Results 1 to 10 of about 7,624 (217)

Development and function of chicken XCR1+ conventional dendritic cells

Frontiers in Immunology, 2023
Conventional dendritic cells (cDCs) are antigen-presenting cells (APCs) that play a central role in linking innate and adaptive immunity. cDCs have been well described in a number of different mammalian species, but remain poorly characterised in the ...
Zhiguang Wu, Barbara Shih, Barbara Shih, Joni Macdonald, Dominique Meunier, Kris Hogan, Cosmin Chintoan-Uta, Hazel Gilhooley, Tuanjun Hu, Mariana Beltran, Neil C. Henderson, Neil C. Henderson, Helen M. Sang, Mark P. Stevens, Michael J. McGrew, Adam Balic, Adam Balic   +16 more
exaly   +7 more sources

XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

Cell Reports, 2023
Summary: The contribution of cross-presenting XCR1+ dendritic cells (DCs) and SIRPα+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections remains poorly characterized.
Domenjo-Vila Eva, Pedragosa M, Gennady A Bocharov   +2 more
exaly   +7 more sources

Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression [PDF]

eLife
Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong, Le Yang, Kexin He, Yanrong Gu, Binhui Zhou, Tingting Jia, Toby Lawrence, Marie Malissen, Guixue Wang, Rong Huang, Hui Wang, Bernard Malissen, Yinming Liang, Lichen Zhang   +16 more
doaj   +5 more sources

PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis [PDF]

Nature Communications, 2021
Dendritic cells initiate and regulate adaptive immunity and differ according to gut anatomical location. Here the authors show that DC residing in the upper and lower intestines show differential PD-L1 and XCR1 expression and drive specific T cell ...
Thais Moreira, Davide Mangani, Laura M Cox   +2 more
exaly   +5 more sources

Molecular basis for chemokine recognition and activation of XCR1 [PDF]

Proceedings of the National Academy of Sciences of the United States of America
The X-C motif chemokine receptor XCR1, which selectively binds to the chemokine XCL1, is highly expressed in conventional dendritic cells subtype 1 (cDC1s) and crucial for their activation. Modulating XCR1 signaling in cDC1s could offer novel opportunities in cancer immunotherapy and vaccine development by enhancing the antigen ...
Zhang X, Schlimgen RR, Singh S, Tomani MP, Volkman BF, Zhang C.   +5 more
exaly   +5 more sources

The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis [PDF]

JCI Insight
Type 1 diabetes (T1D) is precipitated by the autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans. Chemokines have been identified as major conductors of islet infiltration by autoaggressive leukocytes, including
Camilla Tondello, Christine Bender, Gregory J. Golden, Deborah Puppe, Elisa Blickberndt, Monika Bayer, Giulia K. Buchmann, Josef Pfeilschifter, Malte Bachmann, Edith Hintermann, Ralf P. Brandes, Michael R. Betts, Richard A. Kroczek, Urs Christen   +13 more
doaj   +5 more sources

Ontogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα [PDF]

Frontiers in Immunology, 2014
In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function.
Martina eBecker, Steffen eGüttler, Annabell eBachem, Evelyn eHartung, Ahmed eMora, Anika eJäkel, Andreas eHutloff, Volker eHenn, Hans Werner Mages, Stephanie eGurka, Richard A. Kroczek   +10 more
doaj   +5 more sources

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in intestinal immune homeostasis [PDF]

Scientific Reports, 2016
Abstract Intestinal immune homeostasis requires dynamic crosstalk between innate and adaptive immune cells. Dendritic cells (DCs) exist as multiple phenotypically and functionally distinct sub-populations within tissues, where they initiate immune responses and promote homeostasis. In the gut, there exists a minor
Ken J Ishii, Katsuaki Hoshino, Florent Ginhoux   +2 more
exaly   +3 more sources

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis [PDF]

Frontiers in Immunology
IntroductionMultiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system (CNS), in which various immune cells contribute to disease progression, yet the role of dendritic cells (DCs) remains incompletely understood ...
Xingyu Rong, Hai Wang, Shintaro Muraoka, Takuya Uehata, Masanori Yoshinaga, Tsuneyasu Kaisho, Osamu Takeuchi   +6 more
doaj   +2 more sources

The role of the chemokine receptor XCR1 in breast cancer cells

Breast Cancer: Targets and Therapy, 2017
Xiao Li Yang,1,* Li Guo Qi,2,* Feng Juan Lin,1 Zhou Luo Ou1 1Department of Oncology, Breast Cancer Institute, Fudan University, Shanghai Cancer Center, Shanghai, 2Department of Neurosurgery, Taian City Central Hospital, Taian, Shangdong, People’s ...
Yang XL, Qi LG, Lin FJ, Ou ZL
doaj   +5 more sources