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Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice
Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and miceopenaire
Traumatic brain injury in mice induces changes in the expression of the XCL1/XCR1 and XCL1/ITGA9 axes [PDF]
Pharmacological Reports, 2020 Abstract Background Every year, millions of people suffer from various forms of traumatic brain injury (TBI), and new approaches with therapeutic potential are required. Although chemokines are known to be involved in brain injury, the importance of X-C motif chemokine ligand 1 (XCL1) and its receptors, X-C motif chemokine receptor 1 (XCR1) and alpha-9
Domenico Mercurio +2 more
exaly +3 more sources
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XCL1 and XCR1 in the immune system
Microbes and Infection, 2012XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response.
Yousuke Takahama
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Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1 [PDF]
ACS Infectious Diseases, 2020 Antimicrobial peptides (AMPs) are a class of molecules which generally kill pathogens via preferential cell membrane disruption. Chemokines are a family of signaling proteins that direct immune cell migration and share a conserved α-β tertiary structure.
Ernest Y Lee +2 more
exaly +4 more sources
Microbial Pathogenesis, 2023
The XCL1-XCR1 axis has a potential role in the recruitment of immune cells to the site of inflammation. The present study aimed to examine the relation of XCL1 serum levels with Multiple sclerosis (MS) and HTLV-1-associated myelopathy (HAM), as chronic inflammatory diseases of the central nervous system (CNS).
Mohammadali Nahayati, Zohreh Vahidi
exaly +3 more sources
The XCL1-XCR1 axis has a potential role in the recruitment of immune cells to the site of inflammation. The present study aimed to examine the relation of XCL1 serum levels with Multiple sclerosis (MS) and HTLV-1-associated myelopathy (HAM), as chronic inflammatory diseases of the central nervous system (CNS).
Mohammadali Nahayati, Zohreh Vahidi
exaly +3 more sources
Glycosylated recombinant human XCL1/lymphotactin exhibits enhanced biologic activity
Journal of Immunological Methods, 2005Chemokines are a family of small, secreted chemoattractant cytokines that regulate distribution and function of leukocytes during immune responses. While most chemokines are members of the CC or CXC subgroups, XCL1, also known as lymphotactin, is the sole member of the C subgroup.
Annabelle Chua +2 more
exaly +3 more sources
Annals of Hematology, 2017
There is no information about XCL1 in patients with acute lymphoblastic leukemia (ALL). The objective of this study was to correlate the serum levels of XCL1 and survival in ALL patients. Only ALL patients older than 12 months were considered to participate.
JOSÉ CARLOS Jaime-Perez +2 more
exaly +3 more sources
There is no information about XCL1 in patients with acute lymphoblastic leukemia (ALL). The objective of this study was to correlate the serum levels of XCL1 and survival in ALL patients. Only ALL patients older than 12 months were considered to participate.
JOSÉ CARLOS Jaime-Perez +2 more
exaly +3 more sources
CXCL10/XCL1 fusokine elicits in vitro and in vivo chemotaxis
Biotechnology Letters, 2014Fusokines are proteins formed by the fusion of two cytokines. They have greater bioavailability and therapeutic potential than individual cytokines or a combination of different cytokines. Interferon-gamma-inducible protein 10 (CXCL10) and lymphotactin (XCL1) are members of the chemotactic family of cytokines, which induce tumor regression by eliciting
Yessica E, Sanchez-Lugo +9 more
openaire +2 more sources
Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice
Biochemical and Biophysical Research Communications, 2010Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs.
Katsuaki Hoshino +2 more
exaly +3 more sources