Multimodality tumor imaging targeting integrin αvβ3 [PDF]
BioTechniques, 2005 The cell adhesion molecule integrin αvβ3 is an important player in the process of tumor angiogenesis and metastasis. Antibodies, peptides, peptidomimetics, and small molecule antagonists against integrin αvβ3 have been shown to induce endothelial ...
Weibo Cai +2 more
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Inhibition of Integrin αvβ3-FAK-MAPK signaling constrains the invasion of T-ALL cells [PDF]
Cell Adhesion & Migration, 2023 The role of adhesion receptor integrin αvβ3 in T-ALL was unclear. Firstly, we performed quantitative real-time PCR to assess medullary expression of integrin β3(ITGB3) in T-ALL patients and high ITGB3 expression was relevant with the central nervous ...
Lan Huang +10 more
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Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis [PDF]
BMC Biology, 2018 Background Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2 ...
Tomer Shlamkovich +4 more
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Integrin αVβ3 Function Influences Citalopram Immobility Behavior in the Tail Suspension Test [PDF]
Frontiers in Neuroscience, 2019 Human studies first identified genetic and expression interactions between integrin β3 and serotonin (5-HT) transporter (SERT) genes. This association has been further strengthened by our discovery that integrin β3-containing receptors (αvβ3) physically ...
Hope Pan +3 more
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Cancer Cell Gene Expression Modulated from Plasma Membrane Integrin αvβ3 by Thyroid Hormone and Nanoparticulate Tetrac [PDF]
Frontiers in Endocrinology, 2015 Integrin αvβ3 is generously expressed by cancer cells and rapidly dividing endothelial cells. The principal ligands of the integrin are extracellular matrix proteins, but we have described a cell surface small molecule receptor on αvβ3 that specifically binds thyroid hormone and thyroid hormone analogs. From this receptor, thyroid hormone (l-thyroxine,
Davis, PJ +8 more
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The challenges and opportunities of αvβ3-based therapeutics in cancer: From bench to clinical trials
Pharmacological Research, 2023 Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals between cells and their environment.
Yanlun Gu +8 more
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Matrix metalloproteinase-2 promotes αvβ3 integrin-mediated adhesion and migration of human melanoma cells by cleaving fibronectin. [PDF]
PLoS ONE, 2012 BACKGROUND: Matrix metalloproteinase-2 (MMP-2) is a key regulator in the migration of tumor cells. αvβ3 integrin has been reported to play a critical role in cell adhesion and regulate the migration of tumor cells by promoting MMP-2 activation.
Yang Jiao +6 more
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Frontiers in Cell and Developmental Biology, 2021 Interaction between thyroid hormones and the immune system is reported in the literature. Thyroid hormones, thyroxine, T4, but also T3, act non-genomically through mechanisms that involve a plasma membrane receptor αvβ3 integrin, a co-receptor for ...
Elena Candelotti +21 more
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The epithelial αvβ3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components. [PDF]
PLoS Pathogens, 2014 TLR2 is a cell surface receptor which elicits an immediate response to a wide repertoire of bacteria and viruses. Its response is usually thought to be proinflammatory rather than an antiviral.
Tatiana Gianni +1 more
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Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression.
PLoS ONE, 2021 Neuroendocrine prostate cancer (NEPrCa) arises de novo or after accumulation of genomic alterations in pre-existing adenocarcinoma tumors in response to androgen deprivation therapies.
Fabio Quaglia +11 more
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