Results 111 to 120 of about 67,145 (262)

Competitive elimination of ZO-1/ZO-2-deficient cells regulates epithelial barrier homeostasis

SummaryEpithelia cover the body and form a barrier to segregate the internal body from the external environment. Epithelial tissues contact the external environment and are exposed to various stresses that are potentially deleterious for the epithelial barrier1.
Tetsuhisa Otani, Thanh Phuong Nguyen, Noriyuki Kinoshita, Toshihiko Fujimori, Mikio Furuse   +4 more
openaire   +1 more source

Static black hole solutions with a self interacting conformally coupled scalar field

, 2008
We study static, spherically symmetric black hole solutions of the Einstein equations with a positive cosmological constant and a conformally coupled self interacting scalar field.
Cristián Martínez, Gustavo Dotti, K. A. Bronnikov, N. Bocharova, R. Ruffini, Reinaldo J. Gleiser   +5 more
core   +1 more source

Nanotherapeutic Macrophage‐Neuro Reprogramming Through Immunometabolic Crosstalk Mitigates Sepsis‐Induced Lung Injury and Neurologic Damage

Advanced Science, EarlyView.
SJNPs co‐deliver JHU083 and spermine to reprogram macrophage–neuron immunometabolic crosstalk in sepsis. By suppressing pro‐inflammatory M1 polarization and promoting NGF‐mediated neurotrophic signaling, SJNPs preserve pulmonary neuronal integrity, alleviate lung injury, and improve survival in murine sepsis models.
Wenhui Wang, Yongrui Hai, Xintong Lu, Ye Chen, Bingjie Zhang, Renming Fan, Jiarui Dou, Jiaxin Yan, Shuo Fu, Wen Zhang, Junke Song, Gaofei Wei   +11 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Expression and Clinical Significance of ZO-1 in Patients with Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2011
Background and objective It has been proven that the expression of ZO-1 (zonula occluden-1) was correlated with the growth and metastasis of cancer.
Yekai WANG, Jihang ZHOU, Fang ZENG, Yanyan HUANG, Shiquan ZHOU, Xiaoguang LIU   +5 more
doaj  

Tight junction protein changes in irritable bowel syndrome: the relation of age and disease severity [PDF]

The Korean Journal of Internal Medicine
Background/Aims The etiology of irritable bowel syndrome (IBS) is associated with intestinal mucosal barrier damage. However, changes in the tight junction (TJ) proteins in IBS have not been fully elucidated.
Sang Un Kim, Ji A Choi, Man-Hoon Han, Jin Young Choi, Ji Hye Park, Moon Sik Kim, Yong Hwan Kwon   +6 more
doaj   +1 more source

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats

Frontiers in Physiology, 2018
The aim of this study was to investigate if urinary glutamyl aminopeptidase (GluAp), alanyl aminopeptidase (AlaAp), Klotho and hydroxyproline can be considered as potential biomarkers of renal injury and fibrosis in an experimental model of obesity. Male
Sebastián Montoro-Molina, Antonio López-Carmona, Andrés Quesada, Francisco O’Valle, Francisco O’Valle, Natividad Martín-Morales, Antonio Osuna, Antonio Osuna, Félix Vargas, Félix Vargas, Rosemary Wangensteen   +10 more
doaj   +1 more source

Electric Control of Spin Currents and Spin-Wave Logic

, 2011
Spin waves in insulating magnets are ideal carriers for spin currents with low energy dissipation. An electric field can modify the dispersion of spin waves, by directly affecting, via spin-orbit coupling, the electrons that mediate the interaction ...
D. C. Mattis, E. M. Liftshitz, G. Vignale, Tianyu Liu   +3 more
core   +1 more source

A Cascade Recognition of Activatable Probe for Fluorescence Navigation Glioblastoma Surgery: Overcoming Blood‐Brain Barrier and Off‐Target Limitations

Advanced Science, EarlyView.
A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An, Yu Guo, Yongning Bian, Yanli Tan, Chuan Fang, Hengzhu Zhang, Xueqian Chen, Lin Yuan, Dongdong Su   +8 more
wiley   +1 more source