Results 1 to 10 of about 315,076 (198)
Wnt signaling and cancer [PDF]
Genes & Development, 2000 The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately
Paul Polakis
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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
Signal Transduction and Targeted Therapy, 2022 The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer
Jiaqi Liu +8 more
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Frontiers in Physiology, 2021 Exercise initiates systemic adaptation to promote health and prevent various lifestyle-related chronic diseases. Emerging evidence suggests that circulating exosomes mediate some of the beneficial effects of exercise via the transfer of microRNAs between
Kitti Garai +13 more
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Rab7 is required for mesoderm patterning and gastrulation in Xenopus
Biology Open, 2021 Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling. Modulations are achieved at multiple levels, from cellular transcription to tissue-scale behavior.
Jennifer Kreis +2 more
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Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer [PDF]
Iranian Journal of Colorectal Research, 2020 : 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions.
Morvarid Siri +3 more
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eLife, 2021 Neuronal cell fate determinants establish the identities of neurons by controlling gene expression to regulate neuronal morphology and synaptic connectivity.
Mizuki Kurashina +5 more
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Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
Molecular Cancer, 2022 Background The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer, but is also involved in normal physiological processes in adults.
Hui-Ying Zhao +7 more
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The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators.
Annual Review of Biochemistry, 2022 The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the ...
E. Y. Rim, H. Clevers, R. Nusse
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Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer
Cell Death and Differentiation, 2022 The development of chemotherapy resistance is the most vital obstacle to clinical efficacy in gastric cancer (GC). The dysregulation of the Wnt/beta-catenin signaling pathway is critically associated with GC development and chemotherapy resistance ...
Yue Wang +14 more
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The amyloid precursor protein is a conserved Wnt receptor
eLife, 2021 The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown.
Tengyuan Liu +11 more
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