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Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1

Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1
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XCL1 and XCR1 in the immune system

Microbes and Infection, 2012
XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response.
Yousuke Takahama
exaly   +3 more sources

Crucial roles of XCR1-expressing dendritic cells and the XCR1-XCL1 chemokine axis in protection against West Nile virus within the CNS

The Journal of Immunology, 2021
Abstract West Nile Virus (WNV) is a leading cause of mosquito-borne neuroinvasive disease in the US. Following infection, WNV can cause neuronal injury and disease. Previous studies have shown that the proper activation of virus-specific T cells results in protection from WNV infection and any associated disease.
Douglas M Durrant, Alejandro Cortes, Marina O Alvarado   +2 more
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Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice

Biochemical and Biophysical Research Communications, 2010
Understanding dendritic cell (DC) subset functions should lead to the development of novel types of vaccine. Here we characterized expression of XC chemokine receptor 1 (XCR1) and its ligand, XCL1. Murine XCR1 was the only chemokine receptor selectively expressed in CD8alpha(+) conventional DCs.
Katsuaki Hoshino, Izumi Sasaki, Tsuneyasu Kaisho   +2 more
exaly   +3 more sources

Functional expression of the chemokine receptor XCR1 on oral epithelial cells

Journal of Pathology, 2010
AbstractChemokines are chemoattractant cytokines which act on specific receptors and play an important role in leukocyte migration as well as physiological and pathological processes. We investigated the role of the chemokine receptor XCR1 and its ligand lymphotactin (Lptn/XCL1) in the regulation of oral epithelial cell behaviour.
S A Khurram, Simon A Whawell, Craig Murdoch   +2 more
exaly   +3 more sources

Magnetic properties of Co2-xCr1+xAl (x=0,0.4)

AIP Conference Proceedings, 2020
Co2-xCr1+xAl for x=0 and 0.4 (x=0.4 means 20% of Co atoms of Co2CrAl have been replaced by Cr atoms) have been prepared in tri-arc melting furnace. XRD pattern with Reitveld refinement analysis of both samples indicate Heusler alloy like L21 structure with B2 disorder. It is revealed by Magnetization measurement that both compounds show paramagnetic to
Amrita Datta, Mantu Modak, Sangam Banerjee   +2 more
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Neutrophils and B Cells Express XCR1 Receptor and Chemotactically Respond to Lymphotactin

Biochemical and Biophysical Research Communications, 2001
The C chemokine lymphotactin (Lptn) has been reported to act specifically on CD4(+) and CD8(+) T lymphocytes and natural killer (NK) cells, but not monocytes. However, the chemotactic effect of Lptn on other types of hematopoietic cells has not been well studied.
John R Gordon, Jim Xiang
exaly   +3 more sources

Genetic diversity of chemokine XCL1 and its receptor XCR1 in murine rodents

Developmental & Comparative Immunology, 2019
The chemokine ligand XCL1 plays critical roles in immune responses with diverse physiological and pathological implications through interactions with a cognate G protein-coupled receptor XCR1. To shed insight into their versatile nature, we analyzed genetic variations of XCL1 and XCR1 in murine rodents, including commonly-used model organisms Mus ...
Feifei, Xu, Dan, He, Ruihong, Ning, Bo, Zeng, Cody W, Thompson, Ying, Li, Dawei, Wang, Yan, Li   +7 more
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Identification of Viral Macrophage Inflammatory Protein (vMIP)-II as a Ligand for GPR5/XCR1

Biochemical and Biophysical Research Communications, 2000
Lymphotactin is unique among chemokines in that it contains only two of four conserved cysteines and may possess a structure less constrained than other chemokines. The viral chemokine vMIP-II, which presumably has a structure similar to that of CC chemokines has been shown to inhibit many chemokine receptors, but its activity at GPR5/XCR1 has not been
L, Shan, X, Qiao, E, Oldham, D, Catron, H, Kaminski, D, Lundell, A, Zlotnik, E, Gustafson, J A, Hedrick   +8 more
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