Results 61 to 70 of about 7,624 (217)

Inflammatory response in traumatic brain and spinal cord injury: The role of XCL1‐XCR1 axis and T cells

CNS Neuroscience & Therapeutics
Traumatic brain injury (TBI) and spinal cord injury (SCI) are acquired injuries to the central nervous system (CNS) caused by external forces that cause temporary or permanent sensory and motor impairments and the potential for long‐term disability or ...
Mingkang Zhang, Xiaonan Han, Liyan Yan, Yikun Fu, Hongwei Kou, Chunfeng Shang, Junmin Wang, Hongjian Liu, Chao Jiang, Jian Wang, Tian Cheng   +10 more
semanticscholar   +1 more source

A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells

Frontiers in Immunology, 2018
The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin is mainly produced by activated CD8+ T cells and natural killer cells.
Kazuhiko Matsuo, Kosuke Kitahata, Fumika Kawabata, Momo Kamei, Yuta Hara, Shiki Takamura, Naoki Oiso, Akira Kawada, Osamu Yoshie, Osamu Yoshie, Takashi Nakayama   +10 more
doaj   +1 more source

Superconductivity, magnetic order, and quadrupolar order in the filled skutterudite system Pr$_{1-x}$Nd$_{x}$Os$_4$Sb$_{12}$

, 2010
Superconductivity, magnetic order, and quadrupolar order have been investigated in the filled skutterudite system Pr$_{1-x}$Nd$_{x}$Os$_4$Sb$_{12}$ as a function of composition $x$ in magnetic fields up to 9 tesla and at temperatures between 50 mK and 10
A. A. Dooraghi, C. C. Robinson, M. B. Maple, M. B. Maple, N. P. Butch, P. Fulde, P.-C. Ho, R. E. Baumbach, T. Yanagisawa, W. M. Yuhasz   +9 more
core   +1 more source

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice [PDF]

, 2017
Significance Our studies indicate that the resident macrophages of the pancreatic islets of Langerhans have a seminal role in the initiation and progression of autoimmune diabetes in NOD mice.
Carrero, Javier A., Ferris, Stephen T., Hu, Hao, McCarthy, Derrick P., Unanue, Emil R., Vomund, Anthony N., Wan, Xiaoxiao, Zinselmeyer, Bernd H.   +7 more
core   +2 more sources

A team effort: natural killer cells on the first leg of the tumor immunity relay race [PDF]

, 2018
Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells.
Duong, Ellen, Fessenden, Timothy B, Spranger-Zimmermann, Stefani   +2 more
core   +1 more source

Reduced T Cell Priming in Microbially Experienced "Dirty" Mice Results from Limited IL-27 Production by XCR1+ Dendritic Cells.

Journal of Immunology, 2022
Successful vaccination strategies offer the potential for lifelong immunity against infectious diseases and cancer. There has been increased attention regarding the limited translation of some preclinical findings generated using specific pathogen-free ...
Frances V. Sjaastad, M. Huggins, Erin D. Lucas, Cara Skon-Hegg, W. Swanson, Matthew D Martin, Oscar C. Salgado, Julie Xu, Mark J Pierson, T. Dileepan, T. Kucaba, Sara E. Hamilton, T. Griffith   +12 more
semanticscholar   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Structural and functional divergence of growth hormone-releasing hormone receptors in early sarcopterygians: lungfish and Xenopus [PDF]

, 2013
The evolutionary trajectories of growth hormone-releasing hormone (GHRH) receptor remain enigmatic since the discovery of physiologically functional GHRH-GHRH receptor (GHRHR) in non-mammalian vertebrates in 2007.
Chow, BKC, Lee, TO, TAM, KV
core   +1 more source

Cytomegalovirus Expresses the Chemokine Homologue vXCL1 Capable of Attracting XCR1 ⁺ CD4 ⁻ Dendritic Cells [PDF]

Journal of Virology, 2014
ABSTRACT Cytomegaloviruses (CMV) have developed various strategies to escape the immune system of the host. One strategy involves the expression of virus-encoded chemokines to modulate the host chemokine network. We have identified in the English isolate of rat CMV (murid herpesvirus 8 [MuHV8]) an open reading frame encoding a ...
Geyer, Henriette, Hartung, Evelyn, Mages, Hans Werner, Weise, Christoph, Belužić, Robert, Vugrek, Oliver, Jonjić, Stipan, Kroczek, Richard, Voigt, Sebastian   +8 more
openaire   +5 more sources