Results 21 to 30 of about 25,536 (213)

Regulation of the integrin αVβ3- actin filaments axis in early osteogenesis of human fibroblasts under cyclic tensile stress

Stem Cell Research & Therapy, 2021
Background Integrins play a prominent role in osteogenic differentiation by transmitting both mechanical and chemical signals. Integrin expression is closely associated with tensile stress, which has a positive effect on osteogenic differentiation.
Yan Peng, Rongmei Qu, Yanting Feng, Xiaolan Huang, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Shutong Wu, Jingxing Dai, Jun Ouyang   +10 more
doaj   +1 more source

Role of Integrin αvβ3 in Doxycycline-Induced Anti-Proliferation in Breast Cancer Cells

Frontiers in Cell and Developmental Biology, 2022
Doxycycline, an antibiotic, displays the inhibition of different signal transduction pathways, such as anti-inflammation and anti-proliferation, in different types of cancers.
Yi-Fong Chen, Yi-Fong Chen, Yung-Ning Yang, Yung-Ning Yang, Hung-Ru Chu, Hung-Ru Chu, Tung-Yung Huang, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Han-Yu Chen, Zi-Lin Li, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis, Paul J. Davis   +23 more
doaj   +1 more source

Integrin-mediated cell-matrix interaction in physiological and pathological blood vessel formation [PDF]

, 2011
Physiological as well as pathological blood vessel formation are fundamentally dependent on cell-matrix interaction. Integrins, a family of major cell adhesion receptors, play a pivotal role in development, maintenance, and remodeling of the vasculature.
Stephan Niland, Eble, Johannes A., Niland, Stephan, Johannes A. Eble   +3 more
core   +1 more source

Induction of ligand promiscuity of αVβ3 integrin by mechanical force [PDF]

, 2020
αVβ3 integrin can bind to multiple extracellular matrix proteins, including vitronectin (Vn) and fibronectin (Fn), which are often presented to cells in culture as homogenous substrates.
Hytönen, Vesa P, Heiser, Lia, Krübel, Sarah, Franz, Clemens M., Wehrle-Haller, Bernhard, Bastmeyer, Martin, Franz, Clemens M, Mykuliak, Vasyl V., Ripamonti, Marta, Mykuliak, Vasyl V, Bachmann, Michael, Hytönen, Vesa P., Weißenbruch, Kai, Schäfer, Markus   +13 more
core   +1 more source

Non-invasively differentiating extent of liver fibrosis by visualizing hepatic integrin αvβ3 expression with an MRI modality in mice

Biomaterials, 2016
To explore the potential of a dendrimer nanoprobe labeled with cyclic arginine-glycine-aspartic acid pentapeptide (cRGDyK) as a magnetic resonance imaging (MRI) tracer to non-invasively differentiate the extent of liver fibrosis.Synthetic dendrimer nanoprobes were labeled with cRGDyK (Den-RGD) to form a formulation of hepatic stellate cell (HSC ...
Li, Feng, Yan, Huihui, Wang, Jiyao, Li, Cong, Wu, Jian, Wu, Shengdi, Rao, Shengxiang, Gao, Xihui, Jin, Qu   +8 more
openaire   +4 more sources

Integrin αvβ3 mediated adhesion to BM-ECM. [PDF]

, 2012
Expression of αvβ3 integrin on LNCaP cells mediates adhesion to bone marrow-derived extracellular matrix (BM-ECM). (A) Cell surface expression of αvβ3 integrin as measured by flow cytometry. (B) Anti-αvβ3 integrin antibody reduced cell adhesion to BM-ECM.
Carsten Werner (145899), Marina Prewitz (145892), Reynald M. Lescarbeau (145881), F. Philipp Seib (145886), David L. Kaplan (131325)   +4 more
core   +1 more source

An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA [PDF]

, 2012
Conradi J, Tegtmeyer N, Wozna M, et al. An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA. Frontiers in Cellular and Infection Microbiology.
Backert, Steffen, Tegtmeyer, Nicole, Timothy L Cover, Steffen Backert, Gagell, Corinna, Marta eWoźna, Marco eWissbrock, Cover, Timothy L., Sewald, Norbert ; https://orcid.org/, Michalek, Carmela, Frank, Ronald, Ronald eFrank, Norbert eSewald, Jens eConradi, Nicole Tegtmeyer, Carmela Michalek, Corinna eGagell, Jens Conradi, Steffen eBackert, Norbert Sewald, Carmela eMichalek, Marco Wissbrock, Wißbrock, Marco, Timothy L. Cover, Wozna, Marta, Marta Woźna, Corinna Gagell, Ronald Frank, Conradi, Jens, Nicole eTegtmeyer   +29 more
core   +2 more sources

Involvement of integrin αvβ3 in thyroid hormone-induced dendritogenesis

Frontiers in Endocrinology, 2022
Activation and/or modulation of the membrane-associated receptors plays a critical role in brain development. Thyroid hormone (TH) acts on both nuclear receptors (thyroid hormone receptor, TR) and membrane-associated receptors, particularly integrin αvβ3
Winda Ariyani, Winda Ariyani, Wataru Miyazaki, Wataru Miyazaki, Izuki Amano, Noriyuki Koibuchi   +5 more
doaj   +1 more source

αvβ3 integrin expression increases elasticity in human melanoma cells [PDF]

, 2020
International audienceLiving cells interact with the extracellular matrix (ECM) transducing biochemical signals into mechanical cues and vice versa. Thanks to this mechano-transduction process, cells modify their internal organization and upregulate ...
Rico, Felix, Lacaria, Leda, Lange, Janina, R, Goldmann, Wolfgang, H, Alonso, José Luis   +4 more
core   +3 more sources

The type I collagen induction of MT1-MMP-mediated MMP-2 activation is repressed by αVβ3 integrin in human breast cancer cells [PDF]

, 2007
The influence of αVβ3 integrin on MT1-MMP functionality was studied in human breast cancer cells of differing β3 integrin status. Overexpression of β3 integrin caused increased cell surface expression of αV integrin and increased cellular adhesion to ...
Thompson, Erik W., Borrirukwanit, Kulrut, Lafleur, Marc A., Tony Blick, Fridman, Rafael, Joseph J. Pereira, Mercuri, Francesca A., Price, John T., Francesca A. Mercuri, Blick, Tony, Vijittra Leardkamonkarn, Erik W. Thompson, Rafael Fridman, Kulrut Borrirukwanit, Pereira, Joseph J., Leardkamonkarn, Vijittra, John T. Price, Marc A. Lafleur   +17 more
core   +1 more source