Results 131 to 140 of about 4,391 (150)

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in protection against West Nile virus within the CNS

The Journal of Immunology, 2021
Abstract West Nile Virus (WNV) is a leading cause of mosquito-borne neuroinvasive disease in the US. Following infection, WNV can cause neuronal injury and disease. Previous studies have shown that the proper activation of virus-specific T cells results in protection from WNV infection and any associated disease.
Douglas M Durrant, Alejandro Cortes, Marina O Alvarado   +2 more
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Magnetic properties of Co2-xCr1+xAl (x=0,0.4)

AIP Conference Proceedings, 2020
Co2-xCr1+xAl for x=0 and 0.4 (x=0.4 means 20% of Co atoms of Co2CrAl have been replaced by Cr atoms) have been prepared in tri-arc melting furnace. XRD pattern with Reitveld refinement analysis of both samples indicate Heusler alloy like L21 structure with B2 disorder. It is revealed by Magnetization measurement that both compounds show paramagnetic to
Amrita Datta, Mantu Modak, Sangam Banerjee   +2 more
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Genetic diversity of chemokine XCL1 and its receptor XCR1 in murine rodents

Developmental & Comparative Immunology, 2019
The chemokine ligand XCL1 plays critical roles in immune responses with diverse physiological and pathological implications through interactions with a cognate G protein-coupled receptor XCR1. To shed insight into their versatile nature, we analyzed genetic variations of XCL1 and XCR1 in murine rodents, including commonly-used model organisms Mus ...
Feifei, Xu, Dan, He, Ruihong, Ning, Bo, Zeng, Cody W, Thompson, Ying, Li, Dawei, Wang, Yan, Li   +7 more
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Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Biochemical and Biophysical Research Communications, 2010
Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs.
Chihiro, Yamazaki, Rie, Miyamoto, Katsuaki, Hoshino, Yuri, Fukuda, Izumi, Sasaki, Masuyoshi, Saito, Hironori, Ishiguchi, Takahiro, Yano, Takahiro, Sugiyama, Hiroaki, Hemmi, Takashi, Tanaka, Eri, Hamada, Takeshi, Hirashima, Ryuichi, Amakawa, Shirou, Fukuhara, Shosaku, Nomura, Tomoki, Ito, Tsuneyasu, Kaisho   +17 more
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Neutrophils and B Cells Express XCR1 Receptor and Chemotactically Respond to Lymphotactin

Biochemical and Biophysical Research Communications, 2001
The C chemokine lymphotactin (Lptn) has been reported to act specifically on CD4(+) and CD8(+) T lymphocytes and natural killer (NK) cells, but not monocytes. However, the chemotactic effect of Lptn on other types of hematopoietic cells has not been well studied.
H, Huang, F, Li, C M, Cairns, J R, Gordon, J, Xiang   +4 more
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Identification of Viral Macrophage Inflammatory Protein (vMIP)-II as a Ligand for GPR5/XCR1

Biochemical and Biophysical Research Communications, 2000
Lymphotactin is unique among chemokines in that it contains only two of four conserved cysteines and may possess a structure less constrained than other chemokines. The viral chemokine vMIP-II, which presumably has a structure similar to that of CC chemokines has been shown to inhibit many chemokine receptors, but its activity at GPR5/XCR1 has not been
L, Shan, X, Qiao, E, Oldham, D, Catron, H, Kaminski, D, Lundell, A, Zlotnik, E, Gustafson, J A, Hedrick   +8 more
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In Vivo Ablation of a Dendritic Cell Subset Expressing the Chemokine Receptor XCR1

2016
Dendritic cells (DCs) are one of the key populations controlling immune responses. To establish a cell depletion system in vivo, human diphtheria toxin (DT) receptor (DTR) is transduced to the mice in which DTR is expressed under the control of a specific promoter. In these mice, DTR-expressing cells are inducibly depleted after DT injection.
Hiroaki, Hemmi, Katsuaki, Hoshino, Tsuneyasu, Kaisho   +2 more
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[Cloning and in vitro expression of XCR1 of Rhesus macaque].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2017
Objective To characterize the gene of Rhesus macaque XC chemokine receptor 1 (XCR1) and express it in HEK293T cells. Methods Rhesus macaque XCR1 gene was amplified by reverse transcription PCR (RT-PCR) and rapid amplification of cDNA end (RACE). The sequence alignment was compared with XCR1 of other species in GenBank. Eukaryotic expression plasmid 3.1-
Lei, Yu, Dong, Li, Wenrong, Yao, Fengjie, Wang, Yanfang, Cui, Guibo, Yang   +5 more
openaire   +1 more source

Transcriptomic analyses of chemokines reveal that down-regulation of XCR1 is associated with advanced hepatocellular carcinoma

Biochemical and Biophysical Research Communications, 2018
Chemokines are essential coordinators of cellular migration and cell-cell interactions, therefore considerable attention has been paid to the application of chemokines to cancer immunotherapy. In this study, we screened for the expression levels of 58 human chemokines/chemokine receptors in hepatocellular carcinoma (HCC) by using samples from the TCGA ...
Wang, Yanru, Bai, Zhenyu, Niu, Zhengchuan, Qi, Qi, Liang, Chunmin, Yao, Weiqiang   +5 more
openaire   +2 more sources

In Vitro Generation of Human XCR1+ Dendritic Cells from CD34+ Hematopoietic Progenitors

2016
Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells which play a key role in orchestrating immune defenses. Most of the information gained on human DC biology was derived from studies conducted with DCs generated in vitro from peripheral blood CD14(+) monocytes (MoDCs) or from CD34(+) hematopoietic progenitors.
Sreekumar Balan, Marc Dalod
openaire   +2 more sources