Results 191 to 200 of about 65,785 (311)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

A SIMPLE METHOD TO DETERMINE INHIBITORY ACTIVITY OF XANTHINE OXIDASE IN VIVO

, 1982
Hisashi Miyazaki, Yoshimasa Matsunaga, Masahisa Hashimoto, Noriyuki Sunahara, Kanae Yokogawa   +4 more
openalex   +1 more source

A Phase 1 Open‐Label Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of a Single Intranasal Dose of Zavegepant in Healthy Chinese Adults

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Zavegepant is the only calcitonin gene‐related peptide antagonist approved as a nasal spray in the United States for acute treatment of migraine in adults with or without aura. This Phase 1, open‐label study evaluated the pharmacokinetics, safety, and tolerability of a single intranasal dose of zavegepant 10 mg in 12 healthy Chinese adults ...
Qiong Wei, Jufang Wu, Yangyi Dai, Jiaye Lin, Beikang Ge, Yanhui Sun, Jing Zhang, Jing Wang, Chen Li, Ding Ding, Jing Liu, Mohamed H. Shahin   +11 more
wiley   +1 more source

Beyond the Numbers: Reframing Uric Acid Elevations in Bempedoic Acid Therapy. [PDF]

JACC Adv
Fogacci F, Borghi C, Cicero AFG.
europepmc   +1 more source

Fish Oil Ameliorates Glycolipid Metabolism Disorders Induced by Long‐Term Potato Chip Diet Through Gut‐Liver Axis

Food Frontiers, Volume 7, Issue 1, January 2026.
Fried potato consumption is increasingly associated with metabolic disorders, yet preventive strategies remain poorly understood. In a 13‐week mouse model, long‐term potato chip intake induced significant glycolipid metabolic disturbances and tissue damage, which were ameliorated by fish oil supplementation through modulation of inflammation, hepatic ...
Xuzhi Wan, Xiaoran Song, Yingyu Huang, Qi Lu, Denghui Meng, Xiaohui Liu, Anli Wang, Pan Zhuang, Yilei Fan, Jingjing Jiao, Yu Zhang   +10 more
wiley   +1 more source

Ligand specificity and adaptability revealed by the first Guanine-II riboswitch tertiary structure. [PDF]

Nucleic Acids Res
Li H, Shen X, Xu X, Tai X, He M, Zhang J, Ren A.   +6 more
europepmc   +1 more source

Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status

, 2017
Matheus D. Baldissera, Carine F. Souza, Pedro H. Doleski, Sílvia González Monteiro, ALEXSANDRO SILVEIRA DA SILVA, Bernardo Baldisserotto   +5 more
openalex   +2 more sources

Edible Seeds in the Fight Against Hypertension: A Review of In Vitro, In Vivo, and Clinical Evidences With a Mechanistic Insight of Bioactive Compounds

Food Frontiers, Volume 7, Issue 1, January 2026.
The presented review provides the potential antihypertensive benefits of traditionally employed edible seeds, presenting new perspectives and avenues for future research. ABSTRACT Hypertension, often referred to as a silent killer, is responsible for 7.5 million deaths, representing approximately 12.8% of all global mortality.
Jinmin Shi, Mohamad Fawzi Mahomoodally, Ahmed Abduljalal Abduljabbar, Ruttun Bushra Umme Zainab, Katharigatta N. Venugopala, Gokhan Zengin, Sakina Yagi, Meng‐Yao Li, Xuebo Hu   +8 more
wiley   +1 more source

Decreased purine ingestion, increased molybdenum ingestion, and the decline in amyotrophic lateral sclerosis on Guam. [PDF]

Front Nutr
Bourke CA.
europepmc   +1 more source

Studies on Xanthine Derivatives. II

, 1954
Teiji Ukai, Yuzuru Yamamoto, Shoichi Kanetomo   +2 more
openalex   +2 more sources