Results 21 to 30 of about 35,992 (209)

Role of Integrin αvβ3 in Doxycycline-Induced Anti-Proliferation in Breast Cancer Cells

Frontiers in Cell and Developmental Biology, 2022
Doxycycline, an antibiotic, displays the inhibition of different signal transduction pathways, such as anti-inflammation and anti-proliferation, in different types of cancers.
Yi-Fong Chen, Yi-Fong Chen, Yung-Ning Yang, Yung-Ning Yang, Hung-Ru Chu, Hung-Ru Chu, Tung-Yung Huang, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Han-Yu Chen, Zi-Lin Li, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis, Paul J. Davis   +23 more
doaj   +1 more source

Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. [PDF]

, 2016
The αvβ3 integrin is known to be highly upregulated during cancer progression and promotes a migratory and metastatic phenotype in many types of tumors.
Fedele, Carmine, Keen, James H., Languino, Lucia R., Lu, Huimin, Nevalainen, Marja T., Singh, Amrita   +5 more
core   +2 more sources

Non-invasively differentiating extent of liver fibrosis by visualizing hepatic integrin αvβ3 expression with an MRI modality in mice

Biomaterials, 2016
To explore the potential of a dendrimer nanoprobe labeled with cyclic arginine-glycine-aspartic acid pentapeptide (cRGDyK) as a magnetic resonance imaging (MRI) tracer to non-invasively differentiate the extent of liver fibrosis.Synthetic dendrimer nanoprobes were labeled with cRGDyK (Den-RGD) to form a formulation of hepatic stellate cell (HSC ...
Li, Feng, Yan, Huihui, Wang, Jiyao, Li, Cong, Wu, Jian, Wu, Shengdi, Rao, Shengxiang, Gao, Xihui, Jin, Qu   +8 more
openaire   +4 more sources

Binding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status [PDF]

, 2017
Open Access via Springer Compact Agreement Acknowledgements We are very grateful to Prof. Calderwood (Yale University, USA) for providing the THD DNA construct, Dr.
Andriu, Alexandra, Crockett, Julie, Dall'Angelo, Sergio, Fleming, Ian N, Piras, Monica, Zanda, Matteo   +5 more
core   +1 more source

Disintegrin targeting of an αvβ3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro. [PDF]

, 2016
The in vitro efficacy of the disintegrin echistatin was tested on a high-metastatic variant of 143B human osteosarcoma, 143B-LM4, which over-expresses αvβ3 integrin. Echistatin is an RGD cyclic peptide and an antagonist of αvβ3 integrin.
Bouvet, Michael, Hoffman, Robert M, Kanaya, Fuminori, Kimura, Hiroaki, Kiyuna, Tasuku, Sugimoto, Naotoshi, Tome, Yasunori, Tsuchiya, Hiroyuki   +7 more
core   +4 more sources

Multimodality tumor imaging targeting integrin αvβ3

BioTechniques, 2005
The cell adhesion molecule integrin αvβ3 is an important player in the process of tumor angiogenesis and metastasis. Antibodies, peptides, peptidomimetics, and small molecule antagonists against integrin αvβ3 have been shown to induce endothelial ...
Weibo Cai, Sanjiv Sam Gambhir, Xiaoyuan Chen   +2 more
doaj   +1 more source

Involvement of integrin αvβ3 in thyroid hormone-induced dendritogenesis

Frontiers in Endocrinology, 2022
Activation and/or modulation of the membrane-associated receptors plays a critical role in brain development. Thyroid hormone (TH) acts on both nuclear receptors (thyroid hormone receptor, TR) and membrane-associated receptors, particularly integrin αvβ3
Winda Ariyani, Winda Ariyani, Wataru Miyazaki, Wataru Miyazaki, Izuki Amano, Noriyuki Koibuchi   +5 more
doaj   +1 more source

The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ανβ3 integrin in chick embryo and nude mouse models. [PDF]

, 2016
Echistatin, a cyclic RGD peptide, which is an antagonist of αvβ3 integrin (disintegrin), inhibited human osteosarcoma in the chick chorioallontoic membrane (CAM) model and tumor growth and pulmonary metastases in a nude mouse orthotopic model.
Bouvet, Michael, Hoffman, Robert M, Kanaya, Fuminori, Kimura, Hiroaki, Sugimoto, Naotoshi, Tome, Yasunori, Tsuchiya, Hiroyuki   +6 more
core   +4 more sources

The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis. [PDF]

, 2017
We recently found that integrin αvβ3 binds to fibroblast growth factor (FGF)-αvβ31 (FGF1), and that the integrin-binding defective FGF1 mutant (Arg-50 to glutamic acid, R50E) is defective in signalling and antagonistic to FGF1 signalling. R50E suppressed
Hamada, Yoshinosuke, Hatori, Nobuaki, Kawaguchi, Naomasa, Lam, Kit S, Matsuura, Nariaki, Mori, Seiji, Shih, Tsung-Chieh, Takada, Yoko K, Takada, Yoshikazu, Wu, Chun-Yi, Yamamoto, Hirofumi   +10 more
core   +2 more sources

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer [PDF]

, 2018
Therapeutic approaches aimed at curing prostate cancer are only partially successful given the occurrence of highly metastatic resistant phenotypes that frequently develop in response to therapies.
Altieri, Dario C., Bowler, Nicholas, Craig Hooper, D., Dutta, Anindita, Ertel, Adam, Fedele, Carmine, Forsberg, Flemming, Fortina, Paolo, Gabrilovich, Dmitry I., Harshyne, Larry A., Kean, Rhonda B., Kelly, William K., Kossenkov, Andrew V., Krishn, Shiv Ram, Kurtoglu, Senem, Languino, Lucia R., Liu, Qin, Lu, Huimin, Speicher, David W., Stanczak, Maria, Tang, Hsin-Yao, Wang, Kerith, Weinreb, Paul H., Yu, Lei   +23 more
core   +1 more source