Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]
, 2014 Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright +17 more
core +1 more source
Complex changes in von Willebrand factor-associated parameters are acquired during uncomplicated pregnancy. [PDF]
PLoS ONE, 2014 BACKGROUND:The coagulation protein von Willebrand Factor (VWF) is known to be elevated in pregnancy. However, the timing and nature of changes in VWF and associated parameters throughout pregnancy are not well understood.
Danielle N Drury-Stewart +7 more
doaj +1 more source
, 2014 A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core +1 more source
Frequency weightings of hand-transmitted vibration for predicting vibration-induced white finger
Scandinavian Journal of Work, Environment & Health, 2011 OBJECTIVE: The aim of this study was to investigate the performance of four frequency weightings for hand-transmitted vibration to predict the incidence of vibration-induced white finger (VWF).
Massimo Bovenzi +4 more
doaj +1 more source
Reciprocal interactions between tumor and endothelial cells: Effects of selective vasopressin V2 receptor peptide agonists [PDF]
, 2014 Recent experimental evidence suggested that the synthetic peptide desmopressin (DDAVP) interferes tumor angiogenesis by inducing the formation of angiostatin.
Alonso, Daniel Fernando, Garona, Juan
core +1 more source
TH Open, 2017 Background Inflammatory bowel disease (IBD) affects 1.6 million people in the United States. IBD is associated with an increased risk of thrombosis, which rises with disease activity.
Naamah L. Zitomersky +7 more
doaj +1 more source
A conformation-sensitive monoclonal antibody against the A2 domain of von Willebrand factor reduces its proteolysis by ADAMTS13. [PDF]
PLoS ONE, 2011 The size of von Willebrand factor (VWF), controlled by ADAMTS13-dependent proteolysis, is associated with its hemostatic activity. Many factors regulate ADAMTS13-dependent VWF proteolysis through their interaction with VWF.
Jingyu Zhang +8 more
doaj +1 more source
Wind field and sex constrain the flight speeds of central-place foraging albatrosses [PDF]
, 2009 By extracting energy from the highly dynamic wind and wave fields that typify pelagic habitats, albatrosses are able to proceed almost exclusively by gliding flight.
Akira Fukuda +12 more
core +1 more source
Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene
Blood, 2006 Abstract Both genetic and environmental influences contribute to the wide variation in plasma von Willebrand factor (VWF) levels observed in humans. Inbred mouse strains also have highly variable plasma VWF levels, providing a convenient model in which to study genetic modifiers of VWF.
Heidi L, Lemmerhirt +5 more
openaire +3 more sources
Two novel monoclonal antibodies to VWFA3 inhibit VWF‐collagen and VWF‐platelet interactions [PDF]
Journal of Thrombosis and Haemostasis, 2007 The interaction of collagen-von Willebrand factor (VWF)-GPIb is essential for platelet adhesion, especially under high shear conditions. VWF, which acts as a bridge between platelets and exposed subendothelium, interacts with collagen through its A3 domain, which is a new target for the antithrombotic agent.To develop functional blockers that ...
Y, Zhao +6 more
openaire +2 more sources