Hematopoietic Antigen Presenting Cells Fine-Tune the Effector Phenotype of Intrathymic Unconventional αβ T Cells. [PDF]
Eur J ImmunolWang Y +12 more
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Cell-Type-Specific WTAP and ALKBH5-Mediated m<sup>6</sup>A Methylation Orchestrates Mental Disorders via Gut-Brain Axis Metabolite Signaling: Multi-Omics Evidence and Pyroptosis-Associated Loop Mechanism. [PDF]
CNS Neurosci TherZhang J, Liu X, Liu X, Zhao L, Bi J.
europepmc +1 more source
Glial Triad in Diabetic Neuropathy: Central Players in Neuropathic Pain Pathogenesis and Disease-Modifying Therapeutic Avenues. [PDF]
BiomedicinesFu S +6 more
europepmc +1 more source
Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice
Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and miceopenaire +1 more source
Resurrected Ancestors Reveal Origins of Metamorphism in XCL1 [PDF]
Trends in Biochemical Sciences, 2021 In a recent study, Dishman et al. resurrected ancestors of the metamorphic chemokine, XCL1, inferred through phylogenetics, and found that metamorphism arose in the XCL1 lineage ~150 million years ago. A zigzagging evolutionary path suggests that the metamorphic properties are adaptive and reveals three design principles that could be used for ...
Patricia J LiWang +2 more
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Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1 [PDF]
ACS Infectious Diseases, 2020 Abstract Antimicrobial peptides (AMPs) are a class of molecules which generally kill pathogens via preferential cell membrane disruption. Chemokines are a family of signaling proteins that direct immune cell migration and share a conserved α–β tertiary structure.
Ernest Y Lee +2 more
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XCL1 And XCR1 in the Immune System
Microbes and Infection, 2012XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response.
Yousuke Takahama
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Traumatic Brain Injury in Mice Induces Changes in the Expression of the XCL1/XCR1 and XCL1/ITGA9 Axes [PDF]
Pharmacological Reports, 2020 Abstract Background Every year, millions of people suffer from various forms of traumatic brain injury (TBI), and new approaches with therapeutic potential are required. Although chemokines are known to be involved in brain injury, the importance of X-C motif chemokine ligand 1 (XCL1) and its receptors, X-C motif chemokine receptor 1 (XCR1) and alpha-9
Domenico Mercurio +2 more
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The XCL1-XCR1 axis has a potential role in the recruitment of immune cells to the site of inflammation. The present study aimed to examine the relation of XCL1 serum levels with Multiple sclerosis (MS) and HTLV-1-associated myelopathy (HAM), as chronic inflammatory diseases of the central nervous system (CNS).
Zohreh Vahidi, Effat Saghi
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