Results 51 to 60 of about 3,980 (196)
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li +11 more
wiley +1 more source
Deep Learning Predicts Hematopoietic Stem Cell Aging From 3D Chromatin Images
Deep learning identifies age‐associated chromatin architecture signatures in 3D images of hematopoietic stem cell nuclei, providing an interpretable imaging biomarker that distinguishes young from aged cells and detects chromatin rejuvenation after treatment.
Pablo Iáñez Picazo +5 more
wiley +1 more source
Association Study of TAF1 Variants in Parkinson’s Disease
Increasing evidence reveals sex as an important factor in the development of Parkinson’s disease (PD), but associations between genes on the sex chromosomes and PD remain unknown.
Qian Zeng +18 more
doaj +1 more source
High-Performance Software Load Balancer for Cloud-Native Architecture
Driven by increasing in the demand for cloud computing, cloud providers are constantly seeking configuration mechanisms designed to simply install a reliable and easy-to-manage cloud architecture—similar to installing an operating system on a ...
Jung-Bok Lee +5 more
doaj +1 more source
TAF1 as the Most Plausible Disease Gene for XDP/DYT3 [PDF]
To the Editor: We address the concerns of Dr. Muller and his colleagues1(in this issue) regarding our recent article in the Journal.2 Previously, Muller et al. reported that five disease-specific single-nucleotide changes (DSCs) in a “multiple transcript system” (MTS) were associated with XDP (MIM #314250).3 Our article was the first to report TAF1 ...
Tamiya, Gen +2 more
openaire +1 more source
Moist Thermodynamic Processes Leading to the Onset of Moist Tropical Heat Waves
Abstract The plume buoyancy framework used in previous work is applied to understand the processes that lead to moist tropical heat waves (HW). Lag composite analysis applied to land and ocean regions that often experience moist heat waves reveals that buoyancy is typically positive prior to the HW, becoming negative during HW onset due to an increase ...
Sofía A. Avila Nevarez +1 more
wiley +1 more source
Piroxicam Loading onto Mesoporous Silicas by Supercritical CO2 Impregnation
Piroxicam (PRX) is a commonly prescribed nonsteroidal anti-inflammatory drug. Its efficacy, however, is partially limited by its low water solubility. In recent years, different studies have tackled this problem and have suggested delivering PRX through ...
Marta Gallo +6 more
doaj +1 more source
MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier +12 more
wiley +1 more source
Pengujian Kinerja XDP sebagai Firewall Terhadap Serangan Denial of Service pada Web Server [PDF]
Penelitian ini bertujuan untuk mengevaluasi kinerja XDP, teknologi baru yang memanfaatkan eBPF untuk melakukan penyaringan paket secara efisien. Salah satu kemampuannya adalah mencegah serangan Denial of Service (DoS).
Susanto, Natanael Jeffrey
core +1 more source
Single‐cell RNA sequencing of anaplastic thyroid cancer (ATC) and aggressive papillary thyroid cancer (PTC) revealed coordinated tumor‐intrinsic and immune reprogramming during thyroid cancer dedifferentiation. ATC exhibited MAPK/PI3K co‐activation, p53 suppression, E2F activation, cytotoxic lymphocyte exhaustion, enhanced regulatory T‐cell ...
Saeko Tahara +6 more
wiley +1 more source

