Results 31 to 40 of about 104,334 (371)

The development and characterization of a long acting anti‐thrombotic von Willebrand factor (VWF) aptamer

open access: yesJournal of Thrombosis and Haemostasis, 2020
Thrombus formation involves coagulation proteins and platelets. The latter, referred to as platelet‐mediated thrombogenesis, is predominant in arterial circulation. Platelet thrombogenesis follows vascular injury when extracellular von Willebrand factor (
Shuhao Zhu   +7 more
semanticscholar   +1 more source

Von Willebrand Disease [PDF]

open access: yes, 2017
Von Willebrand Disease (VWD) is a blood clotting disorder characterized by low levels of the Von Willebrand Factor (VWF) in the blood. VWF is functions to bind platelets and promote clotting of the blood when vascular injury occurs.
Misla David, Ramon
core   +2 more sources

Simulation of thrombosis in a stenotic microchannel: The effects of vWF-enhanced shear activation of platelets.

open access: yesInternational Journal of Engineering Science, 2020
This study was undertaken to develop a numerical/computational simulation of von Willebrand Factor (vWF) - mediated platelet shear activation and deposition in an idealized stenosis.
Wei‐Tao Wu   +4 more
semanticscholar   +1 more source

Neutrophil extracellular traps: a role in inflammation and dysregulated hemostasis as well as in patients with COVID-19 and severe obstetric pathology

open access: yesАкушерство, гинекология и репродукция, 2021
Numerous studies have proven a close relationship between inflammatory diseases and the state of hypercoagulability. In fact, thromboembolic complications represent one of the main causes of disability and mortality in acute and chronic inflammatory ...
A. D. Makatsariya   +14 more
doaj   +1 more source

Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]

open access: yes, 2017
NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina   +8 more
core   +1 more source

Low VWF levels in children and lack of association with bleeding in children undergoing tonsillectomy.

open access: yesBlood Advances, 2020
von Willebrand disease is a common bleeding disorder, but diagnosis can be difficult in young children who have not had bleeding challenges. We sought to evaluate the correlation between bleeding and von Willebrand factor (VWF) levels in children ...
J. Gill   +11 more
semanticscholar   +1 more source

Global Thrombosis Test - a possible monitoring system for the effects and safety of dabigatran [PDF]

open access: yes, 2015
© Otsui et al. 2015BACKGROUND: Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage of dabigatran over WF is that monitoring is not required; however, a
Gorog, Diana A   +8 more
core   +2 more sources

Low VWF: insights into pathogenesis, diagnosis, and clinical management.

open access: yesBlood Advances, 2020
von Willebrand disease (VWD) constitutes the most common inherited human bleeding disorder. Partial quantitative von Willebrand factor (VWF) deficiency is responsible for the majority of VWD cases.
J. O’Donnell
semanticscholar   +1 more source

Application of microfluidic devices in studies of thrombosis and hemostasis

open access: yesPlatelets, 2017
Due to the importance of fluid flow during thrombotic episodes, it is quite appropriate to study clotting and bleeding processes in devices that have well-defined fluid shear environments.
Changjie Zhang, Sriram Neelamegham
doaj   +1 more source

Levels of von Willebrand factor antigen and von Willebrand factor cleaving protease (ADAMTS13) activity predict clinical events in chronic heart failure. [PDF]

open access: yes, 2009
Decreased activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease, was recently reported in cardiovascular diseases and in hepatic failure.
Borgulya, Gábor   +10 more
core   +1 more source

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