Results 11 to 20 of about 7,624 (217)

XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Dendritic cells (DCs) are major regulators of innate and adaptive immune responses. DCs can be classified into plasmacytoid DCs and conventional DCs (cDCs) type 1 and 2. Murine and human cDC1 share the mRNA expression of XCR1.
Lukas Heger, Christian H K Lehmann, Lukas Amon   +2 more
exaly   +4 more sources

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science
Trophoblast–immune cell communication is crucial during pregnancy, with impairments linked to adverse outcomes. The accumulation of decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) in the third trimester is vital for fetal ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
doaj   +3 more sources

The XCL1-XCR1 axis supports intestinal tissue residency and antitumor immunity. [PDF]

J Exp Med
Tissue-resident memory T cells (TRM) provide frontline protection against pathogens and emerging malignancies. Tumor-infiltrating lymphocytes (TIL) with TRM features are associated with improved clinical outcomes. However, the cellular interactions that program TRM differentiation and function are not well understood.
Ferry A, Mempel KM, Monell A, Reina-Campos M, Scharping NE, Heeg M, Takehara KK, Schokrpur S, Kuo N, Saddawi-Konefka R, Gutkind JS, Goldrath AW.   +11 more
europepmc   +4 more sources

RUNX2 Phase Separation Mediates Long‐Range Regulation Between Osteoporosis‐Susceptibility Variant and XCR1 to Promote Osteoblast Differentiation [PDF]

Advanced Science
GWASs have identified many loci associated with osteoporosis, but the underlying genetic regulatory mechanisms and the potential drug target need to be explored.
Yan Zhang, Xin‐Hao Li, Pai Peng, Zi‐Han Qiu, Chen‐Xi Di, Xiao‐Feng Chen, Nai‐Ning Wang, Fei Chen, Yin‐Wei He, Zhong‐Bo Liu, Fan Zhao, Dong‐Li Zhu, Shan‐Shan Dong, Shou‐Ye Hu, Zhi Yang, Yi‐Ping Li, Yan Guo, Tie‐Lin Yang   +17 more
doaj   +3 more sources

CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming [PDF]

Immunity, 2017
Adaptive cellular immunity is initiated by antigen-specific interactions between T lymphocytes and dendritic cells (DCs). Plasmacytoid DCs (pDCs) support antiviral immunity by linking innate and adaptive immune responses. Here we examined pDC spatiotemporal dynamics during viral infection to uncover when, where, and how they exert their functions.
Sarah Eickhoff, Sammy Bedoui, Christian Kurts   +2 more
exaly   +4 more sources

Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells

Cell Reports, 2019
Summary: Type I interferons (IFNs) play important roles in antitumor immunity. We generated IFN-α-producing cells by genetically engineered induced pluripotent stem cell (iPSC)-derived proliferating myeloid cells (iPSC-pMCs).
Nobuhiro Tsuchiya, Tianyi Liu, Azusa Miyashita   +2 more
exaly   +4 more sources

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis [PDF]

Nature Medicine, 2021
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver failure and liver cancer. Chronic necro-inflammation is a critical factor in development of NASH, yet the cellular and molecular mechanisms of immune dysregulation in this ...
Aleksandra Deczkowska, Eyal David, Pierluigi Ramadori, Dominik Pfister, Michal Safran, Baoguo Li, Amir Giladi, Diego Adhemar Jaitin, Oren Barboy, Merav Cohen, Ido Yofe, Chamutal Gur, Shir Shlomi-Loubaton, Sandrine Henri, Yousuf Suhail, Mengjie Qiu, Shing Kam, Hila Hermon, Eylon Lahat, Gil Ben Yakov, Oranit Cohen-Ezra, Yana Davidov, Mariya Likhter, David Goitein, Susanne Roth, Achim Weber, Bernard Malissen, Assaf Weiner, Ziv Ben-Ari, Mathias Heikenwälder, Eran Elinav, Ido Amit   +31 more
semanticscholar   +5 more sources

Cloning of Grass Carp Chemokine XC Receptor 1 (XCR1) Gene and Evaluation of Its Expression in Various Organs after GCRV Infection

Fishes, 2022
Interaction between the chemokine receptor XCR1 and its ligand is closely related to the immune function in animals; however, there are only a few reports on role of XCR1 in the immune system of fish. We aimed to analyze the expression of XCR1 in various
Hailuo Yu, Yi Liu, Tiaoyi Xiao, Hongquan Wang, Baohong Xu   +4 more
doaj   +2 more sources

Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation

Frontiers in Immunology, 2012
Cross-presentation of antigen by dendritic cells (DCs) to CD8+ T cells is a fundamentally important mechanism in the defense against pathogens and tumors.
Annabell Bachem, Ahmed Mora, Maud Plantinga   +2 more
exaly   +3 more sources

New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies

Frontiers in Immunology, 2022
Recent studies have indicated the involvement of chemokine-C-motif ligand 1 (XCL1) in nociceptive transmission; however, the participation of its two receptors, canonical chemokine-C-motif receptor 1 (XCR1) and integrin alpha-9 (ITGA9), recently ...
Agata Ciechanowska, Ewelina Rojewska, Anna Piotrowska, Justyna Barut, Katarzyna Pawlik, Katarzyna Ciapała, Grzegorz Kreiner, Joanna Mika   +7 more
doaj   +2 more sources