Results 151 to 160 of about 5,269 (176)

Functional Expression of the Chemokine Receptor XCR1 on Oral Epithelial Cells

Journal of Pathology, 2010
Chemokines are chemoattractant cytokines which act on specific receptors and play an important role in leukocyte migration as well as physiological and pathological processes.
Craig Murdoch, Syed Ali Khurram, Simon A Whawell   +2 more
exaly   +5 more sources

XCR1 Expression Distinguishes Human Conventional Dendritic Cell Type 1 With Full Effector Functions From Their Immediate Precursors [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Dendritic cells (DCs) are major regulators of innate and adaptive immune responses. DCs can be classified into plasmacytoid DCs and conventional DCs (cDCs) type 1 and 2. Murine and human cDC1 share the mRNA expression of XCR1.
Lukas Heger, Christian Lehmann, Diana Dudziak   +2 more
exaly   +3 more sources

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XCL1 And XCR1 in the Immune System

Microbes and Infection, 2012
XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response.
Yousuke Takahama
exaly   +3 more sources

Molecular Basis for Chemokine Recognition and Activation of XCR1

Proceedings of the National Academy of Sciences of the United States of America
The X-C motif chemokine receptor XCR1, which selectively binds to the chemokine XCL1, is highly expressed in conventional dendritic cells subtype 1 (cDC1s) and crucial for their activation. Modulating XCR1 signaling in cDC1s could offer novel opportunities in cancer immunotherapy and vaccine development by enhancing the antigen ...
Cheng Zhang, Brian F Volkman, Roman Schlimgen   +2 more
exaly   +3 more sources

Conservation of a Chemokine System, XCR1 and Its Ligand, XCL1, Between Human and Mice

Biochemical and Biophysical Research Communications, 2010
Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs.
Katsuaki Hoshino, Tsuneyasu Kaisho, Yuri Fukuda-Ohta   +2 more
exaly   +3 more sources

Magnetic properties of Co2-xCr1+xAl (x=0,0.4)

AIP Conference Proceedings, 2020
Co2-xCr1+xAl for x=0 and 0.4 (x=0.4 means 20% of Co atoms of Co2CrAl have been replaced by Cr atoms) have been prepared in tri-arc melting furnace. XRD pattern with Reitveld refinement analysis of both samples indicate Heusler alloy like L21 structure with B2 disorder. It is revealed by Magnetization measurement that both compounds show paramagnetic to
Amrita Datta, Mantu Modak, Sangam Banerjee   +2 more
openaire   +1 more source

Neutrophils and B Cells Express XCR1 Receptor and Chemotactically Respond to Lymphotactin

Biochemical and Biophysical Research Communications, 2001
The C chemokine lymphotactin (Lptn) has been reported to act specifically on CD4(+) and CD8(+) T lymphocytes and natural killer (NK) cells, but not monocytes. However, the chemotactic effect of Lptn on other types of hematopoietic cells has not been well studied.
John R Gordon, Jim Xiang
exaly   +3 more sources

Genetic diversity of chemokine XCL1 and its receptor XCR1 in murine rodents

Developmental & Comparative Immunology, 2019
The chemokine ligand XCL1 plays critical roles in immune responses with diverse physiological and pathological implications through interactions with a cognate G protein-coupled receptor XCR1. To shed insight into their versatile nature, we analyzed genetic variations of XCL1 and XCR1 in murine rodents, including commonly-used model organisms Mus ...
Feifei, Xu, Dan, He, Ruihong, Ning, Bo, Zeng, Cody W, Thompson, Ying, Li, Dawei, Wang, Yan, Li   +7 more
openaire   +2 more sources

Transcriptomic Analyses of Chemokines Reveal That Down-Regulation of XCR1 Is Associated With Advanced Hepatocellular Carcinoma

Biochemical and Biophysical Research Communications, 2018
Chemokines are essential coordinators of cellular migration and cell-cell interactions, therefore considerable attention has been paid to the application of chemokines to cancer immunotherapy. In this study, we screened for the expression levels of 58 human chemokines/chemokine receptors in hepatocellular carcinoma (HCC) by using samples from the TCGA ...
Chunmin Liang, Zhengchuan Niu, Yanru Wang   +2 more
exaly   +3 more sources

Identification of Viral Macrophage Inflammatory Protein (vMIP)-II as a Ligand for GPR5/XCR1

Biochemical and Biophysical Research Communications, 2000
Lymphotactin is unique among chemokines in that it contains only two of four conserved cysteines and may possess a structure less constrained than other chemokines. The viral chemokine vMIP-II, which presumably has a structure similar to that of CC chemokines has been shown to inhibit many chemokine receptors, but its activity at GPR5/XCR1 has not been
L, Shan, X, Qiao, E, Oldham, D, Catron, H, Kaminski, D, Lundell, A, Zlotnik, E, Gustafson, J A, Hedrick   +8 more
openaire   +2 more sources