Results 41 to 50 of about 7,624 (217)

Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile

Frontiers in Immunology, 2023
Dendritic cells (DC) play a crucial role in generating and maintaining antiviral immunity. While DC are implicated in the antiviral defense by inducing T cell responses, they can also become infected by Cytomegalovirus (CMV).
Julia Cecilia Madela-Mönchinger, Silver Anthony Wolf, Emanuel Wyler, Agnieszka Bauer, Marius Mischke, Lars Möller, Vanda Juranić Lisnić, Markus Landthaler, Anna Malyshkina, Sebastian Voigt   +9 more
doaj   +1 more source

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2 [PDF]

, 2016
Plasmacytoid dendritic cells (DCs [pDCs]) develop from pre-pDCs, whereas two lineages of conventional DCs (cDCs; cDC1s and cDC2s) develop from lineage-committed pre-cDCs.
Bachem, Bajaña, Bart N. Lambrecht, Bieke Soen, Broos, Broos, Caton, Cerovic, Charlotte L. Scott, Cisse, Danny Huylebroeck, De Craene, Denecker, Dominguez, Edelson, Geert Berx, Gert Van Isterdael, Ghosh, Gillian Blancke, Goossens, Grajales-Reyes, Greter, Guilliams, Hacker, Haniffa, Hegarty, Helft, Higashi, Hildner, Jackson, Joachim Taminau, Jody Haigh, Kashiwada, Lewis, Li, Liesbet Martens, Liu, Martin Guilliams, Merad, Miller, Murphy, Naik, Nicolas Skrypek, Omilusik, Onai, Persson, Persson, Remacle, Satpathy, Schlitzer, Schlitzer, Scott, Scott, Spits, Swiecki, Tailor, Tamura, Tatari, Tussiwand, van Helden, Welty, Williams, Wouter Saelens, Wu, Yvan Saeys   +64 more
core   +2 more sources

Spatially Restricted Translation of the xCR1 mRNA in Xenopus Embryos [PDF]

Molecular and Cellular Biology, 2009
The xCR1 protein is a maternal determinant and cofactor for nodal signaling in vertebrate embryos. The xCR1 protein accumulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed equally throughout all embryonic cells.
Zhang, Yan, Forinash, Kara D., McGivern, Jered, Fritz, Brian, Dorey, Karel, Sheets, Michael D.   +5 more
openaire   +3 more sources

The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]

PLoS ONE, 2017
The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li, Guoyan Wei, Yimei Cao, Dong Li, Pinghua Li, Jing Zhang, Huifang Bao, Yingli Chen, Yuanfang Fu, Pu Sun, Xingwen Bai, Xueqing Ma, Zengjun Lu, Zaixin Liu   +13 more
doaj   +1 more source

TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8+ T cell and XCR1+ dendritic cell spatial co-localization

Journal for ImmunoTherapy of Cancer, 2022
Background T cell immunoglobulin and mucin domain containing−3 (TIM-3) blocking antibodies are currently being evaluated in clinical trials for solid and hematological malignancies.
Alycia Gardner, Alvaro de Mingo Pulido, Kay Hänggi, Sarah Bazargan, Alexis Onimus, Agnieszka K. Kasprzak, J. Conejo-Garcia, K. Rejniak, B. Ruffell   +8 more
semanticscholar   +1 more source

XCR1+ conventional dendritic cell-induced CD4+ T helper 1 cell activation exacerbates cardiac remodeling after ischemic myocardial injury.

Journal of Molecular and Cellular Cardiology, 2023
Cardiac remodeling has no established therapies targeting inflammation. CD4+ T-cell subsets have been reported to play significant roles in healing process after ischemic myocardial injury, but their detailed mechanisms of activation remain unknown.
H. Inui, M. Nishida, M. Ichii, Hajime Nakaoka, M. Asaji, Seiko Ide, S. Saito, A. Saga, T. Omatsu, Katsunao Tanaka, K. Kanno, Jiuyang Chang, Yinghong Zhu, Takeshi Okada, D. Okuzaki, T. Matsui, T. Ohama, M. Koseki, E. Morii, N. Hosen, S. Yamashita, Y. Sakata   +21 more
semanticscholar   +1 more source

Intratumoral delivery of FLT3L with CXCR3/CCR5 ligands promotes XCR1⁺ cDC1 infiltration and activates anti-tumor immunity. [PDF]

Nat Commun
Tumor infiltration by XCR1⁺ conventional dendritic cells (cDC1) correlates strongly with favorable prognosis and improved responses to immunotherapy. Yet, tumor-driven immunosuppressive programs restrict efficient cDC1 recruitment, highlighting the need ...
Gorline L, do Carmo FLR, Bourdely P, Bornères J, Vaudiau N, Semervil A, Vetillard M, Coulibaly ASK, Jugniot N, Ok A, Bausart M, Fiquet O, Andrade M, Fardol D, Haddar I, Abou Nader Z, Weber J, Theobald H, Collin M, Calmette J, Anselmi G, Fico F, Ginhoux F, Majlessi L, Gautier EL, Saveanu L, Helft J, Dalod M, Dusseaux M, Di Santo JP, Hugues S, Guermonprez P.   +31 more
europepmc   +2 more sources

Therapeutically targeting type I interferon directly to XCR1+ dendritic cells reveals the role of cDC1s in anti-drug antibodies

Frontiers in Immunology, 2023
Conventional type 1 dendritic cells (cDC1s) are superior in antigen cross-presentation and priming CD8+ T cell anti-tumor immunity and thus, are a target of high interest for cancer immunotherapy.
Paul Noe, Joy Wang, K. Chung, Zhiyong Cheng, Jessica J. Field, Xiaomeng Shen, S. Casey, Christa L. Cortesio, Cinthia V. Pastuskovas, H. Phee, K. Tarbell, J. Egen, A. Casbon   +12 more
semanticscholar   +1 more source

Keeping a lid on nodal : transcriptional and translational repression of nodal signalling [PDF]

, 2016
Nodal is an evolutionarily conserved member of the transforming growth factor-β (TGF-β) superfamily of secreted signalling factors. Nodal factors are known to play key roles in embryonic development and asymmetry in a variety of organisms ranging from ...
Robertson, Elizabeth J., Sampath, Karuna
core   +1 more source

XCL1 facilitates the interaction with CD8+ T-cells and XCR1+ DCs within the Cervical Lymph Nodes during WNV encephalitis

Journal of Immunology, 2023
West Nile Virus (WNV), a neurotropic flavivirus, causes encephalitis, especially in elderly and immunocompromised individuals. Previous studies have demonstrated that CNS-localized dendritic cells (DCs) protect against WNV neuroinvasive disease by ...
Kristen De la Torre, D. Durrant
semanticscholar   +1 more source