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The Journal of Cell Biology, 2006 ![Graphic][1] Extended organelle form (left) is needed for later correct function. CUTLER/ELSEVIERFollowing blood vessel injury, long strings of multimeric von Willebrand's factor (VWF) act as a scaffold for platelets to help staunch bleeding. The VWF strings, 100-μm long or more,
William A. Wells
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Blood, 2006 Comment on Lisman et al, page [3753][1] In this issue of Blood , Lisman and colleagues report on the identification of the VWF-binding site within collagen III: of 57 triple-helical peptides spanning the whole triple-helical domain, one single 27-residue collagen III sequence, with an essential 9-
Hans Deckmyn, Karen Vanhoorelbeke
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Sugar targets VWF for the chop [PDF]
Blood, 2010 In this issue of Blood , McGrath et al provide new insights into the influence of glycosylation on VWF proteolysis by ADAMTS13.[1][1] Von Willebrand factor (VWF) is synthesized in vascular endothelial cells and megakaryocytes and undergoes extensive processing prior to secretion.
D. J. Bowen
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SHEARiO, fast lane to oxidized VWF [PDF]
Blood, 2011 In this issue of Blood , Fu and coworkers show that shear stress–induced conformational changes in VWF allow the exposure of otherwise buried methionine residues, thereby promoting their susceptibility to oxidation. 1 Methionine oxidation importantly alters the interaction between VWF and platelets and prevents degradation of the protein by ADAMTS13.
Peter J. Lenting
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Protein superglue that holds VWF together [PDF]
Blood, 2014 In this issue of Blood , Zhou and Springer report on the structure determination of the von Willebrand factor (VWF) C-terminal cysteine knot domain (CTCK), finally uncovering the structural basis for the super-stable CTCK dimer that underpins platelet adhesion.[1][1] ![Figure][2] VWF is ...
Zongchao Jia
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CURRENT KNOWLEDGE ON THE PATHOGENIC MECHANISMS OF HENOCH-SCHOENLEIN PURPURA IN CHILDREN [PDF]
Trakia Journal of Sciences, 2021 The Schӧnlein-Henoch vasculitis is an IgA-mediated inflammation of small vessels. The main clinical manifestation is palpable purpura without thrombocytopenia, manifested by bilateral symmetrical distribution on both lower limbs, abdominal pain, often ...
A.Vasileva, Iv. Chakarov, P. Chakarova
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Prognostic value of von Willebrand factor in clinical practice
Акушерство, гинекология и репродукция, 2022 The von Willebrand factor (vWF) is a multimeric plasma glycoprotein, which quantification has important prognostic value. The current literature review demonstrates a relationship between the disease severity and vWF level.
K. N. Grigoreva +12 more
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Акушерство, гинекология и репродукция, 2023 Introduction. Neutrophil extracellular traps (NETs) and von Willebrand factor (vWF) are integral players in thrombosis and inflammation in cancer patients. It has been increasingly evident that an active interplay exists between NETs and vWF.
E. V. Slukhanchuk +10 more
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Platelets, 2023 ADAMTS13 is a plasma metalloprotease with the primary function of cleaving VWF to maintain hemostasis. Circulating ADAMTS13 is in the closed conformation until blood vessel injury triggers a VWF-dependant activation to the open active form of the protein.
Zoe Markham-Lee +2 more
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Neonatal thrombosis: risk factors and principles of prophylaxis
Акушерство, гинекология и репродукция, 2021 Data analysis on the pathogenesis and risk factors of neonatal thrombosis was carried out. The main risk factor of any neonatal thrombosis is central catheter installment, but other maternal, fetal and neonatal factors should be taken into consideration.
A. V. Vorobev +9 more
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