Results 11 to 20 of about 35,992 (209)

Nano-Strategies Targeting the Integrin αvβ3 Network for Cancer Therapy

Cells, 2021
Integrin αvβ3, a cell surface receptor, participates in signaling transduction pathways in cancer cell proliferation and metastasis. Several ligands bind to integrin αvβ3 to regulate proliferation and metastasis in cancer cells.
Tsai-Mu Cheng, Wong-Jin Chang, Hsiu-Yi Chu, Roberto De Luca, Jens Z. Pedersen, Sandra Incerpi, Zi-Lin Li, Ya-Jung Shih, Hung-Yun Lin, Kuan Wang, Jacqueline Whang-Peng   +10 more
doaj   +1 more source

c-Abl Kinase Is a Regulator of αvβ3 Integrin Mediated Melanoma A375 Cell Migration. [PDF]

PLoS ONE, 2013
Integrins are heterodimeric transmembrane receptors that physically link the extracellular matrix (ECM) to the intracellular actin cytoskeleton, and are also signaling molecules that transduce signals bi-directionally across the plasma membrane. Integrin
Chunmei Zhang, Chao Yang, Ruifei Wang, Yang Jiao, Khamal Kwesi Ampah, Xiaoguang Wang, Xianlu Zeng   +6 more
doaj   +1 more source

Cancer Cell Gene Expression Modulated from Plasma Membrane Integrin αvβ3 by Thyroid Hormone and Nanoparticulate Tetrac [PDF]

Frontiers in Endocrinology, 2015
Integrin αvβ3 is generously expressed by cancer cells and rapidly dividing endothelial cells. The principal ligands of the integrin are extracellular matrix proteins, but we have described a cell surface small molecule receptor on αvβ3 that specifically binds thyroid hormone and thyroid hormone analogs. From this receptor, thyroid hormone (l-thyroxine,
Davis, PJ, Glinsky, GV, Lin, HY, Leith, JT, Hercbergs, A, Tang, HY, Ashur Fabian, O, INCERPI, Sandra, Mousa, SA   +8 more
openaire   +4 more sources

Inhibition of Integrin αvβ3-FAK-MAPK signaling constrains the invasion of T-ALL cells

Cell Adhesion & Migration, 2023
The role of adhesion receptor integrin αvβ3 in T-ALL was unclear. Firstly, we performed quantitative real-time PCR to assess medullary expression of integrin β3(ITGB3) in T-ALL patients and high ITGB3 expression was relevant with the central nervous ...
Lan Huang, Yao Zhu, Qinglin Kong, Xianmin Guan, Xiaoying Lei, Luying Zhang, Hui Yang, Xinyuan Yao, Shaoyan Liang, Xizhou An, Jie Yu   +10 more
doaj   +1 more source

The challenges and opportunities of αvβ3-based therapeutics in cancer: From bench to clinical trials

Pharmacological Research, 2023
Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals between cells and their environment.
Yanlun Gu, Bingqi Dong, Xu He, Zhiwei Qiu, Juqi Zhang, Mo Zhang, Haitao Liu, Xiaocong Pang, Yimin Cui   +8 more
doaj   +1 more source

Matrix metalloproteinase-2 promotes αvβ3 integrin-mediated adhesion and migration of human melanoma cells by cleaving fibronectin. [PDF]

PLoS ONE, 2012
BACKGROUND: Matrix metalloproteinase-2 (MMP-2) is a key regulator in the migration of tumor cells. αvβ3 integrin has been reported to play a critical role in cell adhesion and regulate the migration of tumor cells by promoting MMP-2 activation.
Yang Jiao, Xue Feng, Yinpeng Zhan, Ruifei Wang, Sheng Zheng, Wenguang Liu, Xianlu Zeng   +6 more
doaj   +1 more source

Inhibition by Thyroid Hormones of Cell Migration Activated by IGF-1 and MCP-1 in THP-1 Monocytes: Focus on Signal Transduction Events Proximal to Integrin αvβ3

Frontiers in Cell and Developmental Biology, 2021
Interaction between thyroid hormones and the immune system is reported in the literature. Thyroid hormones, thyroxine, T4, but also T3, act non-genomically through mechanisms that involve a plasma membrane receptor αvβ3 integrin, a co-receptor for ...
Elena Candelotti, Roberto De Luca, Roberto Megna, Mariangela Maiolo, Paolo De Vito, Fabio Gionfra, Zulema Antonia Percario, Monica Borgatti, Roberto Gambari, Paul J. Davis, Paul J. Davis, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Fabio Polticelli, Tiziana Persichini, Marco Colasanti, Elisabetta Affabris, Jens Z. Pedersen, Sandra Incerpi   +21 more
doaj   +1 more source

Regulation of the integrin αVβ3- actin filaments axis in early osteogenesis of human fibroblasts under cyclic tensile stress

Stem Cell Research & Therapy, 2021
Background Integrins play a prominent role in osteogenic differentiation by transmitting both mechanical and chemical signals. Integrin expression is closely associated with tensile stress, which has a positive effect on osteogenic differentiation.
Yan Peng, Rongmei Qu, Yanting Feng, Xiaolan Huang, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Jingxing Dai, Jun Ouyang   +10 more
doaj   +1 more source

Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression.

PLoS ONE, 2021
Neuroendocrine prostate cancer (NEPrCa) arises de novo or after accumulation of genomic alterations in pre-existing adenocarcinoma tumors in response to androgen deprivation therapies.
Fabio Quaglia, Shiv Ram Krishn, Yanqing Wang, David W Goodrich, Peter McCue, Andrew V Kossenkov, Amy C Mandigo, Karen E Knudsen, Paul H Weinreb, Eva Corey, William K Kelly, Lucia R Languino   +11 more
doaj   +1 more source

The epithelial αvβ3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components. [PDF]

PLoS Pathogens, 2014
TLR2 is a cell surface receptor which elicits an immediate response to a wide repertoire of bacteria and viruses. Its response is usually thought to be proinflammatory rather than an antiviral.
Tatiana Gianni, Gabriella Campadelli-Fiume   +1 more
doaj   +1 more source