Results 81 to 90 of about 26,894 (230)

M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes. [PDF]

, 2017
Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults.
Bai, Li, Chen, Yu, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Kong, Ming, Liu, Shuang, Liu, Xin, Lou, Jinli, Pandol, Stephen J, Ren, Feng, Zhang, Xiaohui, Zheng, Qingfen, Zheng, Sujun   +13 more
core   +2 more sources

Hyperoside Modulates the Estrogen‐PI3K/VEGF Axis to Ameliorate Oxidative Damage‐Induced Inhibition of Bone Formation in MC3T3‐E1 Cells

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
This study explores the potential of hyperoside to activate the estrogen‐PI3K/VEGF axis, thereby suppressing oxidative stress and enhancing osteogenic differentiation to mitigate osteoporosis. The initial proposal of the estrogen‐PI3K/VEGF signaling pathway axis as a potential therapeutic approach for osteoporosis.
Shuo Wang, Wei Feng, Xueqin Feng, Peitong Wu, Nanxi Zhang, Xiaoqian Yang, Yawen Li, Chunnan Li, Jiaming Sun   +8 more
wiley   +1 more source

Cobalt‐Doped Biphasic Calcium Phosphate Orchestrates Osteogenesis‐Angiogenesis Signals via Hypoxia‐Mimetic Signaling

Journal of Biomedical Materials Research Part A, Volume 114, Issue 4, April 2026.
ABSTRACT We engineered a cobalt‐doped biphasic calcium phosphate (CoBCP) by combining monetite‐derived pyrophosphate and β‐tricalcium phosphate (β‐TCP) with lattice‐incorporated Co2+, and evaluated its physicochemical profile and in vitro bioactivity relevant to bone regeneration.
Luísa Camilo Suter, Gerson Santos de Almeida, Matheus Luquirini Penteado dos Santos, Maria Gabriela Jacheto Carra, Marcel Rodrigues Ferreira, Margarida Juri Saeki, Willian Fernando Zambuzzi   +6 more
wiley   +1 more source

Guaiacol peroxidase zymography for the undergraduate laboratory [PDF]

Biochemistry and Molecular Biology Education, 2014
AbstractThis laboratory exercise presents a novel way to introduce undergraduate students to the specific detection of enzymatic activity by electrophoresis. First, students prepare a crude peroxidase extract and then analyze the homogenate via electrophoresis.
Jeff, Wilkesman, Diana, Castro, Lellys M, Contreras, Liliana, Kurz   +3 more
openaire   +2 more sources

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma [PDF]

, 2016
Indexación: Web of ScienceBackground: Class I histone deacetylases (HDACs) have been reported to be overexpressed in clear cell renal cell carcinoma (ccRCC), whereas the expression of class II HDACs is unknown.
Attwood, Kris, Chintala, Sreenivasulu, Ciamporcero, Eric, Conroy, Dylan, Das, Gokul, Ellis, Leigh, Huang, Ray, Ku, ShengYu, Miles, Kiersten Marie, Orillion, Ashley, Pili, Roberto, Ramakrishnan, Swathi, Shen, Li, Sotomayor, Paula, Swetzig, Wendy   +14 more
core   +2 more sources

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Vibrio proteases for biomedical applications: Modulating the proteolytic secretome of v. alginolyticus and v. parahaemolyticus for improved enzymes production [PDF]

, 2019
Proteolytic enzymes are of great interest for biotechnological purposes, and their large-scale production, as well as the discovery of strains producing new molecules, is a relevant issue.
Ghersi G., Nicosia A., Salamone M., Tagliavia M.   +3 more
core   +1 more source

Towards a Novel Biocontrol Strategy: High Performance of Optimised Cell Wall‐Degrading Enzymes Secreted by Escovopsis primorosea LBM 277

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Escovopsis primorosea LBM 277 efficiently produced proteases, β‐1,3‐glucanases and chitinases under submerged fermentation using Leucoagaricus gongylophorus cell walls and Mandels complex. RSM‐BBD optimization significantly increased enzyme activity. The enzymatic cocktail remained stable for 30 days at room temperature and pH 4–6, aligning with the ...
Marcela Paola Barengo, Natalia Soledad Amerio, Gustavo Ángel Bich, Pedro Darío Zapata, María Lorena Castrillo   +4 more
wiley   +1 more source

An improved collagen zymography approach for evaluating the collagenases MMP-1, MMP-8, and MMP-13

BioTechniques, 2017
Collagen zymography is an SDS-PAGE–based method for detecting both the proenzyme and active forms of collagenases. Although collagen zymography is used for assessment of the matrix metalloproteinases MMP-1 and MMP-13, it can be difficult to detect these ...
Seniz Inanc, Didem Keles, Gulgun Oktay
doaj   +1 more source

Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer [PDF]

, 2011
Background Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing specific cathepsin activity in complex tissue extracts confounds scientific studies
Binbin Chen, Manu O Platt
core   +4 more sources