Results 61 to 70 of about 25,536 (213)
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
Expression of integrin αvβ3 in pig, dog and cattle [PDF]
, 2011 The αvβ3 integrin, also known as vitronectin receptor, is an adhesive glycoprotein that promotes angiogenesis i n the embryo and tumors such as melanoma. Integrin αvβ3 is one of the receptors for adenovirus and hantavirus.
Kaur, A., Singh, B., Rawlings, N.
core +1 more source
Integrin αvβ3 Signaling in Tumor-Induced Bone Disease [PDF]
, 2017 Tumor-induced bone disease is common among patients with advanced solid cancers, especially those with breast, prostate, and lung malignancies. The tendency of these cancers to metastasize to bone and induce bone destruction is, in part, due to ...
Kristin Kwakwa, Julie Sterling
core +1 more source
Sca-1 is involved in the adhesion of myosphere cells to αVβ3 integrin
Biology Open, 2012 Summary A myosphere cell is a unique type of muscle stem cell that is able to maintain its pre-myogenic state in culture over time. These cells are propagated in culture as free-floating, non-adherent spheres.
Ashley Penvose, Karen A. Westerman
doaj +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Increased renal integrin αvβ3 expression in anti-GBM disease. [PDF]
, 2013 (a–c) IHC staining of mouse kidney sections with an anti-integrin αvβ3 antibody (1:500 dilution). (a) Normal control kidney; (b) nephritic kidney subjected to anti-GBM disease; (c) Semi-quantitative analysis of integrin αvβ3 expression (N = 6 for each ...
Xin J. Zhou (305431) +6 more
core +1 more source
BMEMat, EarlyView.A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song +10 more
wiley +1 more source
Journal of Translational Medicine, 2017 Background Radiolabeled RGD peptides detect αvβ3 integrin expression associated with angiogenesis and extracellular matrix remodeling after myocardial infarction. We studied whether cardiac positron emission tomography (PET) with [68Ga]NODAGA-RGD detects
Maria Grönman +15 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
Ligand binding promiscuity of αVβ3 integrin is enlarged in response to mechanical force [PDF]
, 2017 αVβ3 integrin recognizes multiple extracellular matrix proteins, including vitronectin (Vn) and fibronectin (Fn). However, cell experiments are frequently performed on homogenously coated substrates with only one integrin ligand present.
Vasyl V. Mykuliak +10 more
core +1 more source