Results 51 to 60 of about 315,126 (245)
In the Wnt-er of life: Wnt signalling in melanoma and ageing [PDF]
British Journal of Cancer, 2016 Although the clinical landscape of melanoma is improving rapidly, metastatic melanoma remains a deadly disease. Age remains one of the greatest risk factors for melanoma, and patients older than 55 have a much poorer prognosis than younger individuals, even when the data are controlled for grade and stage.
Marie R. Webster +2 more
openaire +2 more sources
La vía Wnt/β-catenina disminuye la cantidad de osteoclastos en el hueso y favorece su apoptosis
Revista de Osteoporosis y Metabolismo Mineral, 2019 La activación de la señalización de Wnt/β-catenina en células del linaje osteoblástico conduce a un aumento en la masa ósea a través de un mecanismo dual: por una parte, aumentando la osteoblastogénesis, y por otra, disminuyendo la osteoclastogénesis. El
Martín-Millán M +5 more
doaj +1 more source
Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis
Frontiers in Immunology, 2022 Visceral leishmaniasis, caused by L. donovani infection is fatal if left untreated. The intrinsic complexity of visceral leishmaniasis complicated further by the increasing emergence of drug resistant L.
Shreyasi Maity +5 more
doaj +1 more source
Wnt Signaling in Mitosis [PDF]
Developmental Cell, 2009 Previously, the connection between cell proliferation and Wnt signaling focused on transcriptional activation of cyclin D1 and c-myc, which control the G1/S transition of the cell cycle. In this issue of Developmental Cell, the Niehrs group demonstrates mitotic activation of Wnt signaling by a novel Cdk/cyclin complex containing Cdk14 (PFTK1) and ...
Michele Pagano +2 more
openaire +3 more sources
Receptor and secreted targets of Wnt-1/β-catenin signalling in mouse mammary epithelial cells
BMC Cancer, 2005 Background Deregulation of the Wnt/ β-catenin signal transduction pathway has been implicated in the pathogenesis of tumours in the mammary gland, colon and other tissues.
Enver Tariq +2 more
doaj +1 more source
Quantitative analysis of signaling responses during mouse primordial germ cell specification
Biology Open, 2021 During early mammalian development, the pluripotent cells of the embryo are exposed to a combination of signals that drive exit from pluripotency and germ layer differentiation.
Sophie M. Morgani +1 more
doaj +1 more source
eLife, 2016 Wnt plays important role during development and in various diseases. Because Wnts are lipidated and highly hydrophobic, they can only be purified in the presence of detergents, limiting their use in various in vitro and in vivo assays.
Emiko Mihara +7 more
doaj +1 more source
Wnt signaling in development and tissue homeostasis
Development, 2018 The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis.
Z. Steinhart, S. Angers
semanticscholar +1 more source
Transcriptional Regulation of Wnt/β-Catenin Pathway in Colorectal Cancer
Cells, 2020 The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases and cancers, especially as a key driver in the initiation and progression of ...
Jia Bian +3 more
semanticscholar +1 more source
Wnt-1 and Wnt-4 regulate thymic cellularity [PDF]
European Journal of Immunology, 2002 Thymic primordium, formed by cells derived from the endoderm, the ectoderm and the neural crest-derived mesenchyme, receive fetal liver derived lymphoid precursors. Reciprocal cell-cell interactions between thymic stromal cells and lymphoid precursors are critical in the expansion and maturation of thymocytes. Transcription factor TCF-1 is critical for
Jill A. McMahon +4 more
openaire +3 more sources