Results 1 to 10 of about 31,457 (207)

Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions [PDF]

Nature Communications, 2016
Alcohol abuse is a risk factor for acute respiratory distress syndrome, flooding of the lungs due to compromised barrier function. Here the authors report that alcohol upregulates claudin-5 that is then recruited to tight junctions in alveolar epithelial
Barbara Schlingmann, Christian E. Overgaard, Samuel A. Molina, K. Sabrina Lynn, Leslie A. Mitchell, StevenClaude Dorsainvil White, Alexa L. Mattheyses, David M. Guidot, Christopher T. Capaldo, Michael Koval   +9 more
doaj   +5 more sources

Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients [PDF]

PeerJ, 2022
Allergic rhinitis (AR) is a common allergic disease characterized by disruption of nasal epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 (ZO-1), ZO-2 and ZO-3 and histone deacetylase 1 (HDAC1) and HDAC2 in AR ...
Che Othman Siti Sarah, Siti Muhamad Nur Husna, Norasnieda Md. Shukri, Kah Keng Wong, Noor Suryani Mohd Ashari   +4 more
doaj   +5 more sources

27-Hydroxycholesterol induces expression of zonula occludens-1 in monocytic cells via multiple kinases pathways [PDF]

Scientific Reports, 2022
Zonula occludens (ZO)-1, a tight-junction protein (TJP), is expressed in dendritic cells (DCs) but not in monocytes, and 27-hydroxycholesterol (27OHChol) drives the differentiation of monocytes into DCs.
Hyok-rae Cho, Bo-Young Kim, Koanhoi Kim, Dongjun Lee, Seong-Kug Eo, Yonghae Son   +5 more
doaj   +5 more sources

Protects Porcine Intestinal Barrier from Deoxynivalenol via Improved Zonula Occludens-1 Expression [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
Intestinal epithelial cells (IECs) forming the barrier for the first-line of protection are interconnected by tight junction (TJ) proteins. TJ alteration results in impaired barrier function, which causes potentially excessive inflammation leading to ...
Min Jeong Gu, Sun Kwang Song, Sung Moo Park, In Kyu Lee, Cheol-Heui Yun   +4 more
doaj   +6 more sources

Calcitonin Receptor-Zonula Occludens-1 Interaction Is Critical for Calcitonin-Stimulated Prostate Cancer Metastasis. [PDF]

PLoS ONE, 2016
The role of neuroendocrine peptide calcitonin (CT) and its receptor (CTR) in epithelial cancer progression is an emerging concept with great clinical potential.
Ahmed Aljameeli, Arvind Thakkar, Shibu Thomas, Vijaybasker Lakshmikanthan, Kenneth A Iczkowski, Girish V Shah   +5 more
doaj   +7 more sources

Altered Expression of Zonula occludens-1 Affects Cardiac Na⁺ Channels and Increases Susceptibility to Ventricular Arrhythmias [PDF]

Cells, 2022
Zonula occludens-1 (ZO-1) is an intracellular scaffolding protein that orchestrates the anchoring of membrane proteins to the cytoskeleton in epithelial and specialized tissue including the heart.
Mona El Refaey, Sara Coles, Hassan Musa, Tyler L. Stevens, Michael J. Wallace, Nathaniel P. Murphy, Steve Antwi-Boasiako, Lindsay J. Young, Heather R. Manring, Jerry Curran, Michael A. Makara, Kelli Sas, Mei Han, Sara N. Koenig, Michel Skaf, Crystal F. Kline, Paul M. L. Janssen, Federica Accornero, Maegen A. Borzok, Peter J. Mohler   +19 more
doaj   +2 more sources

Serum Zonula Occludens-1 and Claudin-5 Levels in Patients with Insomnia Disorder: A Pilot Study [PDF]

Nature and Science of Sleep, 2023
Mei Fan, Fangyi Deng, Rui Tang, Yixian Cai, Xiaotao Zhang, Hongyao Li, Ting Xiang, Jiyang Pan Department of Psychiatry, Sleep Medicine Centre, The First Affiliated Hospital, Jinan University, Guangzhou, People’s Republic of ChinaCorrespondence: Jiyang ...
Fan M, Deng F, Tang R, Cai Y, Zhang X, Li H, Xiang T, Pan J   +7 more
doaj   +2 more sources

Increased systemic zonula occludens 1 associated with inflammation and independent biomarker in patients with hepatocellular carcinoma [PDF]

BMC Cancer, 2018
Background Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have shown evidence that tight junction (
Amit Kumar Ram, Biju Pottakat, Balasubramaniyan Vairappan   +2 more
doaj   +2 more sources

Rickettsia disrupts and reduces endothelial tight junction protein zonula occludens-1 in association with inflammasome activation [PDF]

Infection and Immunity
Rickettsia spp. cause life-threatening diseases in humans. The fundamental pathophysiological changes in fatal rickettsial diseases are disrupted endothelial barrier and increased microvascular permeability.
Loka Reddy Velatooru, Esteban Arroyave, Meagan D. Rippee-Brooks, Megan Burch, Ethan Yang, Bing Zhu, David H. Walker, Yang Zhang, Rong Fang   +8 more
doaj   +2 more sources

Tight junctions expression is affected by active, inactive, and derivatives of Akkermansia muciniphila [PDF]

Iranian Journal of Microbiology
Background and Objectives: Tight junctions (TJs) in the gastrointestinal tract are comprised of various junctional proteins including Occludin and Zonula Occludens (ZO-1) that have a critical role in epithelial barrier function. Gut microbiota and their
Farinaz Ghaderi, Zahra Hajebrahimi, Abolfazl Fateh, Fattah Sotoodehnejadnematalahi, Sara Ahmadi Badi, Somayeh Vaezijoze, Seyed Davar Siadat   +6 more
doaj   +2 more sources