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The Journal of Cell Biology, 2006 ![Graphic][1] Extended organelle form (left) is needed for later correct function. CUTLER/ELSEVIERFollowing blood vessel injury, long strings of multimeric von Willebrand's factor (VWF) act as a scaffold for platelets to help staunch bleeding. The VWF strings, 100-μm long or more,
William A. Wells
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VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease [PDF]
Blood, 2013 Key Points VWFpp/VWF:Ag and FVIII:C/VWF:Ag ratios define the pathophysiological mechanisms that play a role in VWD and various VWF mutations. A high VWFpp/VWF:Ag ratio indicates increased clearance of VWF and a high FVIII:C/VWF:Ag ratio decreased synthesis of VWF.
J. Eikenboom +11 more
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Comorbidities associated with higher von Willebrand factor (
British Journal of Haematology, 2018 Some comorbidities, such as hypertension, are associated with higher von Willebrand factor (VWF) levels in the general population. No studies have been conducted to assess this association in patients with von Willebrand disease (VWD).
Ferdows Atiq +14 more
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Blood Advances, 2018 : Plasma levels of von Willebrand factor (VWF) vary considerably in the general population and this variation has been linked to several genetic and environmental factors. Genetic factors include 2 common single nucleotide variants (SNVs) located in VWF,
Ahmad H. Mufti +11 more
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SHEARiO, fast lane to oxidized VWF [PDF]
Blood, 2011 In this issue of Blood , Fu and coworkers show that shear stress–induced conformational changes in VWF allow the exposure of otherwise buried methionine residues, thereby promoting their susceptibility to oxidation. 1 Methionine oxidation importantly alters the interaction between VWF and platelets and prevents degradation of the protein by ADAMTS13.
Peter J. Lenting
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Blood, 2006 Comment on Lisman et al, page [3753][1] In this issue of Blood , Lisman and colleagues report on the identification of the VWF-binding site within collagen III: of 57 triple-helical peptides spanning the whole triple-helical domain, one single 27-residue collagen III sequence, with an essential 9-
Hans Deckmyn, Karen Vanhoorelbeke
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Protein superglue that holds VWF together [PDF]
Blood, 2014 In this issue of Blood , Zhou and Springer report on the structure determination of the von Willebrand factor (VWF) C-terminal cysteine knot domain (CTCK), finally uncovering the structural basis for the super-stable CTCK dimer that underpins platelet adhesion.[1][1] ![Figure][2] VWF is ...
Zongchao Jia
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Sugar targets VWF for the chop [PDF]
Blood, 2010 In this issue of Blood , McGrath et al provide new insights into the influence of glycosylation on VWF proteolysis by ADAMTS13.[1][1] Von Willebrand factor (VWF) is synthesized in vascular endothelial cells and megakaryocytes and undergoes extensive processing prior to secretion.
D. J. Bowen
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CURRENT KNOWLEDGE ON THE PATHOGENIC MECHANISMS OF HENOCH-SCHOENLEIN PURPURA IN CHILDREN [PDF]
Trakia Journal of Sciences, 2021 The Schӧnlein-Henoch vasculitis is an IgA-mediated inflammation of small vessels. The main clinical manifestation is palpable purpura without thrombocytopenia, manifested by bilateral symmetrical distribution on both lower limbs, abdominal pain, often ...
A.Vasileva, Iv. Chakarov, P. Chakarova
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Impaired exercise capacity in post–COVID-19 syndrome: the role of VWF-ADAMTS13 axis
Blood Advances, 2022 Key Points A VWF(Ag)/ADAMTS13 ratio ≥1.5 was evident in 28% of the PCS cohort. Of the patients with impaired exercise capacity, 55% had a VWF(Ag)/ADAMTS13 ratio ≥1.5 (odds ratio, 4).
Nithya Prasannan +11 more
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