Results 11 to 20 of about 423,254 (279)

When Wnts antagonize Wnts [PDF]

The Journal of Cell Biology, 2003
Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that “noncanonical” Wnt signaling inhibits the “canonical” Wnt/β-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of β-catenin ...
Weidinger, Gilbert, Moon, Randall T.
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Wnt Proteins [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Karl, Willert, Roel, Nusse
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Wnt and Wnt inhibitors in bone metastasis [PDF]

BoneKEy Reports, 2012
Bone metastasis is a clinically devastating development of progressive cancers including prostate carcinoma, breast carcinoma and multiple myeloma. Bone metastases are typically painful, lead to adverse skeletal-related events, such as fracture, and are highly resistant to therapy.
Joseph L, Sottnik, Christopher L, Hall, Jian, Zhang, Evan T, Keller   +3 more
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Winning WNT: Race to Wnt signaling inhibitors [PDF]

Proceedings of the National Academy of Sciences, 2011
More than a quarter of a century ago, a mammalian homolog of Drosophila wingless, int-1 (Wnt1), was identified as an oncogenic viral integration site in mouse breast cancer (1). A decade later, deregulation of canonical Wnt/β-catenin signaling through mutations in adenomatous polyposis coli (APC) was recognized to be an initiating event in colon ...
Kazuhide, Watanabe, Xing, Dai
openaire   +2 more sources

Artificial Neural Network Correlation and Biostatistics Evaluation of Physiological and Molecular Parameters in Healthy Young Individuals Performing Regular Exercise

Frontiers in Physiology, 2019
Studies support that regular physical activity (PA) decelerates senescence-related decline of physiological and molecular parameters in the elderly. We have addressed the other end of this spectrum: healthy and young, inactive individuals participated in
Kitti Garai, Kitti Garai, Zoltan Adam, Zoltan Adam, Robert Herczeg, Emese Katai, Emese Katai, Tamas Nagy, Tamas Nagy, Szilard Pal, Attila Gyenesei, Judit E. Pongracz, Judit E. Pongracz, Marta Wilhelm, Krisztian Kvell, Krisztian Kvell   +15 more
doaj   +1 more source

Quantitative analysis of signaling responses during mouse primordial germ cell specification

Biology Open, 2021
During early mammalian development, the pluripotent cells of the embryo are exposed to a combination of signals that drive exit from pluripotency and germ layer differentiation.
Sophie M. Morgani, Anna-Katerina Hadjantonakis   +1 more
doaj   +1 more source

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. [PDF]

, 2012
The pluripotent nature of human embryonic stem cells (hESCs) makes them convenient for deriving therapeutically relevant cells. Here we show using Wnt reporter hESC lines that the cells are heterogeneous with respect to endogenous Wnt signalling activity.
Ardehali, Reza, Blauwkamp, Timothy A, Nigam, Shelly, Nusse, Roel, Weissman, Irving L   +4 more
core   +1 more source

miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation

Cells, 2020
During the development of the central nervous system, the proliferation of neural progenitors and differentiation of neurons and glia are tightly regulated by different transcription factors and signaling cascades, such as the Wnt and Shh pathways.
Lavanya Adusumilli, Nicola Facchinello, Cathleen Teh, Giorgia Busolin, Minh TN Le, Henry Yang, Giorgia Beffagna, Stefano Campanaro, Wai Leong Tam, Francesco Argenton, Bing Lim, Vladimir Korzh, Natascia Tiso   +12 more
doaj   +1 more source

Upregulated wnt-11 and mir-21 expression trigger epithelial mesenchymal transition in aggressive prostate cancer cells [PDF]

, 2020
Prostate cancer (PCa) is the second-leading cause of cancer-related death among men. microRNAs have been identified as having potential roles in tumorigenesis.
Arisan, E.D., Arisan, E.D., Freitas, I.L., Freitas, I.L., Keskin, B., Keskin, B., Kothari, A., Kothari, A., Radzali, S., Radzali, S., Rencuzogullari, O., Rencuzogullari, O., Uysal-Onganer, P., Uysal-Onganer, P., Warford, A., Warford, A.   +15 more
core   +1 more source

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation [PDF]

, 2013
A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT ...
A Gregorieff, A Horii, A Jung, A Novak, AC de Vries, AN Milne, AT Franco, B Kim, B Tycko, C Cavard, D Athineos, D M Pritchard, DM Parkin, E Half, E Tahara, EF Chan, G Gatta, H Guillen-Ahlers, H Ireland, H Luche, H Nagase, H Oshima, H Shibata, H Watanabe, H Zhang, HC Zheng, HJ Freeman, J Cordero, J Neumann, J Parsonnet, J Woodgett, JG Forte, K Miyazawa, K Oien, KF Becker, KW Kinzler, LK Bianchi, M Crabtree, M Iida, M Nakayama, M Shitashige, M Suzuki, M Suzuki, M Torbenson, MG Smith, MP Ebert, N Barker, N Barker, N Barker, N Barker, N Barker, N Harada, N Murata-Kamiya, N Uemura, O J Sansom, O Sokolova, O Tetsu, OJ Sansom, P Blache, P Correa, P Correa, P Lauren, P Salgueiro, P Soriano, PJ Guilford, R A Ridgway, R Kemp, R Poulsom, S Garrean, S Nakatsuru, S Patel, S Patel, S Radulescu, S Segditsas, S Sekine, SC Abraham, SC Abraham, SM Przemeck, SS Ng, T Gnad, T Oda, TC He, WM Clements, WS Park, XC He, Y Miyoshi, Y Park do, Z Spicer, Z Zhao   +88 more
core   +1 more source