Results 61 to 70 of about 81,482 (329)

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 [PDF]

, 2018
Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is ...
A Clayton, A Desmouliere, A Holmes, A Yabuki, AA Eddy, AA Eddy, AC Sanchez-Lara, BL Aken, C Grupp, C. P. D. Wheeler-Jones, CH Heldin, CL Marino, E Honda, E Van Obberghen-Schilling, F Strutz, F Strutz, F Syeda, GR Grotendorst, H. M. Syme, HP Rodemann, J Ivaska, J Lu, J. Elliott, J. S. Lawson, JL Mumaw, JS Lawson, K Sawashima, KG McCullagh, KJ Kelynack, LC Penning, M Prunotto, M Zeisberg, MA Venkatachalam, MJ Ryan, MK Phanish, ML Sequeira Lopez, P Boor, P Sysa, PC Bartlett, Q Chai, RA Ignotz, S Chakrabarti, S Meran, S Moll, S Neelisetty, SC Chen, SL Lin, SP DiBartola, SW Smith, T Akamatsu, TA Wynn, V Dugina, VS Lebleu, W Bloom, WA Border, X Pan, XM Meng, Y Hosokawa, Y Liu   +58 more
core   +2 more sources

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

VWF fibers induce thrombosis during cancer [PDF]

Blood, 2015
In this issue of Blood, Bauer et al1 provide an explanation for the formation of luminal von Willebrand factor (VWF) fibers observed in cancer patients, which is initiated through tumor-derived vascular endothelial growth factor-A (VEGF-A). Platelet aggregation on VWF fibers correlated with a prothrombic state associated with decreased a disintegrin ...
openaire   +3 more sources

Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men. [PDF]

, 2014
OBJECTIVES: To examine associations between sarcopenia, obesity, and sarcopenic obesity and risk of cardiovascular disease (CVD) and all-cause mortality in older men. DESIGN: Prospective cohort study.
Atkins, JL, Lennon, LT, Morris, RW, Papacosta, O, Wannamethee, SG, Whincup, PH   +5 more
core   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Revision of Madagascar's Dwarf Lemurs (Cheirogaleidae:Cheirogaleus): Designation of Species, Candidate Species Status and Geographic Boundaries Based on Molecular and Morphological Data [PDF]

, 2014
The genus Cheirogaleus, the dwarf lemurs, is a radiation of strepsirrhine primates endemic to the island of Madagascar. The dwarf lemurs are taxonomically grouped in the family Cheirogaleidae (Infraorder: Lemuriformes) along with the genera Microcebus,
Bailey, Carolyn A, Engberg, Shannon E, Frasier, Cynthia L., Ginter, Azure L, Groves, Colin P., Lei, Runhua, Louis, Jr Edward E., McLain, Adam, Mittermeier, Russell A., Randriamampionona, Richard, Taylor, Justin M   +10 more
core   +1 more source

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu, Xuefei Liu, Liwen Gu, Jingru Lian, Yuting Wang, Yixin Cheng, Lianhui Duan, Guanyin Huang, Siqi Chen, Boxi Zhao, Sailan Liu, Yufan Yang, Shuqian Zheng, Zijian Lu, Wanping Guo, Jianyang Hu, Wenjing Wang, Zhixiang Zuo, Haiqiang Mai, LinQuan Tang, Songfa Zhang, Feiqiu Wen, Xin Hong, Ling Guo   +23 more
wiley   +1 more source

Lower levels of vWF are associated with lower risk of cardiovascular disease

Research and Practice in Thrombosis and Haemostasis, 2022
Objective The current study was undertaken to prospectively explore whether having low levels of von Willebrand factor (vWF) antigen and vWF activity reduce the risk for cardiovascular disease and death. Methods VWF antigen and vWF activity were measured
Pauline C. S. vanParidon, Marina Panova‐Noeva, Rene vanOerle, Andreas Schulz, Jürgen H. Prochaska, Natalie Arnold, Irene Schmidtmann, Manfred Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J. Lackner, Hugo tenCate, Philipp S. Wild, Henri M. H. Spronk   +13 more
doaj   +1 more source

Close relation of arterial ICC-like cells to the contractile phenotype of vascular smooth muscle cell [PDF]

, 2007
This work aimed to establish the lineage of cells similar to the interstitial cells of Cajal (ICC), the arterial ICC-like (AIL) cells, which have recently been described in resistance arteries, and to study their location in the artery wall.
Bolton, TB, Gordienko, DV, Harhun, MI, Moss, RF, Povstyan, OV, Pucovský, V   +5 more
core   +3 more sources