Results 31 to 40 of about 25,536 (213)

Integrin αvβ3 mediates upregulation of epidermal growth-factor receptor expression and activity in human ovarian cancer cells [PDF]

, 2008
Upon overexpression of integrin αvβ3 and its engagement by vitronectin, we previously showed enhanced adhesion, proliferation, and motility of human ovarian cancer cells.
Lössner, Daniela, Abou-Ajram, Claudia, Benge, Anke, Reuning, Ute   +3 more
core   +1 more source

The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.

PLoS ONE, 2014
The chemokine domain of fractalkine (FKN-CD) binds to the classical RGD-binding site of αvβ3 and that the resulting ternary complex formation (integrin-FKN-CX3CR1) is critical for CX3CR1 signaling and FKN-induced integrin activation.
Masaaki Fujita, Yoko K Takada, Yoshikazu Takada   +2 more
doaj   +1 more source

Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure

Reproductive Biology and Endocrinology, 2021
Objective The aim of this study is to investigate the effect of irisin on leukemia inhibitory factor (LIF) and integrin αvβ3 in implantation failure uterus.
Li Zhou, Chenggang Li, Xiangshu Liu, Tao Zhang   +3 more
doaj   +1 more source

Expression of surface integrin-αvβ3 in U87MG cells with the treatment of 10 nM PTX. [PDF]

, 2013
(A) Cytometric analysis of the expression of integrin-αvβ3 was determined by specific integrin-αvβ3 antibody staining. The expression of integrin-αvβ3 in U87MG cells treated with 10 nM PTX for 12 hrs was higher than control group.
Jem-Mau Lo (321748), Hsueh-Fen Juan (63705), Ming-Wei Chang (321745), Chun-Yu Chuang (321752), Hsin-Yi Chang (103545)   +4 more
core   +1 more source

Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery

Angewandte Chemie, EarlyView.
Non‐orthosteric, low‐affinity ligands for integrin αVβ3, identified by fragment screening, achieve superselective nanoparticle targeting (ακ ≈ 3) of αVβ3‐overexpressing endothelial cells. Unlike traditional arginine–glycine–aspartate decorated particles, these fragment‐functionalized LNPs discriminate cells by receptor density and deliver mRNA to ...
Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou, Christoph Rademacher   +7 more
wiley   +2 more sources

Application of Force to a Syndecan-4 Containing Complex With Thy-1–αVβ3 Integrin Accelerates Neurite Retraction

Frontiers in Molecular Biosciences, 2020
Inflammation contributes to the genesis and progression of chronic diseases, such as cancer and neurodegeneration. Upregulation of integrins in astrocytes during inflammation induces neurite retraction by binding to the neuronal protein Thy-1, also known
Francesca Burgos-Bravo, Francesca Burgos-Bravo, Francesca Burgos-Bravo, Samuel Martínez-Meza, Samuel Martínez-Meza, Andrew F. G. Quest, Andrew F. G. Quest, Christian A. M. Wilson, Lisette Leyton, Lisette Leyton   +9 more
doaj   +1 more source

Force regulated conformational change of integrin αVβ3 [PDF]

, 2016
Integrins mediate cell adhesion to extracellular matrix and transduce signals bidirectionally across the membrane. Integrin αVβ3 has been shown to play an essential role in tumor metastasis, angiogenesis, hemostasis and phagocytosis.
Schwartz, Martin
core   +4 more sources

Optimization of RGD-Containing Cyclic Peptides against αvβ3 Integrin [PDF]

, 2016
We have previously reported the use of one-bead-one-compound (OBOC) combinatorial technology to develop a disulfide cyclic, Arg-Gly-Asp-containing octapeptide LXW7 (cGRGDdvc), that targets αvβ3 integrin with high affinity and specificity.
Ames, James B, Lam, Kit S, Ames, James B., Zhang, Yonghong, Takada, Yoshikazu, Meza, Leah, Lam, Kit S., Wang, Yan, Xiao, Wenwu, Tseng, Harry   +9 more
core   +1 more source

Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. [PDF]

PLoS ONE, 2015
Epithelial-to-mesenchymal transition (EMT) plays a critical role in cancer metastasis, and is regulated by growth factors such as transforming growth factor β (TGF-β) and fibroblast growth factors (FGF) secreted from the stromal and tumor cells. However,
Seiji Mori, Moe Kodaira, Ayano Ito, Mika Okazaki, Naomasa Kawaguchi, Yoshinosuke Hamada, Yoshikazu Takada, Nariaki Matsuura   +7 more
doaj   +1 more source

Interaction of integrin αvβ3 and fibronectin under fluid shear forces: implications for tumor cell adhesion and migration

Frontiers in Cell and Developmental Biology
The interaction between integrin αvβ3 and fibronectin enables tumor cell adherence to endothelial layers under diverse hydrodynamic blood flow conditions, particularly in low shear stress regions.
Paimin Zhuo, Quhuan Li, Bishan Yang, Bishan Yang, Na Li, Zhiqing Luo, Fengxia Zhang   +6 more
doaj   +1 more source