Results 21 to 30 of about 678,174 (319)
100 years of the Warburg effect:a historical perspective [PDF]
, 2022 Otto Warburg published the first paper describing what became known as the Warburg effect in 1923. All that was known about glucose metabolism at that time was that it occurred in two stages: (i) fermentation (glycolysis) in which glucose was converted ...
Hardie, Grahame
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The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer:Targets for Effective Therapy with 3-Bromopyruvate [PDF]
, 2016 This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the “Warburg” and “Crabtree” effects.
Andre Goffeau +32 more
core +6 more sources
The Warburg effect and drug resistance [PDF]
British Journal of Pharmacology, 2016 The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently,
Richie Soong +2 more
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The Warburg Effect Is Genetically Determined in Inherited Pheochromocytomas [PDF]
, 2009 The Warburg effect describes how cancer cells down-regulate their aerobic respiration and preferentially use glycolysis to generate energy. To evaluate the link between hypoxia and Warburg effect, we studied mitochondrial electron transport, angiogenesis
A King +59 more
core +12 more sources
The epigenetic basis of the Warburg effect [PDF]
Epigenetics, 2010 Cancer development results from the accumulation of genetic and epigenetic changes. By interacting with intracellular signaling to promote carcinogenesis, epigenetic networks can actively transform cancer-promoting signals from tumor-permissive microenvironment to coordinate cellular proliferation and metabolism in the initiation and progression of ...
Hongchuan Jin, Xian Wang
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The Alkaline Diet and the Warburg Effect
World Nutrition, 2021 The changing diets accompanying our modern life style have increased the content of foods that form acidic metabolic waste residues in the body. Wastes from these metabolic processes are released into the interstitial fluids and the blood, slightly changing their pH temporarily.
Hassan Bahrami, Ted Greiner
openaire +4 more sources
The Warburg effect and its role in cancer detection and therapy [PDF]
, 2009 The Warburg effect is a cellular phenomenon in cancer cells discovered by Otto Warburg in 1924. His findings showed that in normoxic conditions tumor cells primarily use glycolysis for energy production instead of mitochondrial oxidative phosphorylation ...
Christ, Ethan J.
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Cellular Physiology and Biochemistry, 2017 Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological component in pulmonary arterial hypertension (PAH).
Yunbin Xiao +9 more
doaj +1 more source
Fractality in tumor growth at the avascular stage from a generalization of the logistic-Gompertz dynamics [PDF]
, 2022 The dynamics between healthy and malignant cells at the avascular stage of growth is described by a set of chemical reactions representing the populations of both types of cells. We obtain a generalization of the logistic-Gompertz dynamics and study the consequences in terms of the properties of tumor growth associated with the Warburg effect, mitosis ...
arxiv +1 more source
PARP14 promotes the warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation [PDF]
, 2015 Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link the Warburg effect with the suppression of apoptosis are not well understood.
A Barbarulo +61 more
core +2 more sources