Results 51 to 60 of about 3,980 (196)

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

open access: yesAdvanced Science, Volume 13, Issue 60, 28 October 2026.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li   +11 more
wiley   +1 more source

Deep Learning Predicts Hematopoietic Stem Cell Aging From 3D Chromatin Images

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
Deep learning identifies age‐associated chromatin architecture signatures in 3D images of hematopoietic stem cell nuclei, providing an interpretable imaging biomarker that distinguishes young from aged cells and detects chromatin rejuvenation after treatment.
Pablo Iáñez Picazo   +5 more
wiley   +1 more source

Association Study of TAF1 Variants in Parkinson’s Disease

open access: yesFrontiers in Neuroscience, 2022
Increasing evidence reveals sex as an important factor in the development of Parkinson’s disease (PD), but associations between genes on the sex chromosomes and PD remain unknown.
Qian Zeng   +18 more
doaj   +1 more source

High-Performance Software Load Balancer for Cloud-Native Architecture

open access: yesIEEE Access, 2021
Driven by increasing in the demand for cloud computing, cloud providers are constantly seeking configuration mechanisms designed to simply install a reliable and easy-to-manage cloud architecture—similar to installing an operating system on a ...
Jung-Bok Lee   +5 more
doaj   +1 more source

TAF1 as the Most Plausible Disease Gene for XDP/DYT3 [PDF]

open access: yesThe American Journal of Human Genetics, 2007
To the Editor: We address the concerns of Dr. Muller and his colleagues1(in this issue) regarding our recent article in the Journal.2 Previously, Muller et al. reported that five disease-specific single-nucleotide changes (DSCs) in a “multiple transcript system” (MTS) were associated with XDP (MIM #314250).3 Our article was the first to report TAF1 ...
Tamiya, Gen   +2 more
openaire   +1 more source

Moist Thermodynamic Processes Leading to the Onset of Moist Tropical Heat Waves

open access: yesGeophysical Research Letters, Volume 53, Issue 18, 28 September 2026.
Abstract The plume buoyancy framework used in previous work is applied to understand the processes that lead to moist tropical heat waves (HW). Lag composite analysis applied to land and ocean regions that often experience moist heat waves reveals that buoyancy is typically positive prior to the HW, becoming negative during HW onset due to an increase ...
Sofía A. Avila Nevarez   +1 more
wiley   +1 more source

Piroxicam Loading onto Mesoporous Silicas by Supercritical CO2 Impregnation

open access: yesMolecules, 2021
Piroxicam (PRX) is a commonly prescribed nonsteroidal anti-inflammatory drug. Its efficacy, however, is partially limited by its low water solubility. In recent years, different studies have tackled this problem and have suggested delivering PRX through ...
Marta Gallo   +6 more
doaj   +1 more source

The Growth Supporting Role of ZDHHC11 Is Linked to the MEF2B–BCL6 Regulatory Circuit in Burkitt Lymphoma

open access: yesInternational Journal of Cancer, Volume 159, Issue 6, Page 1535-1545, 15 September 2026.
MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier   +12 more
wiley   +1 more source

Pengujian Kinerja XDP sebagai Firewall Terhadap Serangan Denial of Service pada Web Server [PDF]

open access: yes
Penelitian ini bertujuan untuk mengevaluasi kinerja XDP, teknologi baru yang memanfaatkan eBPF untuk melakukan penyaringan paket secara efisien. Salah satu kemampuannya adalah mencegah serangan Denial of Service (DoS).
Susanto, Natanael Jeffrey
core   +1 more source

Single‐Cell Transcriptome of Anaplastic Thyroid Cancer Reveals Immunosuppressive Tumor Microenvironment Remodeling

open access: yesCancer Medicine, Volume 15, Issue 9, September 2026.
Single‐cell RNA sequencing of anaplastic thyroid cancer (ATC) and aggressive papillary thyroid cancer (PTC) revealed coordinated tumor‐intrinsic and immune reprogramming during thyroid cancer dedifferentiation. ATC exhibited MAPK/PI3K co‐activation, p53 suppression, E2F activation, cytotoxic lymphocyte exhaustion, enhanced regulatory T‐cell ...
Saeko Tahara   +6 more
wiley   +1 more source

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