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The effect of <i>Withania somnifera</i> (Ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis. [PDF]

BJPsych Open
Marchi M, Grenzi P, Travascio A, Uberti D, De Micheli E, Quartaroli F, Laquatra G, Pingani L, Ferrari S, Galeazzi GM.   +9 more
europepmc   +1 more source

Withanolides from Withania somnifera roots

Phytochemistry, 2008
Two new and seven known withanolides along with beta-sitosterol, stigmasterol, beta-sitosterol glucoside, stigmasterol glucoside, alpha+beta glucose were isolated from the roots of Withania somnifera. Among the known compounds, Viscosa lactone B, stigmasterol, stigmasterol glucoside and alpha+beta glucose are being reported from the roots of W ...
Laxminarain Misra, Priyanka Mishra, Rajender S Sangwan   +2 more
exaly   +4 more sources

Cytotoxic withanolides from Acnistus arborescens

Phytochemistry, 2002
Three cytotoxic withanolides, two with new structures, were isolated from the leaves of Acnistus arborescens and their structures determined by a combination of 1D and 2D NMR, mass spectral, and molecular modeling studies. Dereplication analysis of the ethyl ether extract was useful for evaluating the components showing significant cytotoxic activity.
Sandro, Minguzzi, Lauro E S, Barata, Young Geun, Shin, Patrick F, Jonas, Hee Byung, Chai, Eun Jung, Park, John M, Pezzuto, Geoffrey A, Cordell   +7 more
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Biosynthesis of the triterpenoid withanolides in Withania somnifera

Current Opinion in Plant Biology
Ashwagandha (Withania somnifera L. Dunal) is a versatile medicinal plant of Solanaceae family, renowned for its potent therapeutic properties, due to which it is extensively used in Indian traditional systems of medicine such as Ayurveda. The medicinal properties are attributed to specialized metabolites known as withanolides, which are chemically ...
Ananth Krishna Narayanan, Dinesh A Nagegowda   +1 more
exaly   +3 more sources

Withanolides from Withania adpressa

Helvetica Chimica Acta, 2007
AbstractFrom the leaves of Withania adpressa, a plant endemic to Sahara of Morocco and Algeria, the novel steroidal lactone (22R)‐14α,15α,17β,20β‐tetrahydroxy‐1‐oxowitha‐2,5,24‐trien‐26,22‐olide (= (15S,17S)‐14,15,17,20‐tetrahydroxy‐22,26‐epoxyergosta‐2,5,24‐triene‐1,26‐dione; 1), was isolated, along with three known compounds, withanolides F (2), J (3)
Abdeljebbara, Lalla Hasna, Humam, Munir, Christen, Philippe, Jeannerat, Damien, Vitorge, Bruno, Amzazi, Saaid, Benjouad, Abdelaziz, Hostettmann, Kurt, Bekkoucheb, Khalid   +8 more
openaire   +3 more sources

Natural withanolides, an update

Natural Product Reports, 2022
This review summarizes the research progress on the structural classification, biological activities and mechanisms, metabolism and pharmacokinetic investigations, biosynthesis, and synthesis and structural modifications of the withanolides.
Gui-yang Xia, Shi-jie Cao, Li-xia Chen, Feng Qiu   +3 more
openaire   +2 more sources

Withanolides from Discopodium penninervium

Fitoterapia, 2023
Discopodium penninervium is a medicinal plant endemic to Ethiopia. Its twigs extract led to the isolation of three new withanolides, discopodinolides A - C, and four known analogues. The structures of the compounds were elucidated using NMR, HRMS data analyses, and literature data.
Kibrom Gebreheiwot, Bedane, Mekonnen Abebayehu, Desta, Peter, Spiteller   +2 more
openaire   +2 more sources

Natural withanolides: an overview

Natural Product Reports, 2011
Withanolides are a group of naturally occurring C28 steroids built on an ergostane skeleton functionalized at carbons 1, 22 and 26, commonly known as the withanolide skeleton. Over the period of August 1996 to March 2010, 360 new naturally occurring withanolides were isolated and identified.
Li-Xia, Chen, Hao, He, Feng, Qiu
openaire   +2 more sources