Synthesis of 2-Substituted 9-Oxa-Guanines {5-Aminooxazolo 5,4-D Pyrimidin-7(6H)-Ones} and 9-Oxa-2-Thio-Xanthines{5-Mercaptooxazolo 5,4-D Pyrimidin-7(6H)-Ones} [PDF]
, 2008 Oxazolo[5,4-d] pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives.
Bai, Yan +4 more
core +3 more sources
Xanthine oxidoreductase and xanthine oxidase in human cornea.
Histology and histopathology, 2002 Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid. The enzyme complex exists in separate but interconvertible forms, xanthine dehydrogenase and xanthine oxidase, which generate reactive oxygen species (ROS), a well known ...
Cejkova, J. +3 more
openaire +4 more sources
Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca 2+ release [PDF]
, 2015 Objective Caffeine reduces toxic Ca2+ signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental ...
Booth, David M +15 more
core +2 more sources
Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders
Marine Drugs, 2021 Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea.
Mariano Catanesi +5 more
doaj +1 more source
Extraterrestrial nucleobases in the Murchison meteorite [PDF]
Earth and Planetary Science Letters 270, 130-136. 15 June 2008, 2008 Carbon-rich meteorites, carbonaceous chondrites, contain many biologically relevant organic molecules and delivered prebiotic material to the young Earth. We present compound-specific carbon isotope data indicating that measured purine and pyrimidine compounds are indigenous components of the Murchison meteorite.
arxiv +1 more source
FEBS Open Bio, 2019 In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen +4 more
doaj +1 more source
Absence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardium [PDF]
Biochemical and Biophysical Research Communications, 1986 We directly measured the activity of the enzymes xanthine oxidase and xanthine dehydrogenase in rabbit and rat hearts, using a sensitive radiochemical assay. Neither xanthine oxidase activity nor xanthine dehydrogenase activity was detected in the rabbit heart.
Grum, Cyril M. +3 more
openaire +3 more sources
The Role of Xanthine Oxidase and Xanthine Dehydrogenase in Skin Ischemia [PDF]
Journal of Surgical Research, 1994 The importance of sequential events which lead to skin necrosis has significant implications in trauma, vascular injury, and wound healing. In this series of experiments, we tested the hypothesis that xanthine oxidase (XO) activity was increased along an ischemic gradient of a skin flap and that the XO enzyme activity correlated with an increase in ...
Rees, Riley S. +6 more
openaire +4 more sources
Notes on the frugivorous fruit fly (Diptera: Tephritidae) fauna of western Africa, with description of a new Dacus species [PDF]
, 2013 The species richness of the frugivorous fruit fly fauna of western African (in particular of Ivory Coast, Ghana, Togo, Benin and Nigeria) is discussed.
DeMeyer, Marc +2 more
core +3 more sources