Results 31 to 40 of about 315,126 (245)
Targeting the Wnt/β-catenin signaling pathway in cancer
Journal of Hematology & Oncology, 2020 The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy response.
Ya Zhang, Xin Wang
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WNT as a Driver and Dependency in Cancer.
Cancer Discovery, 2021 The WNT signaling pathway is a critical regulator of development and adult tissue homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of WNT signaling is common, the type and frequency of genetic WNT pathway alterations ...
Marie J Parsons, T. Tammela, L. Dow
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Winning WNT: Race to Wnt signaling inhibitors [PDF]
Proceedings of the National Academy of Sciences, 2011 More than a quarter of a century ago, a mammalian homolog of Drosophila wingless, int-1 (Wnt1), was identified as an oncogenic viral integration site in mouse breast cancer (1). A decade later, deregulation of canonical Wnt/β-catenin signaling through mutations in adenomatous polyposis coli (APC) was recognized to be an initiating event in colon ...
Xing Dai, Kazuhide Watanabe
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Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway
Frontiers in Pharmacology, 2021 Idiopathic pulmonary fibrosis is a progressive lung disease with high mortality and limited therapy that is characterized by epithelial cell damage and fibroblast activation.
Xiaohe Li +26 more
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Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
Molecular Cancer, 2020 Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling embryonic and organ development, as well as cancer progression.
Xiufang Xu +3 more
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Cold Spring Harbor Perspectives in Biology, 2012 Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a myriad of cell biological and developmental processes. Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been ...
Karl, Willert, Roel, Nusse
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Experimental and Molecular Medicine, 2020 Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt ...
Youn-Sang Jung, Jae-Il Park
semanticscholar +1 more source
Cells, 2019 : AF1q impairs survival in hematologic and solid malignancies. AF1q expression is associated with tumor progression, migration, and chemoresistance, and acts as a transcriptional co-activator in WNT and STAT signaling.
Elisabeth S. Gruber +10 more
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Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis
Cells, 2019 Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Yu Ji +4 more
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WNT Signaling in Neuroblastoma [PDF]
Cancers, 2019 The term WNT (wingless-type MMTV integration site family) signaling comprises a complex molecular pathway consisting of ligands, receptors, coreceptors, signal transducers and transcriptional modulators with crucial functions during embryonic development, including all aspects of proliferation, morphogenesis and differentiation.
Becker, Juergen, Wilting, Joerg
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