in a cell division cycle arrest just prior to cytokinesis.
Maudlin, Isabella E +3 more
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IET Smart Grid, 2020 In this study, virtual excitation emulation (VEE) is proposed along with the virtual inertia emulation (VIE) for a virtual synchronous generator (VSG) in a standalone microgrid to improve the AC voltage and frequency profile through the control of power ...
Soumya Samanta +3 more
doaj +1 more source
Escaping the immune system by DNA repair and recombination in African trypanosomes [PDF]
Open Biology, 2019 African trypanosomes escape the mammalian immune response by antigenic variation—the periodic exchange of one surface coat protein, in Trypanosoma brucei the variant surface glycoprotein (VSG), for an immunologically distinct one.
Núria Sima +3 more
doaj +1 more source
Pathogens, 2021 Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response.
Bibo Li, Yanxiang Zhao
doaj +1 more source