Results 61 to 70 of about 3,680 (196)

Importance of Mesoporous Silica Particle Size in the Stabilization of Amorphous Pharmaceuticals—The Case of Simvastatin

Pharmaceutics, 2020
In this paper, the role of mesoporous silica (MS) particle size in the stabilization of amorphous simvastatin (SVT) is revealed. For inhibiting recrystallization of the supercooled drug, the two MS materials (Syloid® XDP 3050 and Syloid® 244 FP) were ...
Justyna Knapik-Kowalczuk, Daniel Kramarczyk, Krzysztof Chmiel, Jana Romanova, Kohsaku Kawakami, Marian Paluch   +5 more
doaj   +1 more source

The Distribution of Complement Proteins in Soft and Hard Coronas Impacts Macrophage Uptake of Nanoparticles

Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.
Protein corona plays a critical role in the biological behavior of nanoparticles. This study investigates the distribution of complement proteins in soft corona and their impact on the macrophage uptake of polymer nanoparticles. It underlines the significance of soft corona investigation for understanding in vivo performance of nanomedicines.
Ying Qiu, Tianchang He, Chunjie Miao, Xinyang Shi, Yuanyuan Niu, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +8 more
wiley   +1 more source

Expression of CD38 on resting peripheral iNKT cells defines an immature subpopulation with distinct functionality in humans

Immunology &Cell Biology, Volume 104, Issue 2, Page 109-124, February 2026.
In this study, we characterize a distinct subpopulation of undifferentiated invariant natural killer T (iNKT) cells in the peripheral blood of healthy adults, which are characterized by CD38 expression in a resting state. This CD38+ subset closely resembles iNKT cells from cord blood and thymus, exhibiting a unique cytokine profile and alterations in ...
Christopher Menne, Naeimeh Tavakolinia, Louis Perriman, Wiebke Moskorz, Christine Cosmovici, Andreas Walker, Lara Olejnik, Katharina Raba, Mei RM Du, Fernando J Rossello, Igor E Konstantinov, Stuart P Berzins, Daniel G Pellicci, Jörg Timm   +13 more
wiley   +1 more source

Single‐Cell RNA‐Sequencing Reveals Cachectic Satellite Cell Population in Muscle of Male Mice With Cancer Cachexia

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cancer cachexia leads to decreases in body mass, lean mass and fat mass, decreased therapeutic potential and ~20% of cancer‐related deaths. While several studies have demonstrated changes to components of the muscle microenvironment with cancer cachexia, none have comprehensively assessed changes to cellular dynamics across the ...
Alex Brown, Nicolás Collao, Aisha Saleh, Natasha Strong, Michael De Lisio, Nadine Wiper‐Bergeron   +5 more
wiley   +1 more source

Elucidating Hexanucleotide Repeat Number and Methylation within the X-Linked Dystonia-Parkinsonism (XDP)-Related SVA Retrotransposon in TAF1 with Nanopore Sequencing

, 2022
Background: X-linked dystonia-parkinsonism (XDP) is an adult-onset neurodegenerative disorder characterized by progressive dystonia and parkinsonism.
Joshua Laβ, Roland Dominic G. Jamora, Norbert Brüggemann, Cid Czarina E. Diesta, Kathleen Schlüter, Susen Schaake, Theresa Lüth, Joanne Trinh, Max Brand, Hauke Busch, Charles Jourdan Reyes, Ana Westenberger, Ronnie Tse, Inken Wohlers, Christine Klein, Gerard Saranza, Jelena Pozojevic, Raymond L. Rosales   +17 more
core   +1 more source

Introducing SmartNICs in Server-Based Data Plane Processing: The DDoS Mitigation Use Case

IEEE Access, 2019
In the recent years, the complexity of the network data plane and their requirements in terms of agility has increased significantly, with many network functions now implemented in software and executed directly in datacenter servers.
Sebastiano Miano, Roberto Doriguzzi-Corin, Fulvio Risso, Domenico Siracusa, Raffaele Sommese   +4 more
doaj   +1 more source

SmartX Multi-Sec: A Visibility-Centric Multi-Tiered Security Framework for Multi-Site Cloud-Native Edge Clusters

IEEE Access, 2021
Recently, to match the emerging demands for multi-site edge clouds, the cloud-based information and communication technology (ICT) infrastructure is rapidly expanding.
Jun-Sik Shin, Jongwon Kim
doaj   +1 more source

Iron Deficiency Impairs Muscle Stem Cell Proliferation and Skeletal Muscle Regeneration via HIF‐2α Stabilization

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Functional iron deficiency affects a large proportion of patients with chronic diseases and is increasingly observed in older adults. Clinical evidence links iron deficiency to sarcopenia, yet the mechanistic relationship between iron status and muscle regeneration remains poorly defined.
Wenyan Fu, Yang Liu, Amelia Yin, Liwei Xie, Hang Yin   +4 more
wiley   +1 more source

Enhancing the dissolution of phenylbutazone using Syloid® based mesoporous silicas for oral equine applications

Journal of Pharmaceutical Analysis, 2018
Three mesoporous silica excipients (Syloid® silicas AL-1 FP, XDP 3050 and XDP 3150) were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent and rate of drug dissolution. Although
Laura J. Waters, John P. Hanrahan, Joseph M. Tobin, Catherine V. Finch, Gareth M.B. Parkes, Shamsuddeen A. Ahmad, Faraj Mohammad, Maria Saleem   +7 more
doaj   +1 more source

Strain‐Adaptive Liquid Metal Interfaces Overcome Poisson's Ratio Constraints in Piezoresistive Sensors for Infant Sleep Monitoring

Advanced Science, Volume 12, Issue 44, November 27, 2025.
 This work overcomes Poisson's ratio limitations in piezoresistive sensors via strain‐adaptive liquid metal (LM) interfaces. EGaIn‐coated TPU scaffolds enable directional LM flow to fill microcracks under deformation, achieving ultra‐high sensitivity (693.65 kPa-1).
Yuxiao Zhang, Chenchen Wang, Juan Tao, Shaoyu Ma, Siyu Xie, Weiwei Guo, Rongrong Bao, Jianbei Qiu, Yue Liu, Zhengwen Yang, Caofeng Pan   +10 more
wiley   +1 more source