Results 61 to 70 of about 35,992 (209)

Conjugates of Cryptophycin and RGD or isoDGR Peptidomimetics for Targeted Drug Delivery

ChemistryOpen, 2019
RGD‐cryptophycin and isoDGR‐cryptophycin conjugates were synthetized by combining peptidomimetic integrin ligands and cryptophycin, a highly potent tubulin‐binding antimitotic agent across lysosomally cleavable Val‐Ala or uncleavable linkers.
Adina Borbély, Dr. Eduard Figueras, Ana Martins, Dr. Lizeth Bodero, Dr. André Raposo Moreira Dias, Dr. Paula López Rivas, Dr. Arianna Pina, Dr. Daniela Arosio, Dr. Paola Gallinari, Dr. Marcel Frese, Dr. Christian Steinkühler, Prof. Dr. Cesare Gennari, Prof. Dr. Umberto Piarulli, Prof. Dr. Norbert Sewald   +13 more
doaj   +1 more source

Kallikrein gene-modified EPCs induce angiogenesis in rats with ischemic hindlimb and correlate with integrin αvβ3 expression. [PDF]

PLoS ONE, 2013
BACKGROUND: Human tissue kallikrein (hTK) plays an essential role in the physiological and pathological mechanisms of blood vessels. This study aimed to determine whether angiogenesis induced by endothelial progenitor cells (EPCs) transduced with the ...
Shen Shen Fu, Fu Ji Li, Yuan Yuan Wang, An Bei You, Yi Liang Qie, Xiao Meng, Jian Rui Li, Bao Chuan Li, Yun Zhang, Qing Da Li   +9 more
doaj   +1 more source

Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome. [PDF]

, 2016
Integrins αvβ3 and αvβ5 regulate angiogenesis and invasiveness in cancer, potentially by modulating activation of the transforming growth factor (TGF)-β pathway.
Bady, P., Goodman, S.L., Gorlia, T., Hegi, M.E., Hicking, C., Hong, Y.K., Leske, H., Moch, H., Nabors, L.B., Perry, J., Picard, M., Roth, P., Rushing, E., Straub, J., Stupp, R., Weller, M., Wick, W.   +16 more
core   +2 more sources

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Integrin-targeted quantitative optoacoustic imaging with MRI correlation for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma. [PDF]

PLoS ONE, 2018
PURPOSE:To investigate αvβ3-integrin-targeted optoacoustic imaging and MRI for monitoring a BRAF/MEK inhibitor combination therapy in a murine model of human melanoma. MATERIALS AND METHODS:Human BRAF V600E-positive melanoma xenograft (A375)-bearing Balb/
Philipp M Kazmierczak, Neal C Burton, Georg Keinrath, Heidrun Hirner-Eppeneder, Moritz J Schneider, Ralf S Eschbach, Maurice Heimer, Olga Solyanik, Andrei Todica, Maximilian F Reiser, Jens Ricke, Clemens C Cyran   +11 more
doaj   +1 more source

Cellular trafficking of Sn-2 phosphatidylcholine prodrugs studied with fluorescence lifetime imaging and super-resolution microscopy [PDF]

, 2018
While ...
Achilefu, Samuel, Cui, Grace, Lanza, Gregory M, Lew, Matthew D, Lu, Jin, Maji, Dolonchampa, Pan, Dipanjan, Sarder, Pinaki, Schmieder, Anne H, Yang, Xiaoxia   +9 more
core   +1 more source

Integrins as therapeutic targets: lessons and opportunities. [PDF]

, 2010
The integrins are a large family of cell adhesion molecules that are essential for the regulation of cell growth and function. The identification of key roles for integrins in a diverse range of diseases, including cancer, infection, thrombosis and ...
A Artoni, A Carter, A Etzioni, A Kato, A Loughman, A McDowall, A Qu, A Robinson, A Salas, AD Ricart, AJ Ablooglu, AL Muranyi, AM Weljie, AR Reynolds, AW Partridge, B Furie, BG Feagan, BG Petrich, BP Feuston, BS Coller, C Delbaldo, C Kummer, C Kummer, C Leonardi, C Lu, C Ng, C Rosano, C Warnke, C Xie, CH Polman, CJ Avraamides, CL Leonardi, CL Tofteng, CS Tan, CS Yoon, D Chua, D Cox, D Cox, D Larkin, D Potin, DA Calderwood, DA Calderwood, DA Chudakova, DA Reardon, Dermot Cox, DJ White, DP Chew, DR Phillips, DS Dodd, DS Harburger, E Bernard, E Havrdova, E Manevich, E Ruoslahti, EO Major, FC Gushiken, FE Fleming, G Weitz-Schmidt, GA Caputo, GM D'Abaco, GPA Rice, H Jin, H Yin, H Zhang, H-J Lee, I Ahrens, J Bennett, J Kallen, J Kalra, J Lim, J Morova, J Takagi, J Takagi, J Tamkun, JA Askari, JA Nemeth, JC O'Shea, JE Frampton, JE Smith-Garvin, JP Ortonne, JP Xiong, JP Xiong, JR Fitzgerald, JR Fitzgerald, JR Morgan, JW Tilley, K Aylward, K Peter, K Peter, K Welzenbach, K Yao, K Yuki, KB Gordon, KB Reddy, KL Graham, KL Graham, KL Schornberg, KL Wegener, KR Legate, KV Vijayan, L Dubertret, L Steinman, L Xudong, LM Kenny, M Brennan, M Champe, M Egbertson, M Kim, M Lebwohl, M Martchenko, M Moser, M Raab, M Rosenthal, M Shimaoka, M Shimaoka, M Shimaoka, M Shimaoka, MA Arnaout, Marian Brennan, MC Joseph, ME Cianfrocca, MG Murphy, MN Younes, MP Bonaca, MP Brennan, MP Crump, N Laurens, Niamh Moran, NS Nicholson, O Vinogradova, O Vinogradova, P Hersey, P Koistinen, PA Calabresi, PC McDonald, PE Hughes, PL Stewart, QY Liu, R Anders, R Axelsson, R Blue, R Curtin, R Evans, R Gonzalez-Amaro, R Pytela, R Silva, R Stragies, R Stupp, RA Rudick, RH Aster, RJ Davenport, RJ Davenport, RM Scarborough, RO Hynes, RP Dassanayake, S Honda, S Honda, S Kim, S Kim, S Li, S Liu, S Moschos, S O'Neill, S Wattanasin, SH Watterson, SJ Hyduk, SJ Monkley, SJ Moschos, SJ Shattil, SM Keating, SM Weis, SR Barthel, SR Targan, T Dileepan, T Kwok, T Weller, T Xiao, TA Kelly, TA Yednock, TC Sroka, TE O'Toole, TE Spencer, TJ MacDonald, TM Brophy, TR Gadek, UP Naik, VA Umans, W Humphrey, W Jia, W Neidhart, W Wang, W Yang, X Sewald, Y Aga, Y Funahashi, Y Gong, Y Li, Y Wang, YF Li, YQ Ma   +199 more
core   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Structural basis for pure antagonism of integrin αVβ3 by a high affinity form of fibronectin [PDF]

, 2014
Integrins are important therapeutic targets. However, current RGD-based anti-integrin drugs are also partial agonists, inducing conformational changes that trigger potentially fatal immune reactions and paradoxical cell adhesion.
Adair, Brian D., Alonso, José Luis, Arnaout, M. Amin, Goodman, Simon L., Rui, Xianliang, Van Agthoven, Johannes F., Xiong, Jian-Ping   +6 more
core   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source