Results 1 to 10 of about 1,207 (118)

Discovery of New α-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation

Frontiers in Chemistry, 2021
α-Glycosidase inhibitors could inhibit the digestion of carbohydrates into glucose and promote glucose conversion, which have been used for the treatment of type 2 diabetes.
Shan-Kui Liu, Haifang Hao, Yuan Bian, Yong-Xi Ge, Shengyuan Lu, Hong-Xu Xie, Kai-Ming Wang, Hongrui Tao, Chao Yuan, Juan Zhang, Jie Zhang, Cheng-Shi Jiang, Kongkai Zhu, Kongkai Zhu   +13 more
doaj   +1 more source

Digestive glycosidases from cannonball jellyfish (Stomolophus sp. 2): identification and temporal-spatial variability [PDF]

PeerJ, 2023
Jellyfish are economically important organisms in diverse countries, carnivorous organisms that consume various prey (crustaceans, mollusks, bivalves, etc.) and dissolved carbohydrates in marine waters. This study was focused on detecting and quantifying
Raul Balam Martinez-Perez, Jorge A. Rodriguez, Miguel A. Cisneros-Mata, Luis Alonso Leyva Soto, Pablo Gortáres-Moroyoqui, Ana Renteria-Mexia, Edna Abigail Hernandez Corral, Lourdes M. Diaz-Tenorio   +7 more
doaj   +2 more sources

Some old 2-(4-(Aryl)- thiazole-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-tethanoisoindole-1,3(2H)-dione derivatives: Synthesis, inhibition effects and molecular docking studies on Aldose reductase and α-Glycosidase

Cumhuriyet Science Journal, 2021
Utilizing the simple chromatic techniques, Aldose reductase (AR) was derived from sheep liver. In addition, α-glycosidase from Saccharomyces cerevisiae was used as the enzyme.
Burak Tüzün, Mustafa Ceylan, Parham Taslımı, Yeliz Demir, Hatice Esra Duran, Ümit Muhammet Koçyiğit, Osman Nuri Aslan, İlhami Gülçin   +7 more
doaj   +1 more source

Structure and function of proteins of the phosphotransferase system and of 6-phospho-β-glycosidases in Gram-positive bacteria [PDF]

FEMS Microbiology Reviews, 1993
New information about the proteins of the phosphotransferase system (PTS) and of phosphoglycosidases of homofermentative lactic acid bacteria and related species is presented. Tertiary structures were elucidated from soluble PTS components. They help to understand regulatory processes and PTS function in lactic acid bacteria.
Hengstenberg, W., Kohlbrecher, D., Witt, E., Kruse, R., Christiansen, I., Peters, D., von Strandmann, R., Städtler, P., Koch, B., Kalbitzer, H.   +9 more
openaire   +3 more sources

Water Caltrop (Trapa quadrispinosa Roxb.) Husk Improves Oxidative Stress and Postprandial Blood Glucose in Diabetes: Phenolic Profiles, Antioxidant Activities and α-Glycosidase Inhibition of Different Fractions with In Vitro and In Silico Analyses

Antioxidants, 2022
The aim of this study was to investigate the phenolic profiles, antioxidant activities and α-glycosidase inhibitory activities of three different phenolic fractions from water caltrop (Trapa quadrispinosa Roxb.) husk and to further explore the ...
Yuanyue Zhang, Shengbao Cai, Shuang Ma, Shuai Zhao, Junjie Yi, Linyan Zhou   +5 more
doaj   +1 more source

Quinoline- and Isoindoline-Integrated Polycyclic Compounds as Antioxidant, and Antidiabetic Agents Targeting the Dual Inhibition of α-Glycosidase and α-Amylase Enzymes

Pharmaceuticals, 2023
Novel analogs of quinoline and isoindoline containing various heterocycles, such as tetrazole, triazole, pyrazole, and pyridine, were synthesized and characterized using FT-IR, NMR, and mass spectroscopy, and their antioxidant and antidiabetic activities
Mohammed Al-Ghorbani, Osama Alharbi, Abdel-Basit Al-Odayni, Naaser A. Y. Abduh   +3 more
doaj   +1 more source

Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review

Frontiers in Microbiology, 2022
α-Glucosidase and α-amylase are the two main glycosidases that participate in the metabolism of carbohydrates. Inhibitors of these two enzymes are considered an important medical treatment for carbohydrate uptake disorders, such as diabetes and obesity ...
Xiaojing Wang, Xiaojing Wang, Xiaojing Wang, Jiaying Li, Jiaying Li, Jiaqi Shang, Jiaqi Shang, Jing Bai, Kai Wu, Kai Wu, Jing Liu, Jing Liu, Zhijun Yang, Zhijun Yang, Hao Ou, Lei Shao, Lei Shao   +16 more
doaj   +1 more source

Evaluation of antidiabetic effects, antioxidant activities, and phytochemical components of oleo-gum resins from three Iranian plants [PDF]

شیمی کاربردی روز, 2023
Ferula latisecta, Dorema kopetdaghense, and Dorema ammoniacum oleo-gum resins are among the most valuable Iranian herbal products and have great potential to be exported abroad.
Seyedeh Maryam Seyednezhad, Hossein Dehghan, Mostafa Fazli   +2 more
doaj   +1 more source

Advances in the synthesis of Homochiral (-)-1-azafagomine and (+)-5-epi-1-azafagomine. 1-N-phenyl carboxamide derivatives of both enantiomers of 1-azafagomine: leads for the synthesis of active α-Glycosidase inhibitors [PDF]

, 2011
- A new expeditious preparation of homochiral (-)-1-azafagomine, and (+)-5-epi-1-azafagomine has been devised. Stoodley´s diastereoselective cycloaddition of dienes bearing a 2,3,4,6-tetraacetyl glucosyl chiral auxiliary to 4-phenyl-1,2,4-triazole-3,5 ...
Alves, M. José, Costa, Flora Teixeira e, Duarte, Vera C. M., Fortes, A. Gil, Martins, J. A. R., Micaelo, N. M.   +5 more
core   +1 more source

Antidiabetic Potential: Effect of Resorcinol on α-Glycosidase and α-Amylase Enzymes

Cumhuriyet Science Journal, 2018
The vast majority of the carbohydrates in the biomolecule class areformed by photosynthesis using sunlight. One of the important enzymes in thisclass is α-glycosidase. This enzyme converts complex carbohydrates tomonosaccharides.
Fevzi Topal
doaj   +1 more source