Results 91 to 100 of about 44,980 (368)
Arthritis &Rheumatology, Accepted Article.Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun +19 more
wiley +1 more source
Epidemiological study of school performance and asthma medications among asthmatic Egyptian school children [PDF]
, 2014 Background: Childhood asthma is a major health problem in Egypt and worldwide. Barriers to reducing the burden of asthma include symptom-based rather than disease-based approaches, tendency of care to be ‘‘acute’’ rather than “regular” and cultural ...
Aly, Gamal S +3 more
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods This Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE),
Saad Hanif Abbasi +4 more
wiley +1 more source
Journal of Asthma and Allergy, 2022 Hye Jung Park,1 Soyoung Jeon,2 Hye Sun Lee,2 Bo Yeon Kim,3 Yu Jin Chae,3 Gui Ok Kim,3 Jung-Won Park,4,5 Jae-Hyun Lee4,5 1Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea ...
Park HJ +7 more
doaj
Airway smooth muscle as a target of asthma therapy: history and new directions
Respiratory Research, 2006 Ultimately, asthma is a disease characterized by constriction of airway smooth muscle (ASM). The earliest approach to the treatment of asthma comprised the use of xanthines and anti-cholinergics with the later introduction of anti-histamines and anti ...
Killian Kieran, Janssen Luke J
doaj +1 more source
The Mechanism of Conversion of Xanthine Dehydrogenase to Xanthine Oxidase
, 1998 Xanthine dehydrogenase and xanthine oxidase are complex metalloflavoproteins that represent alternate forms of the same gene product. The cDNAs encoding the enzymes have been cloned from several sources, and structural information is becoming available.
Tomoko Nishino +4 more
openaire +2 more sources
Quinone-Enhanced Reduction of Nitric Oxide by Xanthine/Xanthine Oxidase [PDF]
Chemical Research in Toxicology, 2009 The quinones 1,4-naphthoquinone, methyl-1,4-naphthoquinone, tetramethyl-1,4-benzoquinone, 2,3-dimethoxy-5-methyl-1,4-benzoquinone, 2,6-dimethylbenzoquinone, 2,6-dimethoxybenzoquinone, and 9,10-phenanthraquinone enhance the rate of nitric oxide reduction by xanthine/xanthine oxidase in nitrogen-saturated phosphate buffer (pH 7.4).
Antonio E. Alegria, Pedro Sanchez-Cruz
openaire +3 more sources
Studies on 8-tertbutyl Caffeine: An in silico approach to mechanistic studies [PDF]
, 2014 Amminecobalt (III) promoted aerial oxidation of alkyl hydrazines undergoing homolytic alkylation of xanthines selectively at C-8 position. No modeling studies have been done previously on these compounds.
Suravajhala, Renuka +1 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy +4 more
wiley +1 more source
METHOD FOR MODULATING EICOSANOID MEDIATED IMMUNE RESPONSES IN ARTHROPODS [PDF]
, 2000 The invention is directed to compositions which alter the health of invertebrate organisms by affecting eicosanoid mediated immune responses, and methods of using the compositions.
Stanley, David W.
core +1 more source