A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9
Research and Practice in Thrombosis and Haemostasis, 2020 Background Von Willebrand Disease (VWD) is the most common inherited bleeding disorder, caused by quantitative and qualitative changes in von Willebrand factor (VWF).
Jessica Garcia +9 more
doaj +1 more source
Identification and functional analysis of a novel von Willebrand factor mutation in a family with type 2A von Willebrand disease. [PDF]
PLoS ONE, 2012 von Willebrand factor (VWF) is essential for normal hemostasis. VWF gene mutations cause the hemorrhagic von Willebrand disease (VWD). In this study, a 9-year-old boy was diagnosed as type 2A VWD, based on a history of abnormal bleeding, low plasma VWF ...
Jing Dong +7 more
doaj +1 more source
Angiogenesis and the ADAMTS13-VWF balance [PDF]
Blood, 2017 In this issue of Blood , Xu et al describe a new function for the metalloprotease ADAMTS13 in blood vessel formation following brain ischemia. Using multiple approaches in mice, they show that ADAMTS13 is required for neovascularization and vascular repair following ischemic stroke.
openaire +2 more sources
Isolation of equine endothelial cells and life cell angiogenesis assay [PDF]
, 2014 Arterial or venous thromboses are frequent clinical complications with the risk of fatal progression. Recent studies suggest the disruption of angiogenesis in the course of thrombus resolution as the underlying pathomechanism.
Dietze, Kathrin +5 more
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A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13. [PDF]
PLoS ONE, 2011 The size of von Willebrand factor (VWF), controlled by ADAMTS13-dependent proteolysis, is associated with its hemostatic activity. Many factors regulate ADAMTS13-dependent VWF proteolysis through their interaction with VWF.
Jingyu Zhang +8 more
doaj +1 more source
Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]
, 2014 Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright +17 more
core +1 more source
Clinical and Applied Thrombosis/Hemostasis, 2020 von Willebrand factor (VWF) acts as a bridge between platelets and the subendothelial matrix following vessel damage and plays a vital role in coronary artery disease (CAD).
Bin Yan MS +8 more
doaj +1 more source
Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. [PDF]
, 2005 Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Ashton, SV +6 more
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Frequency weightings of hand-transmitted vibration for predicting vibration-induced white finger
Scandinavian Journal of Work, Environment & Health, 2011 OBJECTIVE: The aim of this study was to investigate the performance of four frequency weightings for hand-transmitted vibration to predict the incidence of vibration-induced white finger (VWF).
Massimo Bovenzi +4 more
doaj +1 more source
High Glucose, But Not Testosterone, Increases Platelet Aggregation Mediated by Endothelial Cells [PDF]
, 2015 Endothelial cells inhibit platelet aggregation by releasing thromboregulators, such as prostacyclin and nitric oxide. Male subject is a traditional risk factor for cardiovascular diseases.
Aswin, S. (Soedjono) +3 more
core +2 more sources