Results 51 to 60 of about 25,536 (213)
UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression
Advanced Science, EarlyView.UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma +14 more
wiley +1 more source
Scientific Reports, 2022 Gadolinium (Gd)-based contrast agents (GBCAs) are chemicals injected intravenously during magnetic resonance imaging to enhance the diagnostic yield. Repeated use of GBCAs causes their deposition in the brain.
Winda Ariyani +3 more
doaj +1 more source
Cancer Treatment and Research Communications, 2021 Integrins are a family of heterodimeric plasma membrane glycoproteins, which regulate tumor growth, angiogenesis, migration, and metastasis. Integrin αvβ3 has been recognized as a putative target for the treatment of several cancers.
Kavitha Godugu +3 more
doaj +1 more source
Glioblastomas Require Integrin αvβ3/PAK4 Signaling to Escape Senescence [PDF]
, 2015 Integrin αvβ3 has been implicated as a driver of aggressive and metastatic disease, and is upregulated during glioblastoma progression. Here, we demonstrate that integrin αvβ3 allows glioblastoma cells to counteract senescence through a novel tissue ...
Elliott, Kathryn C +5 more
core +1 more source
Integrin-targeted quantitative optoacoustic imaging with MRI correlation for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma. [PDF]
PLoS ONE, 2018 PURPOSE:To investigate αvβ3-integrin-targeted optoacoustic imaging and MRI for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma. MATERIALS AND METHODS:Human BRAF V600E-positive melanoma xenograft (A375)-bearing Balb/
Philipp M Kazmierczak +11 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi +6 more
wiley +1 more source
Cell Communication and Signaling, 2023 Background Integrins are closely related to mechanical conduction and play a crucial role in the osteogenesis of human mesenchymal stem cells. Here we wondered whether tensile stress could influence cell differentiation through integrin αVβ3.
Yan Peng +12 more
doaj +1 more source
Modulation of integrin activity for diagnostic and therapeutic applications [PDF]
, 2010 SUMMARY Over the past decade, the scientific research spent many efforts to develop therapeutic and diagnostic systems able to contact selectively the target cells and to minimize their diffusion in healthy organs.
De Simone, Mariarosaria
core
Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery
ChemistryOpen, 2019 RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable linkers.
Adina Borbély +13 more
doaj +1 more source
αVβ3 Integrin regulates astrocyte reactivity [PDF]
, 2017 Indexación: ScopusBackground: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging αVβ3 Integrin and Syndecan-4.
Alvarez, Alvaro +13 more
core