Results 11 to 20 of about 5,785 (167)

Pedal to the Metal: Nuclear Splicing Bodies Turbo-Charge VSG mRNA Production in African Trypanosomes

Frontiers in Cell and Developmental Biology, 2022
The African trypanosome Trypanosoma brucei is a parasite of the mammalian bloodstream and tissues, where an antigenically variable Variant Surface Glycoprotein (VSG) coat protects it from immune attack.
James Budzak, Gloria Rudenko
doaj   +1 more source

Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists Following Bariatric Surgery: A Systematic Review and Meta-Analysis. [PDF]

Endocrinol Diabetes Metab
GLP‐1 receptor agonists significantly improved weight loss, BMI, HbA1c, and cholesterol in patients after bariatric surgery, supporting their role in enhancing postoperative metabolic outcomes. ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) have demonstrated promising effects in promoting weight loss and improving metabolic ...
Bilal AR, Ibrahim M, Arfin SMW, Bilal AR, Balach R, Qureshi S, Gaba H, Collins P, Ahmed R, Waqas SA.   +9 more
europepmc   +2 more sources

SUMOylation by the E3 ligase TbSIZ1/PIAS1 positively regulates VSG expression in Trypanosoma brucei. [PDF]

PLoS Pathogens, 2014
Bloodstream form trypanosomes avoid the host immune response by switching the expression of their surface proteins between Variant Surface Glycoproteins (VSG), only one of which is expressed at any given time.
Diana López-Farfán, Jean-Mathieu Bart, Domingo I Rojas-Barros, Miguel Navarro   +3 more
doaj   +1 more source

Universal Virtual Synchronous Generator Based on Extended Virtual Inertia to Enhance Power and Frequency Response

Energies, 2023
Virtual synchronous generators (VSG) are considered a new generation of grid-friendly inverters with the same inertial support characteristics as synchronous generators (SG). However, the inertia support comes with the side effects of power and frequency
Hao Liu, Bo Yang, Song Xu, Mingjian Du, Shuai Lu   +4 more
doaj   +1 more source

Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

mBio, 2022
In the mammalian host, Trypanosoma brucei is coated in a single-variant surface glycoprotein (VSG) species. Stochastic switching of the expressed VSG allows the parasite to escape detection by the host immune system.
Emilia Jane McLaughlin, Karinna Rubio-Pena, Annick Dujeancourt-Henry, Lucy Glover   +3 more
doaj   +1 more source

Control of Variant Surface Glycoprotein Expression by CFB2 in Trypanosoma brucei and Quantitative Proteomic Connections to Translation and Cytokinesis

mSphere, 2022
Variant surface glycoproteins (VSGs) coat parasitic African trypanosomes and underpin antigenic variation and immune evasion. These VSGs are superabundant virulence factors that are subject to posttranscriptional gene expression controls mediated via the
Gustavo Bravo Ruiz, Michele Tinti, Melanie Ridgway, David Horn   +3 more
doaj   +1 more source

Modification of Control System Based on Virtual Synchronous Generator with Feedforward Control for Power Converters of Distributed Generation [PDF]

E3S Web of Conferences
An important development trend for modern power systems is the application of control algorithms for power converters based on a virtual synchronous generator (VSG), which can mimic the characteristics of the conventional synchronous generation and ...
Askarov Alisher, Ufa Ruslan, Suvorov Aleksey, Kievets Anton   +3 more
doaj   +1 more source

Functional insights from a surface antigen mRNA-bound proteome

eLife, 2021
Trypanosoma brucei is the causative agent of human sleeping sickness. The parasites’ variant surface glycoprotein (VSG) enables them to evade adaptive immunity via antigenic variation. VSG comprises 10% of total cell protein and the high stability of VSG
Larissa Melo do Nascimento, Franziska Egler, Katharina Arnold, Nina Papavasiliou, Christine Clayton, Esteban Erben   +5 more
doaj   +1 more source

PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes

eLife, 2023
African trypanosomes evade host immune clearance by antigenic variation, causing persistent infections in humans and animals. These parasites express a homogeneous surface coat of variant surface glycoproteins (VSGs).
Abdoulie O Touray, Rishi Rajesh, Tony Isebe, Tamara Sternlieb, Mira Loock, Oksana Kutova, Igor Cestari   +6 more
doaj   +1 more source

Improved Virtual Synchronous Generator-Based Control Scheme for Enhanced Transient Response in Microgrids

Engineering Proceedings, 2023
Synchronous generator-based power stations, with their inherent inertia, can maintain frequency stability during sudden load switching, while distributed generating station-driven microgrids suffer from a lack of natural inertia. Cascaded power, voltage,
Mandarapu Srikanth, Yellapragada Venkata Pavan Kumar   +1 more
doaj   +1 more source