Results 91 to 100 of about 27,806 (225)

The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice. [PDF]

, 2018
Zinc (Zn2+) is a pleiotropic modulator of the neuronal and brain activity. The disruption of intraneuronal Zn2+ levels triggers neurotoxic processes and affects neuronal functioning.
Bomba, Manuela, Castelli, Vanessa, Castelli, Vanessa, Cimini, Annamaria, d'Aurora, Marco, Delli Pizzi, Stefano, Frazzini, Valerio, Gatta, Valentina, Granzotto, Alberto, Iorio, Mariangela, Massetti, Noemi, Mosca, Alessandra, Punzi, Miriam, Sensi, Stefano L   +13 more
core   +3 more sources

CD8+ T Cells Negatively Modulate Ischemia‐Induced Angiogenesis in Mice

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
Graphical illustration of the mechanism of CD8+ T‐cells/IFN‐γ axis‐mediated angiogenesis in response to ischemic stress. CD8+ T‐cell functions as an important mediator of ischemia‐induced angiogenesis via the modulation of inflammation, oxidative stress, proteolysis, and endothelial proliferation that might be mediated by the IFN‐γ/NLRp3‐caspase‐1 and ...
Xianji Piao, Jin Jingyuan, Longzhu Dai, Longguo Zhao, Yanglong Li, Megumi Narisawa, Shangzhi Shu, Yanna Lei, Xueling Yue, Jinshun Piao, Chengjie Zhu, Lina Hu, Qingsong Cui, Xian Wu Cheng   +13 more
wiley   +1 more source

Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation [PDF]

, 2011
Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.
Hwang, Jae-woong, Rahman, Irfan, Sun, Jun, Sundar, Isaac K, Wu, Shaoping   +4 more
core   +1 more source

Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke

Brain Pathology, Volume 35, Issue 6, November 2025.
After ischemic stroke, TRPV4 activation induces cerebral edema through the TRPV4‐RhoA‐MMP9 axis: RhoA upregulates MMP9, which cleaves β‐DG to impair membrane anchoring. Subsequent β‐DG loss triggers AQP4 depolarization, disrupting GS‐mediated water homeostasis.
Yongchuan Li, Haiping Zhou, Jiaxin Xie, Mingjia Yu, Guanyu Ye, Yuzhen Zhang, Zhentong Li, Kunxue Zhang, Jingwen Wu, Sheng Xiao, Shuxin Zeng, Yuan Chang, Kaibin Huang, Suyue Pan   +13 more
wiley   +1 more source

Matrix metalloproteinases 2 and 9 in rabbits with doxorubicin-induced cardiomyopathy

Pesquisa Veterinária Brasileira
: Some studies have shown the role played by matrix metalloproteinases and their inhibitors in doxorubicin cardiotoxicity. In this study, we sought to investigate how plasma and myocardial MMP 2 and 9 perform in rabbits with doxorubicin-induced ...
Sheila S.S. Nogueira, Marlos G. Sousa, Fabio N. Gava, Fernando A. Rosa, Guilherme D. Melo, Gustavo Dittrich, Gisele F. Machado, Aparecido A. Camacho   +7 more
doaj   +1 more source

Endolysin Expression, Purification and Activity Determination by Zymography

Bio-Protocol, 2014
Endolysins are peptidoglycan-degrading (muralytic) enzymes produced by many bacteriophages for cell lysis of the host bacterium. The enzymatic activity of muralytic enzymes can be assayed qualitatively using a zymogram containing incorporated ...
Alexander Westbye, Paul Fogg, John Beatty   +2 more
doaj   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Dynamic changes of mmp-9 plasma levels correlate with jvc reactivation and immune activation in natalizumab-treated multiple sclerosis patients [PDF]

, 2019
The aim of the study was to investigate the changes of matrix metalloproteinase (MMP)-2 and MMP-9 plasma levels during natalizumab treatment and their correlation with JC virus (JCV) reactivation and T-lymphocyte phenotypic modifications in peripheral ...
Ciardi, Maria Rosa, Cortese, Antonio, D’Agostino, Claudia, Francia, Ada, Frontoni, Marco, Iannetta, Marco, Latronico, Tiziana, Liuzzi, Grazia Maria, Mastroianni, Claudio Maria, Pati, Ilaria, Pietropaolo, Valeria, Pontecorvo, Simona, Prezioso, Carla, Vullo, Vincenzo, Zingaropoli, Maria Antonella   +14 more
core   +3 more sources

Sulfur mustard-stimulated proteases and their inhibitors in a cultured normal human epidermal keratinocytes model: A potential approach for anti-vesicant drug development

Toxicology Reports, 2016
Protease stimulation in cultured normal human epidermal keratinocytes (NHEK) due to sulfur mustard (SM) exposure is well documented. However, the specific protease(s) stimulated by SM and the protease substrates remain to be determined. In this study, we
Xiannu Jin, Radharaman Ray, Prabhati Ray
doaj   +1 more source

Assessment and partial purification of serine protease inhibitors from Rhipicephalus (Boophilus) annulatuslarvae

Revista Brasileira de Parasitologia Veterinária
Ticks are rich sources of serine protease inhibitors, particularly those that prevent blood clotting and inflammatory responses during blood feeding. The tick Rhipicephalus (Boophlus) annulatusis an important ectoparasite of cattle.
Sedigheh Nabian, Mohammad Taheri, Mohammad Mehdi Ranjbar, Alireza Sazmand, Parastou Youssefy, Gholam Reza Nazaralipour   +5 more
doaj   +1 more source