Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation [PDF]
, 2013 A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT ...
A Gregorieff +88 more
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Cells, 2019 : AF1q impairs survival in hematologic and solid malignancies. AF1q expression is associated with tumor progression, migration, and chemoresistance, and acts as a transcriptional co-activator in WNT and STAT signaling.
Elisabeth S. Gruber +10 more
doaj +1 more source
Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled [PDF]
Open Biology, 2015 Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity and other non-nuclear events in post-mitotic cells.
Thomas Mund +5 more
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Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis
Frontiers in Immunology, 2022 Visceral leishmaniasis, caused by L. donovani infection is fatal if left untreated. The intrinsic complexity of visceral leishmaniasis complicated further by the increasing emergence of drug resistant L.
Shreyasi Maity +5 more
doaj +1 more source
Bionanotechnological strategies for the synthesis of quercetin conjugates with selenium nanoparticles for their targeting of the Wnt/Ca2+signaling pathway [PDF]
Технологія виробництва і переробки продуктів тваринництва, 2023 One of the applications of nanotechnology is the synthesis of nanoparticles for targeted drug delivery and disease prevention. In the agricultural sector, nanotechnology holds great promise for improving animal health and productivity.
Bityutskyy V.S. +5 more
doaj +1 more source
IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells. [PDF]
, 2016 In previous works, we have shown that insulin-like growth factor-binding protein-3 (IGFBP-3), a tissue and circulating protein able to bind to IGFs, decreases drastically in the blood serum of patients with diffuse metastatic melanoma.
Londei, Paola +7 more
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eLife, 2016 How cells in the embryo coordinate epithelial plasticity with cell fate decision in a fast changing cellular environment is largely unknown. In chick embryos, skeletal muscle formation is initiated by migrating Delta1-expressing neural crest cells that ...
Daniel Sieiro +3 more
doaj +1 more source
A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. [PDF]
, 2017 Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt ...
Aznar, Nicolas +5 more
core +3 more sources
Developmental Cell, 2003 AbstractA recent Juan March Foundation workshop on “wnt genes and Wnt signaling” brought developmental and cancer biologists together to share some of the latest advances in Wnt research. Discussion topics included molecular, genetic, and genomic dissections of wnt genes in embryogenesis and cancer, Wnt signaling components and downstream targets ...
openaire +1 more source
Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
core +1 more source