Results 11 to 20 of about 104,334 (371)

Increased VWF and Decreased ADAMTS-13 in COVID-19: Creating a Milieu for (Micro)Thrombosis

Seminars in Thrombosis and Hemostasis, 2021
von Willebrand factor (VWF) is a large adhesive multimeric protein involved in hemostasis. The larger the size (or number of VWF multimers), the greater the functionality of the protein.
E. Favaloro, B. Henry, G. Lippi
semanticscholar   +1 more source

Sustained VWF‐ADAMTS‐13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction

Journal of Thrombosis and Haemostasis, 2022
Prolonged recovery is common after acute SARS‐CoV‐2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown.
H. Fogarty, S. Ward, L. Townsend, E. Karampini, Stephanie Elliott, N. Conlon, J. Dunne, R. Kiersey, A. Naughton, M. Gardiner, M. Byrne, C. Bergin, J. O’Sullivan, I. Martín-Loeches, P. Nadarajan, C. Bannan, P. Mallon, G. Curley, R. Preston, A. Rehill, R. Baker, C. Ní Cheallaigh, J. O’Donnell   +22 more
semanticscholar   +1 more source

The role of VWF/FVIII in thrombosis and cancer progression in multiple myeloma and other hematological malignancies

Journal of Thrombosis and Haemostasis, 2022
Cancer associated thrombosis (CAT) is associated with significant morbidity and mortality, highlighting an unmet clinical need to improve understanding of the pathophysiology of CAT.
C. Comerford, S. Glavey, J. Quinn, J. O’Sullivan   +3 more
semanticscholar   +1 more source

ADAMTS13 regulation of VWF multimer distribution in severe COVID‐19

Journal of Thrombosis and Haemostasis, 2021
Consistent with fulminant endothelial cell activation, elevated plasma von Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19.
S. Ward, H. Fogarty, E. Karampini, M. Lavin, S. Schneppenheim, R. Dittmer, Hannah Morrin, S. Glavey, C. Ní Cheallaigh, C. Bergin, I. Martín-Loeches, P. Mallon, G. Curley, R. Baker, U. Budde, J. O’Sullivan, J. O. O' Donnell   +16 more
semanticscholar   +1 more source

Prognostic value of von Willebrand factor in clinical practice

Акушерство, гинекология и репродукция, 2022
The von Willebrand factor (vWF) is a multimeric plasma glycoprotein, which quantification has important prognostic value. The current literature review demonstrates a relationship between the disease severity and vWF level.
K. N. Grigoreva, V. O. Bitsadze, J. Kh. Khizroeva, V. I. Tsibizova, M. V. Tretyakova, D. V. Blinov, L. L. Pankratyeva, N. R. Gashimova, F. E. Yakubova, A. S. Antonova, J.-C. Gris, I. Elalamy, A. D. Makatsariya   +12 more
doaj   +1 more source

Immunothrombosis in cancer patients: contribution of neutrophil extracellular traps, ADAMTS-13 and von Willebrand factor

Акушерство, гинекология и репродукция, 2023
Introduction. Neutrophil extracellular traps (NETs) and von Willebrand factor (vWF) are integral players in thrombosis and inflammation in cancer patients. It has been increasingly evident that an active interplay exists between NETs and vWF.
E. V. Slukhanchuk, V. O. Bitsadze, A. G. Solopova, J. Kh. Khizroeva, V. I. Tsibizova, J.-K. Gris, I. Elalamy, D. V. Shcherbakov, L. L. Pankratyeva, L. A. Ashrafyan, A. D. Makatsariya   +10 more
doaj   +1 more source

Decreasing VWF-levels upon NSBB-therapy indicate a decreased risk of further decompensation, ACLF, and death.

Clinical Gastroenterology and Hepatology, 2021
BACKGROUND&AIMS Non-selective betablockers (NSBB) exert beneficial effects beyond lowering hepatic venous pressure gradient (HVPG), which may be particularly relevant in patients with decompensated cirrhosis (DC), in whom bacterial translocation and ...
M. Jachs, L. Hartl, B. Simbrunner, D. Bauer, R. Paternostro, B. Scheiner, P. Schwabl, A. Stättermayer, M. Pinter, E. Eigenbauer, P. Quehenberger, M. Trauner, T. Reiberger, M. Mandorfer   +13 more
semanticscholar   +1 more source

VWF, Platelets and the Antiphospholipid Syndrome

International Journal of Molecular Sciences, 2021
The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity with the persistent presence of antiphospholipid antibodies (aPLs).
Shengshi Huang, M. Ninivaggi, W. Chayoua, B. de Laat   +3 more
semanticscholar   +1 more source

Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update

Platelets, 2023
ADAMTS13 is a plasma metalloprotease with the primary function of cleaving VWF to maintain hemostasis. Circulating ADAMTS13 is in the closed conformation until blood vessel injury triggers a VWF-dependant activation to the open active form of the protein.
Zoe Markham-Lee, Neil V. Morgan, Jonas Emsley   +2 more
doaj   +1 more source

Microlyse; a thrombolytic agent that targets VWF for clearance of microvascular thrombosis.

Blood, 2021
Thrombotic microangiopathies are hallmarked by attacks of disseminated microvascular thrombosis. In thrombotic thrombocytopenic purpura (TTP), this is caused by a rise in thrombogenic ultra-large von Willebrand factor (VWF) multimers because of ADAMTS13 ...
S. de Maat, C. Clark, A. Barendrecht, Simone Smits, Nadine D. van Kleef, H. El Otmani, M. Waning, M. V. van Moorsel, M. Szardenings, N. Delaroque, Kristof Vercruysse, R. Urbanus, Silvie A. E. Sebastian, P. Lenting, C. Hagemeyer, T. Renné, K. Vanhoorelbeke, C. Tersteeg, C. Maas   +18 more
semanticscholar   +1 more source