Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled [PDF]
Open Biology, 2015 Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent transcription to specify proliferative cell fates, and cell polarity and other non-nuclear events in post-mitotic cells.
Thomas Mund +5 more
doaj +1 more source
Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis [PDF]
, 2012 Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision.
A Poltorak +89 more
core +10 more sources
Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. [PDF]
, 2016 Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Benham-Pyle, Blair W +4 more
core +2 more sources
Rethinking WNT signalling [PDF]
Nature, 2018 The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of regulation for the WNT signalling pathway during limb development. The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of ...
Jessica A, Lehoczky, Clifford J, Tabin
openaire +2 more sources
Morphogenesis and axis specification occur in parallel during optic cup and optic fissure formation, differentially modulated by BMP and Wnt [PDF]
Open Biology, 2019 Optic cup morphogenesis is an intricate process. Especially, the formation of the optic fissure is not well understood. Persisting optic fissures, termed coloboma, are frequent causes for congenital blindness.
Priska Eckert +4 more
doaj +1 more source
Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]
, 2017 Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita +5 more
core +3 more sources
, 2019 The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S. +20 more
core +1 more source
Cell Research, 2011 Wnt signaling is a highly conserved and context-dependent signal transduction pathway that belongs to the so-called morphogens. Wnt signals are instrumental during development, but also play a central role in tissue homeostasis. For instance, in the intestine Wnt signaling is crucial for both stem cell maintenance and proliferation in the transient ...
de Sousa E Melo, Felipe +1 more
openaire +2 more sources
Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]
, 2012 Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson +79 more
core +1 more source
Cartilage development and degeneration: a Wnt Wnt situation [PDF]
Cell Biochemistry and Function, 2012 The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and ...
Katherine Ann, Staines +2 more
openaire +2 more sources