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The Journal of Cell Biology, 2006 ![Graphic][1] Extended organelle form (left) is needed for later correct function. CUTLER/ELSEVIERFollowing blood vessel injury, long strings of multimeric von Willebrand's factor (VWF) act as a scaffold for platelets to help staunch bleeding. The VWF strings, 100-μm long or more,
William A. Wells
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VWF sequence variants: a data goldmine [PDF]
Blood, 2013 In this issue of Blood , Johnsen et al have analyzed the frequency of coding sequence variants in the von Willebrand factor gene ( VWF ) and have identified 7 missense variants independently associated with levels of von Willebrand factor (VWF) or factor VIII (FVIII).
Anne Goodeve
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CURRENT KNOWLEDGE ON THE PATHOGENIC MECHANISMS OF HENOCH-SCHOENLEIN PURPURA IN CHILDREN [PDF]
Trakia Journal of Sciences, 2021 The Schӧnlein-Henoch vasculitis is an IgA-mediated inflammation of small vessels. The main clinical manifestation is palpable purpura without thrombocytopenia, manifested by bilateral symmetrical distribution on both lower limbs, abdominal pain, often ...
A.Vasileva, Iv. Chakarov, P. Chakarova
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VWF, Platelets and the Antiphospholipid Syndrome [PDF]
International Journal of Molecular Sciences, 2021 The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of antiphospholipid antibodies (aPLs). Laboratory criteria for the classification of APS include the detection of lupus anticoagulant (LAC), anti-cardiolipin (aCL) antibodies and anti-β2glycoprotein I (aβ2GPI) antibodies.
Shengshi Huang +3 more
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VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease [PDF]
Blood, 2013 Key Points VWFpp/VWF:Ag and FVIII:C/VWF:Ag ratios define the pathophysiological mechanisms that play a role in VWD and various VWF mutations. A high VWFpp/VWF:Ag ratio indicates increased clearance of VWF and a high FVIII:C/VWF:Ag ratio decreased synthesis of VWF.
J. Eikenboom +11 more
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Platelets, 2023 ADAMTS13 is a plasma metalloprotease with the primary function of cleaving VWF to maintain hemostasis. Circulating ADAMTS13 is in the closed conformation until blood vessel injury triggers a VWF-dependant activation to the open active form of the protein.
Zoe Markham-Lee +2 more
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Prognostic value of von Willebrand factor in clinical practice
Акушерство, гинекология и репродукция, 2022 The von Willebrand factor (vWF) is a multimeric plasma glycoprotein, which quantification has important prognostic value. The current literature review demonstrates a relationship between the disease severity and vWF level.
K. N. Grigoreva +12 more
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Акушерство, гинекология и репродукция, 2023 Introduction. Neutrophil extracellular traps (NETs) and von Willebrand factor (vWF) are integral players in thrombosis and inflammation in cancer patients. It has been increasingly evident that an active interplay exists between NETs and vWF.
E. V. Slukhanchuk +10 more
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Biology Open, 2021 Arf GTPase-Activating proteins (ArfGAPs) mediate the hydrolysis of GTP bound to ADP-ribosylation factors (Arfs), which are critical to form transport intermediates.
Asano Watanabe +13 more
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VWF clearance: it’s glycomplicated [PDF]
Blood, 2018 In this issue of Blood , Ward et al demonstrate that a loss of sialic acids turns von Willebrand factor (VWF) into a ligand for the scavenger-receptor macrophage galactose-type lectin (MGL ...
Denis, Cécile, Lenting, Peter
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