Results 21 to 30 of about 7,624 (217)

Cross-Presenting XCR1+ Dendritic Cells as Targets for Cancer Immunotherapy [PDF]

Cells, 2020
The use of dendritic cells (DCs) to generate effective anti-tumor T cell immunity has garnered much attention over the last thirty-plus years. Despite this, limited clinical benefit has been demonstrated thus far. There has been a revival of interest in DC-based treatment strategies following the remarkable patient responses observed with novel ...
Katherine M. Audsley, Alison M. McDonnell, Jason Waithman   +2 more
openaire   +4 more sources

Harnessing human cross-presenting CLEC9A+XCR1+ dendritic cells for immunotherapy [PDF]

Frontiers in Immunology, 2014
Dendritic cells (DC) are professional antigen presenting cells (APCs) that play a pivotal role in the induction and regulation of immune responses, including the induction of cytotoxic T lymphocyte (CTL) responses. They are an important focus for the development of vaccines against cancers and many pathogens, including HIV and malaria, where CTL ...
Kirsteen eTullett, Kirsteen eTullett, Kirsteen eTullett, Mireille eLahoud, Mireille eLahoud, Kristen J Radford, Kristen J Radford   +6 more
doaj   +4 more sources

XCR1: A promising prognostic marker that pinpoints targeted and immune-based therapy in hepatocellular carcinoma

Heliyon
Objectives: The lymphotactin receptor X–C motif chemokine receptor 1 (XCR1) is an essential member of the chemokine receptor family and is related to tumor development and progression.
Wei Wu, Zhen Bao, Kai Zhu, Danjun Song, Weijian Yang, Jun Luo, Jiaping Zheng, Guoliang Shao, Junfeng Huang   +8 more
doaj   +2 more sources

The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin [PDF]

Scientific Reports, 2017
XCR1 is selectively expressed on a conventional dendritic cell subset, the cDC1 subset, through phylogenetically distant species. The outcome of antigen-targeting to XCR1 may therefore be similar across species, permitting the translation of results from
Charlotte Deloizy, Even Fossum, Christophe Barnier-Quer, Céline Urien, Tiphany Chrun, Audrey Duval, Maelle Codjovi, Edwige Bouguyon, Pauline Maisonnasse, Pierre-Louis Hervé, Céline Barc, Olivier Boulesteix, Jérémy Pezant, Christophe Chevalier, Nicolas Collin, Marc Dalod, Bjarne Bogen, Nicolas Bertho, Isabelle Schwartz-Cornil   +18 more
doaj   +7 more sources

The Role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation by Murine and Human Dendritic Cells

Frontiers in Immunology, 2012
Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation.
Richard A. Kroczek, Volker eHenn
exaly   +3 more sources

Intratumoral sustained release of resiquimod with ablative fractional laser induces efficacy in a cutaneous squamous cell carcinoma mouse model [PDF]

Frontiers in Immunology
IntroductionThe Toll-like receptor (TLR) 7/8 agonist resiquimod has shown promise for precancerous lesions of cutaneous squamous cell carcinoma (cSCC) but remains unexplored as a treatment for cSCC.
Martin Wiinberg, Fredrik Melander, Catharina M. Lerche, Catharina M. Lerche, Thomas L. Andresen, Uffe H. Olesen, Merete Haedersdal   +6 more
doaj   +2 more sources

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
doaj   +2 more sources

Tolerogenic XCR1+ dendritic cell population is dysregulated in HLA-B27 transgenic rat model of spondyloarthritis [PDF]

Arthritis Research & Therapy, 2019
Background Spondyloarthritis (SpA) is a chronic inflammatory disease affecting primarily axial and peripheral joints and sometimes also extra-articular organs, such as the gut.
Kétia Ermoza, Simon Glatigny, Nadège Jah, Vânia Camilo, Hendrick Mambu Mambueni, Luiza M. Araujo, Gilles Chiocchia, Maxime Breban   +7 more
doaj   +5 more sources

Chemokine Receptor Profiles as Predictors of Survival and Early Progression in Follicular Lymphoma [PDF]

eJHaem
Objective: Classical follicular lymphoma (FL) is a heterogeneous malignancy. Early progression within 24 months (POD24) is linked to poor outcomes. However, precise risk stratification remains unclear.
Antonella Zupo, Katrin Pansy, Lukas Gaksch, Julia Waldhart, Andrea Brunner, Johanna Strobl, Marta Szmyra‐Polomka, Sandra Haingartner, Peter V. Tomazic, Hildegard T. Greinix, Barbara Uhl, Julia Feichtinger, Georg Stary, Johannes Haybaeck, Fotini Rosi Vagena, Martin Zacharias, Christine Beham‐Schmid, Peter Neumeister, Katharina Theresa Prochazka, Alexander J. A. Deutsch   +19 more
doaj   +2 more sources

Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions [PDF]

, 2015
International audienceDendritic cells (DCs) were initially defined as mononuclear phagocytes with a dendritic morphology and an exquisite efficiency for naïve T-cell activation.
Bertho, Nicolas, Dalod, Marc, Hosmalin, Anne, Schwartz-Cornil, Isabelle, Vu Manh, Thien-Phong   +4 more
core   +19 more sources