Results 21 to 30 of about 13,460,861 (391)
The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer:Targets for Effective Therapy with 3-Bromopyruvate [PDF]
, 2016 This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the “Warburg” and “Crabtree” effects.
Andre Goffeau +32 more
core +7 more sources
The Warburg effect modulates DHODH role in ferroptosis: a review
Cell Communication and Signaling, 2023 Ferroptosis is an iron-dependent regulated cell death that suppresses tumor growth. It is activated by extensive peroxidation of membrane phospholipids caused by oxidative stress.
Alvan Amos, A. Amos, Li-rong Wu, H. Xia
semanticscholar +1 more source
Synaptic Plasticity and the Warburg Effect [PDF]
Cell Metabolism, 2014 Functional brain imaging studies show that in certain brain regions glucose utilization exceeds oxygen consumption, indicating the predominance of aerobic glycolysis. In this issue, Goyal et al. (2014) report that this metabolic profile is associated with an enrichment in the expression of genes involved in synaptic plasticity and remodeling processes.
Pierre J. Magistretti +2 more
openaire +4 more sources
The Warburg effect: 80 years on [PDF]
Biochemical Society Transactions, 2016 Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells' energy generation is different from that of normal cells. They observed high glucose consumption and large amounts of lactate excretion from cancer cells compared with normal cells, which oxidised glucose using mitochondria.
Morten, K, Potter, M, Newport, E
openaire +4 more sources
Frontiers in Pharmacology, 2021 Atrial fibrosis is the basis for the occurrence and development of atrial fibrillation (AF) and is closely related to the Warburg effect, endoplasmic reticulum stress (ERS) and mitochondrion dysfunctions-induced cardiomyocyte apoptosis. Hydrogen sulfide (
Heng-Jing Hu +12 more
doaj +1 more source
Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer
The Journal of Pathology: Clinical Research, 2022 Previous research has suggested that the expression of proteins related to the Warburg effect may have prognostic value in colorectal cancer (CRC), but results remain inconsistent.
Kelly Offermans +9 more
doaj +1 more source
The Warburg effect and drug resistance [PDF]
British Journal of Pharmacology, 2016 The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently,
Richie Soong +2 more
openaire +3 more sources
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?
Aging and Disease, 2023 Metabolic reprogramming is a defining hallmark of cancer metastasis, warranting thorough exploration. The tumor-promoting function of the "Warburg Effect", marked by escalated glycolysis and restrained mitochondrial activity, is widely acknowledged. Yet,
Zhuofeng Jiang +11 more
semanticscholar +1 more source
The Alkaline Diet and the Warburg Effect
World Nutrition, 2021 The changing diets accompanying our modern life style have increased the content of foods that form acidic metabolic waste residues in the body. Wastes from these metabolic processes are released into the interstitial fluids and the blood, slightly changing their pH temporarily.
Hassan Bahrami, Ted Greiner
openaire +4 more sources
Cellular Physiology and Biochemistry, 2017 Background/Aims: The enhanced proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a central pathological component in pulmonary arterial hypertension (PAH).
Yunbin Xiao +9 more
doaj +1 more source